2017
A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection
Ssentongo P, Robuccio A, Thuku G, Sim D, Nabi A, Bahari F, Shanmugasundaram B, Billard M, Geronimo A, Short K, Drew P, Baccon J, Weinstein S, Gilliam F, Stoute J, Chinchilli V, Read A, Gluckman B, Schiff S. A Murine Model to Study Epilepsy and SUDEP Induced by Malaria Infection. Scientific Reports 2017, 7: 43652. PMID: 28272506, PMCID: PMC5341121, DOI: 10.1038/srep43652.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsDeath, SuddenDisease Models, AnimalElectroencephalographyEpilepsyMalaria, CerebralMaleMicePlasmodium bergheiSurvival AnalysisConceptsCerebral malariaAnimal modelsStrain combinationsPrevention of epilepsySuch animal modelsSubsequent epilepsyNeurological sequelaeAdjunctive therapyPathophysiological mechanismsMalaria infectionUnexpected deathMurine modelEpilepsyPreclinical researchSUDEPMalariaGenetic backgroundMultiple miceEpileptogenesisSequelaeTherapyInfectionMiceSurvivorsPrevention
2011
Five-year survival and outcome of treatment for postinfectious hydrocephalus in Ugandan infants.
Warf B, Dagi A, Kaaya B, Schiff S. Five-year survival and outcome of treatment for postinfectious hydrocephalus in Ugandan infants. Journal Of Neurosurgery Pediatrics 2011, 8: 502-8. PMID: 22044377, DOI: 10.3171/2011.8.peds11221.Peer-Reviewed Original ResearchConceptsPostinfectious hydrocephalusFive-year survivalShunt placementPrimary brain injuryWorse functional outcomeKaplan-Meier methodLong-term outcomesLog-rank testOutcome of treatmentEndoscopic third ventriculostomyTreatment selection biasPublic health measuresOne-thirdUgandan infantsWorst sequelaeOperative mortalityNeonatal infectionFunctional outcomeThird ventriculostomyBrain injuryPrimary treatmentCommon causeInfant hydrocephalusSurvival advantageOriginal infection