2023
Increasing Spiritual Beliefs are Associated With Lower HIV Incidence Among Black Men Who Have Sex With Men: Results From HPTN 061 Longitudinal Study
Ransome Y, Taggart T, Huang A, Vermund S, Mayer K, Nunn A. Increasing Spiritual Beliefs are Associated With Lower HIV Incidence Among Black Men Who Have Sex With Men: Results From HPTN 061 Longitudinal Study. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 94: 196-202. PMID: 37850978, DOI: 10.1097/qai.0000000000003278.Peer-Reviewed Original ResearchConceptsHIV seroconversionHIV incidenceBehavioral HIV prevention interventionsLower HIV incidenceProportional hazards regressionHIV prevention interventionsBlack menSpiritual beliefsOne-unit increaseHazards regressionLongitudinal riskPrevention interventionsHIVBiomedical assessmentLower hazard rateLongitudinal studyMenMonthsSeroconversionLongitudinal analysisReligious service attendanceIncidenceBaselineBMSMHigher proportion
2022
Voluntary Medical Male Circumcision to Reduce HIV Acquisition and Transmission
Vermund S. Voluntary Medical Male Circumcision to Reduce HIV Acquisition and Transmission. Current HIV/AIDS Reports 2022, 19: 471-473. PMID: 36478080, PMCID: PMC10767716, DOI: 10.1007/s11904-022-00631-z.Peer-Reviewed Original ResearchMeSH KeywordsAfrica South of the SaharaCircumcision, MaleFemaleHIV InfectionsHumansIncidenceMalePrevalenceConceptsHIV acquisitionVoluntary medical male circumcisionHIV infection acquisitionVoluntary medical male circumcision (VMMC) programsMinor surgical interventionsMale circumcision programsHIV incidence ratesHigh HIV prevalenceMedical male circumcisionFirst clinical trialUninfected menHIV incidenceHIV prevalenceInfection acquisitionSaharan AfricaSurgical interventionCircumcision programsClinical trialsIncidence ratePreventive benefitsHIV riskCircumcision ratesRecent FindingsSinceMale circumcisionHealth section
2021
Human Immunodeficiency Virus Infection and Incident Heart Failure: A Meta-Analysis of Prospective Studies
Chen Y, Gao Y, Zhou Y, Li X, Wang H, Polonsky TS, Vermund SH, Qian HZ, Qian F. Human Immunodeficiency Virus Infection and Incident Heart Failure: A Meta-Analysis of Prospective Studies. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2021, 87: 741-749. PMID: 33492019, PMCID: PMC10768809, DOI: 10.1097/qai.0000000000002629.Peer-Reviewed Original ResearchConceptsIncident heart failureLow CD4 countHeart failureHIV infectionRandom-effects modelCD4 countSubgroup analysisRisk of HFHuman immunodeficiency virus (HIV) infectionLaird random-effects modelYoung adultsAvailable prospective evidenceImmunodeficiency virus infectionPooled relative riskFull-text assessmentWeb of ScienceFixed-effects modelProspective studyIncident casesProspective evidenceRelative riskVirus infectionFunnel plotMeta-AnalysisSimilar association
2020
Integrating and Interpreting Findings from the Latest Treatment as Prevention Trials
Brault MA, Spiegelman D, Abdool Karim SS, Vermund SH. Integrating and Interpreting Findings from the Latest Treatment as Prevention Trials. Current HIV/AIDS Reports 2020, 17: 249-258. PMID: 32297219, PMCID: PMC7260110, DOI: 10.1007/s11904-020-00492-4.Peer-Reviewed Original Research
2019
Treatment as Prevention: Concepts and Challenges for Reducing HIV Incidence
Brault MA, Spiegelman D, Hargreaves J, Nash D, Vermund SH. Treatment as Prevention: Concepts and Challenges for Reducing HIV Incidence. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2019, 82: s104-s112. PMID: 31658196, PMCID: PMC6820703, DOI: 10.1097/qai.0000000000002168.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHIV transmissionHIV plasma loadReducing HIV IncidenceHIV prevention trialsCommunity-level interventionsDeployable vaccineViral suppressionHIV testingHIV incidencePrevention trialsUninfected personsChronic conditionsHIV investmentsEarly treatmentTreat strategySexual partnersViral expressionTransmission riskHIVTrialsTreatmentInconsistent findingsPreventionSaharan AfricaPredicting the long-term impact of voluntary medical male circumcision on HIV incidence among men who have sex with men in Beijing, China
Zhang C, Webb GF, Lou J, Shepherd BE, Qian HZ, Liu Y, Vermund SH. Predicting the long-term impact of voluntary medical male circumcision on HIV incidence among men who have sex with men in Beijing, China. AIDS Care 2019, 32: 343-353. PMID: 31619058, PMCID: PMC6981072, DOI: 10.1080/09540121.2019.1679704.Peer-Reviewed Original ResearchConceptsVoluntary medical male circumcisionNew HIV casesMedical male circumcisionHIV incidenceHIV casesMale circumcisionSignificant public health impactHIV prevention interventionsPublic health impactCoverage ratePrevention interventionsNew infectionsEvidence baseMSMMenHealth impactsIncidenceCircumcisionLong-term impactFirst studyDifferent coverage ratesInfectionPrevalenceBaselineEffect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART)
Hayes RJ, Donnell D, Floyd S, Mandla N, Bwalya J, Sabapathy K, Yang B, Phiri M, Schaap A, Eshleman SH, Piwowar-Manning E, Kosloff B, James A, Skalland T, Wilson E, Emel L, Macleod D, Dunbar R, Simwinga M, Makola N, Bond V, Hoddinott G, Moore A, Griffith S, Deshmane Sista N, Vermund SH, El-Sadr W, Burns DN, Hargreaves JR, Hauck K, Fraser C, Shanaube K, Bock P, Beyers N, Ayles H, Fidler S. Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART). New England Journal Of Medicine 2019, 381: 207-218. PMID: 31314965, PMCID: PMC6587177, DOI: 10.1056/nejmoa1814556.Peer-Reviewed Original ResearchConceptsHIV-positive participantsViral suppressionHIV infectionGroup BGroup AGroup CMonth 12Universal testingPrevention interventionsPopulation cohortHuman immunodeficiency virus (HIV) infectionHome-based HIV testingBaseline HIV prevalenceCombination prevention interventionsImmunodeficiency virus infectionHIV-positive adultsPopulation-level incidenceNew HIV infectionsAdjusted rate ratiosCommunity-randomized trialLack of effectHIV carePrevious trial resultsStandard careART adherenceModeling economic and epidemiological impact of voluntary medical male circumcision among men who have sex with men in Beijing, China
Zhang C, Penson DF, Qian HZ, Webb GF, Lou J, Shephard BE, Liu Y, Vermund SH. Modeling economic and epidemiological impact of voluntary medical male circumcision among men who have sex with men in Beijing, China. International Journal Of STD & AIDS 2019, 30: 630-638. PMID: 30890118, PMCID: PMC6666307, DOI: 10.1177/0956462419831859.Peer-Reviewed Original ResearchConceptsVoluntary medical male circumcisionNew HIV casesMedical male circumcisionHIV casesMale circumcisionHIV/AIDS epidemicCoverage rateHIV acquisitionHIV incidenceCumulative numberCircumcision ratesDeterministic compartmental modelEpidemiological impactVMMC implementationAIDS epidemicMenMSMCircumcisionSexYearsCompartmental modelCasesIncidence
2017
Mortality in Children with Human Immunodeficiency Virus Initiating Treatment: A Six-Cohort Study in Latin America
Luque MT, Jenkins CA, Shepherd BE, Padgett D, Rouzier V, Succi RCM, Machado DM, McGowan CC, Vermund SH, Pinto JA. Mortality in Children with Human Immunodeficiency Virus Initiating Treatment: A Six-Cohort Study in Latin America. The Journal Of Pediatrics 2017, 182: 245-252.e1. PMID: 28081884, PMCID: PMC5328796, DOI: 10.1016/j.jpeds.2016.12.034.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-HIV AgentsAntiretroviral Therapy, Highly ActiveCause of DeathChildChild, PreschoolCohort StudiesConfidence IntervalsDatabases, FactualDose-Response Relationship, DrugDrug Administration ScheduleFemaleHIV InfectionsHumansIncidenceLatin AmericaMaleProportional Hazards ModelsRetrospective StudiesRisk AssessmentSeverity of Illness IndexSurvival AnalysisConceptsCombination antiretroviral therapyYears of ageCART initiationGreater riskCox proportional hazards modelAntiretroviral therapy-naïveMedian CD4 countRetrospective cohort studyProportional hazards modelCumulative mortality incidenceSouth America networkProbability of deathInitiating treatmentMedian CD4Antiretroviral therapyCause mortalityCD4 countTherapy-naïveCohort studyCumulative incidenceHIV epidemiologyPediatric careMortality incidenceHazards modelRegimens
2016
Rates and determinants of incidence and clearance of cervical HPV genotypes among HIV-seropositive women in Pune, India
Mane A, Sahasrabuddhe VV, Nirmalkar A, Risbud AR, Sahay S, Bhosale RA, Vermund SH, Mehendale SM. Rates and determinants of incidence and clearance of cervical HPV genotypes among HIV-seropositive women in Pune, India. Journal Of Clinical Virology 2016, 88: 26-32. PMID: 28152432, PMCID: PMC5441893, DOI: 10.1016/j.jcv.2016.10.013.Peer-Reviewed Original ResearchConceptsHIV-seropositive womenCervical HPV genotypesHPV genotypesClearance rateHPV infectionAge-related hormonal changesRoche Linear Array HPVAlpha-7 speciesAntiretroviral therapy statusCarcinogenic HPV genotypesCervical HPV infectionGenotype-specific prevalenceLinear Array HPVAge of participantsCD4 countHPV incidenceImmunologic factorsDeterminants of incidenceHPV typesTherapy statusProspective studyCervical samplesIncidence rateHormonal changesEtiologic studiesFrequent HIV Testing
Liu Y, Qian HZ, Ruan Y, Wu P, Osborn CY, Jia Y, Yin L, Lu H, He X, Shao Y, Vermund SH. Frequent HIV Testing. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 72: 452-461. PMID: 27003496, PMCID: PMC4925192, DOI: 10.1097/qai.0000000000001001.Peer-Reviewed Original ResearchConceptsMultivariable logistic regression analysisCurrent HIV infectionHIV incidence reductionHIV testing historyPropensity score adjustmentCubic spline modelingBorderline significant trendLogistic regression analysisHigher testing ratesHIV infectionHIV serostatusPrevious HIVHIV epidemicBeijing MSMTesting ratesScore adjustmentIncidence reductionTesting historyHIVInfection statusBehavioral factorsRegression analysisMSMOddsMenRisk Factors for Loss to Follow-Up among People Who Inject Drugs in a Risk Reduction Program at Karachi, Pakistan. A Case-Cohort Study
Samo RN, Agha A, Shah SA, Altaf A, Memon A, Blevins M, Qian HZ, Vermund SH. Risk Factors for Loss to Follow-Up among People Who Inject Drugs in a Risk Reduction Program at Karachi, Pakistan. A Case-Cohort Study. PLOS ONE 2016, 11: e0147912. PMID: 26840414, PMCID: PMC4739707, DOI: 10.1371/journal.pone.0147912.Peer-Reviewed Original ResearchConceptsCase-cohort studyMale PWIDHarm reduction programsRisk reduction programsRisk factorsReduction programsNeedle/syringe exchangeProspective cohort studyMultivariable logistic regressionResource-limited settingsHistory of incarcerationCohort studyMedian ageIncidence rateSyringe exchangePWIDMale peopleYounger ageLogistic regressionYoung menMonthsKarachiMenActive outreachProgrammatic challenges
2015
Pregnant women with HIV in rural Nigeria have higher rates of antiretroviral treatment initiation, but similar loss to follow-up as non-pregnant women and men
Aliyu MH, Blevins M, Megazzini KM, Parrish DD, Audet CM, Chan N, Odoh C, Gebi UI, Muhammad MY, Shepherd BE, Wester CW, Vermund SH. Pregnant women with HIV in rural Nigeria have higher rates of antiretroviral treatment initiation, but similar loss to follow-up as non-pregnant women and men. International Health 2015, 7: 405-411. PMID: 26012740, PMCID: PMC4654753, DOI: 10.1093/inthealth/ihv032.Peer-Reviewed Original ResearchConceptsNon-pregnant womenPregnant womenPregnancy statusCumulative incidenceART-naïve patientsEarly ART initiationPost-ART initiationAntiretroviral therapy initiationDays of enrollmentART-naïve HIVAntiretroviral treatment initiationRural NigeriaART initiationHigher CD4Therapy initiationTreatment initiationClinical stageCox regressionPatient groupPregnant clientsHIVLTFUWomenHigh rateSex
2014
Two-Year Death and Loss to Follow-Up Outcomes by Source of Referral to HIV Care for HIV-Infected Patients Initiating Antiretroviral Therapy in Rural Mozambique
Blevins M, José E, Bilhete FR, Vaz LM, Shepherd BE, Audet CM, Vermund SH, Moon TD. Two-Year Death and Loss to Follow-Up Outcomes by Source of Referral to HIV Care for HIV-Infected Patients Initiating Antiretroviral Therapy in Rural Mozambique. AIDS Research And Human Retroviruses 2014, 31: 198-207. PMID: 25381732, PMCID: PMC4532902, DOI: 10.1089/aid.2014.0007.Peer-Reviewed Original ResearchConceptsSource of referralCombination antiretroviral therapyRural Zambézia ProvinceReferral sitesAntiretroviral therapyAntenatal careGeneral outpatient clinicCumulative incidence estimatesAdditional unmeasured factorsCART initiationHIV careHazard ratioPatient characteristicsHIV testingMedian ageVoluntary counselingCox regressionOutpatient clinicKaplan-MeierPatient populationMedication pickupPatient outcomesInpatient careLTFUIncidence estimatesGlobal HIV Epidemiology: A Guide for Strategies in Prevention and Care
Vermund SH. Global HIV Epidemiology: A Guide for Strategies in Prevention and Care. Current HIV/AIDS Reports 2014, 11: 93-98. PMID: 24691698, PMCID: PMC4042676, DOI: 10.1007/s11904-014-0208-x.Peer-Reviewed Original ResearchConceptsRisk populationsFemale sex worker cohortSex worker cohortPrevention of motherOpiate substitution therapyHIV prevention strategiesConsiderable clinical benefitPublic health approachRepresentative population sampleLow infectiousnessAntiretroviral therapyChild transmissionHIV incidenceClinical benefitSubstitution therapyConcentrated epidemicsHIV epidemicSentinel populationYoung MSMPrevalence surveyGeneralized epidemicsIncidence estimatesNeedle useEffective carePrevention servicesModeling the Impact on HIV Incidence of Combination Prevention Strategies among Men Who Have Sex with Men in Beijing, China
Lou J, Blevins M, Ruan Y, Vermund SH, Tang S, Webb GF, Shepherd BE, He X, Lu H, Shao Y, Qian HZ. Modeling the Impact on HIV Incidence of Combination Prevention Strategies among Men Who Have Sex with Men in Beijing, China. PLOS ONE 2014, 9: e90985. PMID: 24626165, PMCID: PMC3953201, DOI: 10.1371/journal.pone.0090985.Peer-Reviewed Original ResearchConceptsAntiretroviral therapyHIV epidemicCondom useHIV prevalenceART coverageCombination prevention strategiesHIV/AIDSHIV testingHIV incidenceCombination interventionsBeijing MSMPrevention strategiesPrevalence estimatesPrevalenceEpidemic expansionMenInterventionEpidemicIncidenceBasic reproduction numberPrevention scenariosCurrent coverageSexReproduction numberIntervention levelsHPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial
Hayes R, Ayles H, Beyers N, Sabapathy K, Floyd S, Shanaube K, Bock P, Griffith S, Moore A, Watson-Jones D, Fraser C, Vermund SH, Fidler S, The HPTN 071 (PopART) Study Team. HPTN 071 (PopART): Rationale and design of a cluster-randomised trial of the population impact of an HIV combination prevention intervention including universal testing and treatment – a study protocol for a cluster randomised trial. Trials 2014, 15: 57. PMID: 24524229, PMCID: PMC3929317, DOI: 10.1186/1745-6215-15-57.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAnti-HIV AgentsCircumcision, MaleClinical ProtocolsCost-Benefit AnalysisDrug Administration ScheduleFemaleHealth Care CostsHIV InfectionsHumansIncidenceMaleMass ScreeningPredictive Value of TestsPrevalenceResearch DesignSouth AfricaTime FactorsTreatment OutcomeYoung AdultZambiaConceptsImmediate antiretroviral treatmentAntiretroviral treatmentHIV incidenceHIV testingCombination HIV prevention packageHIV combination prevention interventionsHome-based HIV testingUniversal testingCombination prevention interventionsHIV prevention packageHPTN 071 (PopART) trialUniversal HIV testingHIV-negative menCluster-randomised trialCurrent national guidelinesStandard of careMedical male circumcisionPublic health problemThree-arm designPotential adverse effectsART initiationHPTN 071Testing HIVSecondary outcomesArm B
2013
High HIV Incidence among Persons Who Inject Drugs in Pakistan: Greater Risk with Needle Sharing and Injecting Frequently among the Homeless
Samo RN, Altaf A, Agha A, Pasha O, Rozi S, Memon A, Azam S, Blevins M, Vermund SH, Shah SA. High HIV Incidence among Persons Who Inject Drugs in Pakistan: Greater Risk with Needle Sharing and Injecting Frequently among the Homeless. PLOS ONE 2013, 8: e81715. PMID: 24358123, PMCID: PMC3864804, DOI: 10.1371/journal.pone.0081715.Peer-Reviewed Original ResearchConceptsIncidence of HIVHIV seroconversionIncidence rateMultivariable Cox regression analysisNeedle/syringe exchangeCohort of PWIDHIV-seronegative personsHigh HIV incidenceOpiate substitution therapyCox regression analysisHIV incidence ratesHIV risk reductionSharing of syringesRisk reductionSubstance abuse treatmentSeronegative personsCohort studyRisk reduction programsHIV incidencePerson yearsSubstitution therapyDaily injectionsNeedle sharingRisk factorsPrevalence ratesCan Combination Prevention Strategies Reduce HIV Transmission in Generalized Epidemic Settings in Africa? The HPTN 071 (PopART) Study Plan in South Africa and Zambia
Vermund SH, Fidler SJ, Ayles H, Beyers N, Hayes RJ. Can Combination Prevention Strategies Reduce HIV Transmission in Generalized Epidemic Settings in Africa? The HPTN 071 (PopART) Study Plan in South Africa and Zambia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2013, 63: s221-s227. PMID: 23764639, PMCID: PMC3739051, DOI: 10.1097/qai.0b013e318299c3f4.Peer-Reviewed Original ResearchConceptsHIV Prevention Trials NetworkHPTN 071 (PopART) studyHPTN 071HIV incidenceHIV transmissionHome-based HIV testingVoluntary medical male circumcisionGeneralized epidemic settingsLinkage of HIVUniversal antiretroviral therapyChild HIV transmissionPrevention of motherHIV viral loadCommunity health workersMedical male circumcisionCommunity-randomized trialIntervention strategiesCombination prevention strategiesAntiretroviral therapyHIV acquisitionSeropositive personsTuberculosis servicesHIV testingViral loadTuberculosis transmission
2011
Prevalence, Incidence, and Recurrence of Oral Lesions Among HIV-Infected Patients on HAART in Alabama
Tamí-Maury IM, Willig JH, Jolly PE, Vermund S, Aban I, Hill JD, Wilson CM, Kempf MC. Prevalence, Incidence, and Recurrence of Oral Lesions Among HIV-Infected Patients on HAART in Alabama. Southern Medical Journal 2011, 104: 561-566. PMID: 21886064, DOI: 10.1097/smj.0b013e318224a15f.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAIDS-Related Opportunistic InfectionsAlabamaAntiretroviral Therapy, Highly ActiveCandidiasis, OralFemaleHIV InfectionsHumansIncidenceLeukoplakia, HairyLongitudinal StudiesMaleMiddle AgedMouth DiseasesOffice VisitsOral UlcerPrevalenceRecurrenceRetrospective StudiesStomatitis, HerpeticYoung AdultConceptsOral lesionsOropharyngeal candidiasisPeriod prevalenceOral conditionsActive antiretroviral therapyAvailability of HAARTLaboratory dataYears of agePatient's laboratory dataAntiretroviral therapyChart reviewHIV infectionRetrospective studyFrequent manifestationIncidence rateMedical careHAARTNew casesPatientsRecurrencePrevalenceIncident rateUniversity of AlabamaHIVLesions