2009
Reduced nucleus pulposus glycosaminoglycan content alters intervertebral disc dynamic viscoelastic mechanics
Boxberger JI, Orlansky AS, Sen S, Elliott DM. Reduced nucleus pulposus glycosaminoglycan content alters intervertebral disc dynamic viscoelastic mechanics. Journal Of Biomechanics 2009, 42: 1941-1946. PMID: 19539936, PMCID: PMC2756063, DOI: 10.1016/j.jbiomech.2009.05.008.Peer-Reviewed Original ResearchConceptsDynamic stiffnessCompressive loadEquilibrium loadHigh dynamic stiffnessDynamic loading regimesPhase angleDynamic viscoelastic propertiesMechanical behaviorAxial loadViscoelastic mechanicsOscillatory loadingLoading regimesLow loadViscoelastic propertiesDynamic mechanicsLumbar motion segmentsMechanical mechanismDisc mechanicsStiffnessLoadSpectrum of frequenciesPossible mechanical mechanismsReduced glycosaminoglycansMotion segmentsMechanics
2008
Comparison of Animal Discs Used in Disc Research to Human Lumbar Disc
Beckstein JC, Sen S, Schaer TP, Vresilovic EJ, Elliott DM. Comparison of Animal Discs Used in Disc Research to Human Lumbar Disc. Spine 2008, 33: e166-e173. PMID: 18344845, DOI: 10.1097/brs.0b013e318166e001.Peer-Reviewed Original ResearchAn In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc
Boxberger JI, Auerbach JD, Sen S, Elliott DM. An In Vivo Model of Reduced Nucleus Pulposus Glycosaminoglycan Content in the Rat Lumbar Intervertebral Disc. Spine 2008, 33: 146-154. PMID: 18197098, PMCID: PMC2696404, DOI: 10.1097/brs.0b013e31816054f8.Peer-Reviewed Original ResearchConceptsRange of motionVivo modelDisc degenerationEarly stage disc degenerationRat lumbar intervertebral discsRat lumbar spineDevelopment of therapiesIntervertebral disc degenerationLumbar intervertebral discsHistology 4Glycosaminoglycan contentDisease progressionBACKGROUND DATALumbar spineAnimal modelsAltered biochemistryEarly interventionGlycosaminoglycan levelsGlycosaminoglycan lossPhysiologic levelsDegenerationControl levelsIntervertebral discNucleus pulposusWeeks
2006
Nucleus pulposus glycosaminoglycan content is correlated with axial mechanics in rat lumbar motion segments
Boxberger JI, Sen S, Yerramalli CS, Elliott DM. Nucleus pulposus glycosaminoglycan content is correlated with axial mechanics in rat lumbar motion segments. Journal Of Orthopaedic Research® 2006, 24: 1906-1915. PMID: 16865712, DOI: 10.1002/jor.20221.Peer-Reviewed Original Research