2024
Paediatric hydrocephalus
Kahle K, Klinge P, Koschnitzky J, Kulkarni A, MacAulay N, Robinson S, Schiff S, Strahle J. Paediatric hydrocephalus. Nature Reviews Disease Primers 2024, 10: 35. PMID: 38755194, DOI: 10.1038/s41572-024-00519-9.Peer-Reviewed Original ResearchConceptsSymptoms of elevated intracranial pressureCerebrospinal fluidCentral nervous system infectionChoroid plexus cauterizationEndoscopic third ventriculostomyNervous system infectionNonsurgical treatment strategiesElevated intracranial pressureLong-term outcomesNeural tube defectsCSF-brain interfaceFetal hydrocephalusUtero treatmentAcquired hydrocephalusCSF secretionSurgical closureCSF shuntingHead circumferenceThird ventriculostomyCongenital hydrocephalusAssociated with blockageGene mutationsCerebral ventricleTreatment strategiesCSF pathways
2019
The Incidence of Postoperative Seizures Following Treatment of Postinfectious Hydrocephalus in Ugandan Infants: A Post Hoc Comparison of Endoscopic Treatment vs Shunt Placement in a Randomized Controlled Trial.
Punchak M, Mbabazi Kabachelor E, Ogwal M, Nalule E, Nalwoga J, Ssenyonga P, Mugamba J, Rattani A, Dewan M, Kulkarni A, Schiff S, Warf B. The Incidence of Postoperative Seizures Following Treatment of Postinfectious Hydrocephalus in Ugandan Infants: A Post Hoc Comparison of Endoscopic Treatment vs Shunt Placement in a Randomized Controlled Trial. Neurosurgery 2019, 85: e714-e721. PMID: 31086941, PMCID: PMC7534394, DOI: 10.1093/neuros/nyz122.Peer-Reviewed Original ResearchConceptsChoroid plexus cauterizationETV/CPCPostoperative seizure incidencePostinfectious hydrocephalusSeizure incidenceEndoscopic third ventriculostomyUgandan infantsShunt placementMantel-Haenszel hazard ratiosKaplan-Meier methodVentriculoperitoneal shunt placementPostoperative epilepsyPostoperative seizuresPreoperative symptomsEpilepsy incidenceFirst seizureHazard ratioControlled TrialsEndoscopic treatmentThird ventriculostomyTreatment modalitiesSeizure riskHead circumferenceRelative riskSeizure onset
2010
The dynamics of brain and cerebrospinal fluid growth in normal versus hydrocephalic mice.
Mandell J, Neuberger T, Drapaca C, Webb A, Schiff S. The dynamics of brain and cerebrospinal fluid growth in normal versus hydrocephalic mice. Journal Of Neurosurgery Pediatrics 2010, 6: 1-10. PMID: 20593980, DOI: 10.3171/2010.4.peds1014.Peer-Reviewed Original ResearchMeSH KeywordsAge FactorsAlgorithmsAnimalsAnimals, NewbornBrainCephalometryCerebral AqueductCerebral VentriclesDisease Models, AnimalFourier AnalysisFrontal LobeHydrocephalusImage Processing, Computer-AssistedImaging, Three-DimensionalIntracranial PressureLateral VentriclesMagnetic Resonance ImagingMathematical ComputingMiceMice, Inbred C57BLOccipital LobeOrgan SizeReference ValuesConceptsHydrocephalic miceBrain volumeClinical outcomesBrain growthVentricle volumeDynamics of brainCortical mantle thicknessPatterns of hydrocephalusOccipital horn ratioAccumulation of CSFTransmantle pressure gradientGrowth of brainVentricular ruptureParenchymal edemaVentricular sizeC57BL/6 miceTotal brainPercutaneous injectionAdjunct useHead circumferenceNormal miceCisterna magnaCSF volumeCognitive functionSerial quantification