2012
Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events
Žiburkus J, Cressman J, Schiff S. Seizures as imbalanced up states: excitatory and inhibitory conductances during seizure-like events. Journal Of Neurophysiology 2012, 109: 1296-1306. PMID: 23221405, PMCID: PMC3602838, DOI: 10.1152/jn.00232.2012.Peer-Reviewed Original ResearchConceptsSeizure-like eventsO-LM cellsPyramidal cellsInhibitory conductanceOriens-lacunosum moleculare (O-LM) interneuronsNeuronal network hyperexcitabilityExcitability of interneuronsCA1 pyramidal cellsInhibitory synaptic conductancesNetwork hyperexcitabilityRecurrent seizuresMoleculare interneuronsSeizure initiationNeural network activityRat hippocampusExtracellular magnesiumSynaptic barragesFiring patternsSeizuresExcitatoryCellular subtypesSynaptic conductancesInterneuronsNetwork activityCell types
2008
30 Towards a Dynamics of Seizure Mechanics
Schiff S, Cressman J, Barreto E, Žiburkus J. 30 Towards a Dynamics of Seizure Mechanics. 2008, 496-xviii. DOI: 10.1016/b978-012373649-9.50033-8.Peer-Reviewed Original ResearchDepolarization blockRelevant neuronal subtypesExcitatory principal cellsHippocampal seizuresGap junction connectivityPyramidal cellsHuman epilepsyInhibitory interneuronsIntracellular recordingsSynaptic currentsNeuronal subtypesHuman seizuresSeizuresInterneuronsPrincipal cellsSeizure dynamicsTime courseSynchrony featuresNeuronal dynamicsCellsEpilepsy