2023
Pooled screening with next-generation gene editing tools
Zhou L, Yang L, Feng Y, Chen S. Pooled screening with next-generation gene editing tools. Current Opinion In Biomedical Engineering 2023, 28: 100479. PMID: 38222973, PMCID: PMC10786633, DOI: 10.1016/j.cobme.2023.100479.Peer-Reviewed Original ResearchGene editing toolsEditing toolsFunction of genesShort palindromic repeatsPooled screensPalindromic repeatsGenetic elementsPool of cellsBiological processesPooled screeningGenetic variantsPotential targetRecent advancesGenesRepeatsPlantsSequencingMutationsAgricultural researchTherapeutic interventionsSimultaneous examinationExpressionPotential future directionsCellsPool
2021
Metaviromic identification of discriminative genomic features in SARS-CoV-2 using machine learning
Park JJ, Chen S. Metaviromic identification of discriminative genomic features in SARS-CoV-2 using machine learning. Patterns 2021, 3: 100407. PMID: 34812427, PMCID: PMC8598947, DOI: 10.1016/j.patter.2021.100407.Peer-Reviewed Original ResearchAmino acid resolutionSARS-CoV-2 genomeGenomic featuresGenetic elementsCoronavirus genomeGenomeFunctional studiesSequence targetsGenomic profilesUnbiased collectionMajor threatPathogenic virusesUnappreciated featureAnimal originInterpretable signaturesRapid characterizationPathogenic regionsSARS-CoVB cellsSystematic mapRdRpNucleotidesEpitope predictionProteinPathogenicity