2021
Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development
Xia S, VanKuren NW, Chen C, Zhang L, Kemkemer C, Shao Y, Jia H, Lee U, Advani AS, Gschwend A, Vibranovski MD, Chen S, Zhang YE, Long M. Genomic analyses of new genes and their phenotypic effects reveal rapid evolution of essential functions in Drosophila development. PLOS Genetics 2021, 17: e1009654. PMID: 34242211, PMCID: PMC8270118, DOI: 10.1371/journal.pgen.1009654.Peer-Reviewed Original ResearchConceptsNew genesPhenotypic effectsEssential functionsLong evolutionary time scalesDevelopment of DrosophilaEvolutionary time scalesDrosophila developmentDrosophila genusEssential genesGene essentialityRNAi libraryYoung genesGenomic analysisCRISPR knockoutKnockout approachGenetic basisKnockdown experimentsComputational identificationGene effectsGenesDuplicate copiesRapid evolutionDrosophilaKnockdown efficiencyDistant ancestors
2013
New Gene Evolution: Little Did We Know
Long M, VanKuren NW, Chen S, Vibranovski MD. New Gene Evolution: Little Did We Know. Annual Review Of Genetics 2013, 47: 307-333. PMID: 24050177, PMCID: PMC4281893, DOI: 10.1146/annurev-genet-111212-133301.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBrainDrosophila melanogasterEvolution, MolecularForecastingGene DosageGene DuplicationGene Expression RegulationGene Regulatory NetworksGene Transfer, HorizontalGenesGenes, InsectGenes, PlantGenetic StructuresHumansMammalsModels, GeneticPhenotypePhylogenyRecombination, GeneticRNA, UntranslatedSelection, GeneticSex CharacteristicsTranscription, GeneticConceptsNew gene originationNew genesGene originationGenetic systemNew gene evolutionNew gene structuresGene evolutionPhenotypic evolutionGene structureDifferent organismsBiological diversityPhenotypic functionsGenesGenomeOriginationEvolutionDecades of effortOrganismsDiversityComprehensive pictureCritical component
2011
Roles of young serine-endopeptidase genes in survival and reproduction revealed rapid evolution of phenotypic effects at adult stages
Chen S, Yang H, Krinsky BH, Zhang A, Long M. Roles of young serine-endopeptidase genes in survival and reproduction revealed rapid evolution of phenotypic effects at adult stages. Fly 2011, 5: 345-351. PMID: 21946255, PMCID: PMC3266076, DOI: 10.4161/fly.5.4.17808.Peer-Reviewed Original ResearchConceptsYoung genesConstitutive knockdownAdult stageD. melanogaster subgroupEvolution of developmentImportant functional roleMelanogaster subgroupDrosophila melanogasterLethal phenotypeNew genesCommon ancestorImportant traitsNatural selectionEndopeptidase genePhenotypic effectsLife historyWildtype levelsMultiple phenotypesGenesFunctional roleGenetic componentRapid evolutionMale fertilityFemale fertilityKnockdown
2010
New Genes in Drosophila Quickly Become Essential
Chen S, Zhang YE, Long M. New Genes in Drosophila Quickly Become Essential. Science 2010, 330: 1682-1685. PMID: 21164016, PMCID: PMC7211344, DOI: 10.1126/science.1196380.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SubstitutionAnimalsBody PatterningDrosophilaDrosophila melanogasterDrosophila ProteinsEvolution, MolecularGene DuplicationGene Expression ProfilingGene Expression Regulation, DevelopmentalGenes, EssentialGenes, InsectLarvaMetamorphosis, BiologicalPhenotypePhylogenyPupaRNA InterferenceTime FactorsWings, Animal