2012
Adaptive Evolution and the Birth of CTCF Binding Sites in the Drosophila Genome
Ni X, Zhang YE, Nègre N, Chen S, Long M, White KP. Adaptive Evolution and the Birth of CTCF Binding Sites in the Drosophila Genome. PLOS Biology 2012, 10: e1001420. PMID: 23139640, PMCID: PMC3491045, DOI: 10.1371/journal.pbio.1001420.Peer-Reviewed Original ResearchMeSH KeywordsAdaptation, BiologicalAnimalsBase SequenceBinding SitesCCCTC-Binding FactorConserved SequenceDrosophilaDrosophila ProteinsEvolution, MolecularGenetic DriftGenetics, PopulationGenome, InsectOligonucleotide Array Sequence AnalysisPhylogenyProtein BindingRepressor ProteinsSelection, GeneticSpecies SpecificityTime FactorsConceptsCTCF binding siteDrosophila melanogasterNew genesCis-regulatory DNA sequencesGene expressionSpecies of DrosophilaGenome-wide bindingSignatures of selectionGenomes of humansComparative gene expression profilingGenome sequence dataRecent common ancestorGene expression profilingBinding sitesExpression divergenceGenome evolutionAdaptive evolutionDrosophila genomeDrosophila simulansEvolutionary ratesCTCF bindingCTCF proteinEvolutionary distanceNew CTCFCommon ancestor
2011
Roles of young serine-endopeptidase genes in survival and reproduction revealed rapid evolution of phenotypic effects at adult stages
Chen S, Yang H, Krinsky BH, Zhang A, Long M. Roles of young serine-endopeptidase genes in survival and reproduction revealed rapid evolution of phenotypic effects at adult stages. Fly 2011, 5: 345-351. PMID: 21946255, PMCID: PMC3266076, DOI: 10.4161/fly.5.4.17808.Peer-Reviewed Original ResearchConceptsYoung genesConstitutive knockdownAdult stageD. melanogaster subgroupEvolution of developmentImportant functional roleMelanogaster subgroupDrosophila melanogasterLethal phenotypeNew genesCommon ancestorImportant traitsNatural selectionEndopeptidase genePhenotypic effectsLife historyWildtype levelsMultiple phenotypesGenesFunctional roleGenetic componentRapid evolutionMale fertilityFemale fertilityKnockdownHighly Tissue Specific Expression of Sphinx Supports Its Male Courtship Related Role in Drosophila melanogaster
Chen Y, Dai H, Chen S, Zhang L, Long M. Highly Tissue Specific Expression of Sphinx Supports Its Male Courtship Related Role in Drosophila melanogaster. PLOS ONE 2011, 6: e18853. PMID: 21541324, PMCID: PMC3082539, DOI: 10.1371/journal.pone.0018853.Peer-Reviewed Original ResearchMeSH KeywordsAnimal StructuresAnimalsBase PairingBase SequenceBrainConserved SequenceCourtshipDrosophila melanogasterFemaleGene Expression ProfilingGene Expression RegulationGenome, InsectGreen Fluorescent ProteinsMaleMolecular Sequence DataMutationOrgan SpecificityPeripheral Nervous SystemPromoter Regions, GeneticRNA, UntranslatedSexual Behavior, AnimalTransformation, GeneticConceptsDrosophila melanogasterBp regionCourtship behaviorNon-coding RNA genesWhole genome expression profilingBp upstream regionTissue-specific expressionGenome expression profilingMale courtship behaviorMale accessory glandsMelanogaster subgroupDrosophila speciesD. virilisRNA genesGene categoriesProtein functionKnockout mutationsWing hairsMale courtshipTarget genesExpression profilingGFP signalNegative regulatorEnhancer elementsExpression signals
2008
The evolution of courtship behaviors through the origination of a new gene in Drosophila
Dai H, Chen Y, Chen S, Mao Q, Kennedy D, Landback P, Eyre-Walker A, Du W, Long M. The evolution of courtship behaviors through the origination of a new gene in Drosophila. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 7478-7483. PMID: 18508971, PMCID: PMC2396706, DOI: 10.1073/pnas.0800693105.Peer-Reviewed Original ResearchConceptsMale-male courtshipD. melanogasterChimeric geneCourtship behaviorNew genesRelated Drosophila speciesNew chimeric genesDrosophila speciesAdaptive evolutionMutant phenotypeDrosophila melanogasterAncestral conditionUnrelated genesPhenotypic effectsMelanogasterNovel phenotypesCombination of sequenceMating behaviorChimeric structureGenesCourtshipSpeciesPhenotypeDrosophilaKnockout