2022
Thermal effects on neurons during stimulation of the brain
Kim T, Kadji H, Whalen A, Ashourvan A, Freeman E, Fried S, Tadigadapa S, Schiff S. Thermal effects on neurons during stimulation of the brain. Journal Of Neural Engineering 2022, 19: 056029. PMID: 36126646, PMCID: PMC9855718, DOI: 10.1088/1741-2552/ac9339.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBiophysicsBrainElectric ConductivityElectric StimulationElectrodesMammalsNeuronsConceptsThermal effectsJoule heatingMagnetic coilsRate dependencyElectrical interactionsSmall thermal effectsTemperature changesDissipation of energyNumerical modelingRange of frequenciesThermal energyMagnetic fieldDC drivingMagnetic inductionElectrical currentStatic magnetic fieldSmall temperature increaseTemperature increaseAccurate modulationCoilEnergy depositionHeatingConductorsTransient effectsElectrode
2018
Control of Spreading Depression with Electrical Fields
Whalen A, Xiao Y, Kadji H, Dahlem M, Gluckman B, Schiff S. Control of Spreading Depression with Electrical Fields. Scientific Reports 2018, 8: 8769. PMID: 29884896, PMCID: PMC5993812, DOI: 10.1038/s41598-018-26986-1.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainCerebral CortexCortical Spreading DepressionElectric StimulationMaleNeuronsOptical ImagingPotassiumRats, Sprague-DawleyConceptsElectric fieldField polarityDC electric fieldElectric field polarityElectrical controlOptical imagingPropagation pathIntrinsic optical imagingOpposite signDepression propagatesElectrical fieldField terminationElectro-chemical gradientPropagation velocityPropagatesFieldTraumatic brain injuryPropagationConfinementMore superficial layersDepression propagationBrain injurySynaptic transmissionBrain slicesWaves
2012
Modulation of hippocampal rhythms by subthreshold electric fields and network topology
Berzhanskaya J, Chernyy N, Gluckman B, Schiff S, Ascoli G. Modulation of hippocampal rhythms by subthreshold electric fields and network topology. Journal Of Computational Neuroscience 2012, 34: 369-389. PMID: 23053863, PMCID: PMC3549326, DOI: 10.1007/s10827-012-0426-4.Peer-Reviewed Original ResearchConceptsPyramidal cellsGamma rhythmsHippocampal rhythmsSubthreshold electric fieldsSpecific synaptic connectivityExact cellular mechanismsExcitatory contactsSynaptic circuitryBasket cellsLines of resultsArea CA1Inhibitory connectivityInterneuron typesSynaptic connectivityInterneuron classesHippocampal functionNeuron typesNeuronal morphologyTheta/gamma ratioCognitive functionTheta frequencyCellular mechanismsNeural activityElectrophysiological dataNovel role
2009
Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model
Sunderam S, Chernyy N, Peixoto N, Mason J, Weinstein S, Schiff S, Gluckman B. Seizure entrainment with polarizing low-frequency electric fields in a chronic animal epilepsy model. Journal Of Neural Engineering 2009, 6: 046009. PMID: 19602730, PMCID: PMC3057918, DOI: 10.1088/1741-2560/6/4/046009.Peer-Reviewed Original ResearchConceptsField postsynaptic potentialsAnimal epilepsy modelsNeural activitySimultaneous recordingSpontaneous seizuresHippocampal epilepsyVentral hippocampusEpilepsy modelLocal field potentialsPostsynaptic potentialsNeuronal excitabilityNeuronal activityModulatory effectsAnimal modelsSeizuresStatistical significanceStimulationField potentialsMultiple presentationsAnimalsCharacteristic patternEpilepsyHippocampusRecordingsExcitabilityTime dependence of stimulation/recording-artifact transfer function estimates for neural interface systems
Chernyy N, Schiff S, Gluckman B. Time dependence of stimulation/recording-artifact transfer function estimates for neural interface systems. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2009, 2009: 1380-1383. PMID: 19964759, PMCID: PMC5502111, DOI: 10.1109/iembs.2009.5334297.Peer-Reviewed Original ResearchConceptsControl systemElectrode interface propertiesLow-frequency electric fieldNeural interface systemInterface propertiesControl outputElectric fieldElectrical potential variationsElectrical currentTransfer function magnitudeImpedance changesSystem stateMeasurement pointsInterface systemFunction magnitudeNeural control systemSimultaneous measurementTime dependencePotential variationPropertiesStimulus artifactTransfer function estimatesSystemFilterCurrent
2008
Multi-taper transfer function estimation for stimulation artifact removal from neural recordings
Chernyy N, Schiff S, Gluckman B. Multi-taper transfer function estimation for stimulation artifact removal from neural recordings. Annual International Conference Of The IEEE Engineering In Medicine And Biology Society (EMBC) 2008, 2008: 2772-2776. PMID: 19163280, PMCID: PMC3547985, DOI: 10.1109/iembs.2008.4649777.Peer-Reviewed Original Research
2005
A Model of the Effects of Applied Electric Fields on Neuronal Synchronization
Park E, Barreto E, Gluckman B, Schiff S, So P. A Model of the Effects of Applied Electric Fields on Neuronal Synchronization. Journal Of Computational Neuroscience 2005, 19: 53-70. PMID: 16133825, PMCID: PMC1752229, DOI: 10.1007/s10827-005-0214-5.Peer-Reviewed Original ResearchControl of Traveling Waves in the Mammalian Cortex
Richardson K, Schiff S, Gluckman B. Control of Traveling Waves in the Mammalian Cortex. Physical Review Letters 2005, 94: 028103. PMID: 15698234, PMCID: PMC1513188, DOI: 10.1103/physrevlett.94.028103.Peer-Reviewed Original Research
2003
Sensitivity of Neurons to Weak Electric Fields
Francis J, Gluckman B, Schiff S. Sensitivity of Neurons to Weak Electric Fields. Journal Of Neuroscience 2003, 23: 7255-7261. PMID: 12917358, PMCID: PMC6740448, DOI: 10.1523/jneurosci.23-19-07255.2003.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsCells, CulturedElectric StimulationElectricityNerve NetNeuronsPyramidal CellsRatsRats, Sprague-DawleyIn Vivo Modulation of Hippocampal Epileptiform Activity with Radial Electric Fields
Richardson K, Gluckman B, Weinstein S, Glosch C, Moon J, Gwinn R, Gale K, Schiff S. In Vivo Modulation of Hippocampal Epileptiform Activity with Radial Electric Fields. Epilepsia 2003, 44: 768-777. PMID: 12790889, DOI: 10.1046/j.1528-1157.2003.35402.x.Peer-Reviewed Original ResearchMeSH KeywordsAmplifiers, ElectronicAnimalsDisease Models, AnimalElectric StimulationElectric Stimulation TherapyElectrodes, ImplantedElectronics, MedicalEpilepsyHippocampusHumansKainic AcidKindling, NeurologicMaleMembrane PotentialsMicroelectrodesRatsRats, Sprague-DawleySeizuresStereotaxic TechniquesConceptsElectric field modulationRadial electric fieldElectric fieldElectric field controlField modulationMicroelectrode pairsCharge deliveryControl systemElectrode geometryField controlSeizure onset detectionElectrodeElectric field stimulationElectronicsStimulation electrodesFieldFirst resultsNovel approachExperiments
1995
Periodic pacing an in vitro epileptic focus
Jerger K, Schiff S. Periodic pacing an in vitro epileptic focus. Journal Of Neurophysiology 1995, 73: 876-879. PMID: 7760143, DOI: 10.1152/jn.1995.73.2.876.Peer-Reviewed Original Research
1994
An experimental study of reflex variability in selective dorsal rhizotomy.
Rivera A, Burke T, Schiff S, Weiss I. An experimental study of reflex variability in selective dorsal rhizotomy. Journal Of Neurosurgery 1994, 81: 885-94. PMID: 7965119, DOI: 10.3171/jns.1994.81.6.0885.Peer-Reviewed Original ResearchFluctuations of excitability in the monosynaptic reflex pathway to lumbar motoneurons in the cat
Gossard J, Floeter M, Kawai Y, Burke R, Chang T, Schiff S. Fluctuations of excitability in the monosynaptic reflex pathway to lumbar motoneurons in the cat. Journal Of Neurophysiology 1994, 72: 1227-1239. PMID: 7807207, DOI: 10.1152/jn.1994.72.3.1227.Peer-Reviewed Original ResearchControlling chaos in the brain
Schiff S, Jerger K, Duong D, Chang T, Spano M, Ditto W. Controlling chaos in the brain. Nature 1994, 370: 615-620. PMID: 8065447, DOI: 10.1038/370615a0.Peer-Reviewed Original ResearchDiscriminating deterministic versus stochastic dynamics in neuronal activity
Schiff S, Sauer T, Chang T. Discriminating deterministic versus stochastic dynamics in neuronal activity. Integrative Psychological And Behavioral Science 1994, 29: 246-261. PMID: 7811645, DOI: 10.1007/bf02691329.Peer-Reviewed Original Research
1993
Reflex variability in selective dorsal rhizotomy.
Weiss I, Schiff S. Reflex variability in selective dorsal rhizotomy. Journal Of Neurosurgery 1993, 79: 346-53. PMID: 8360730, DOI: 10.3171/jns.1993.79.3.0346.Peer-Reviewed Original Research