2024
Prior tuberculosis, radiographic lung abnormalities and prevalent diabetes in rural South Africa
Castle A, Moosa Y, Claassen H, Shenoi S, Magodoro I, Manne-Goehler J, Hanekom W, Bassett I, Wong E, Siedner M. Prior tuberculosis, radiographic lung abnormalities and prevalent diabetes in rural South Africa. BMC Infectious Diseases 2024, 24: 690. PMID: 38992607, PMCID: PMC11238449, DOI: 10.1186/s12879-024-09583-8.Peer-Reviewed Original ResearchConceptsPrevalent diabetesChest X-rayChest X-ray abnormalitiesX-ray abnormalitiesOdds of prevalent diabetesHemoglobin A1c testingPost-TB lung diseaseHistory of TB diseaseAssociated with prevalent diabetesPulmonary abnormalitiesExposure of interestRural South AfricaPrevalence of diabetesTB diseaseCohort of peopleCAD4TBMethodsWe analyzed dataCross-sectional studyCompare groupsLogistic regression modelsIncidence of diabetesDiabetes prevalenceA1c testingConclusionsAmong peopleDigital chest X-ray
2022
Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients
Ortigoza MB, Yoon H, Goldfeld KS, Troxel AB, Daily JP, Wu Y, Li Y, Wu D, Cobb GF, Baptiste G, O’Keeffe M, Corpuz MO, Ostrosky-Zeichner L, Amin A, Zacharioudakis IM, Jayaweera DT, Wu Y, Philley JV, Devine MS, Desruisseaux MS, Santin AD, Anjan S, Mathew R, Patel B, Nigo M, Upadhyay R, Kupferman T, Dentino AN, Nanchal R, Merlo CA, Hager DN, Chandran K, Lai JR, Rivera J, Bikash CR, Lasso G, Hilbert TP, Paroder M, Asencio AA, Liu M, Petkova E, Bragat A, Shaker R, McPherson DD, Sacco RL, Keller MJ, Grudzen CR, Hochman JS, Pirofski LA, Rahman F, Ajayi A, Rodriguez S, Ledesma A, Keeling D, Rappoport N, Ebel S, Kim J, Chang M, Chan K, Patel P, Martocci A, Dave S, Darwish Y, Taveras M, Shoyelu V, Xin P, Iturrate E, Moldolsky L, Raimondo B, Mendez S, Hughes P, Sterling S, Lord A, Yaghi S, Veloso K, Sheikh M, Visconti-Ferrara E, Fleming A, Youn H, Jane Fran B, Medina R, McKell R, Khan S, Hamilton T, Sanchez C, Patel N, Cleare L, Vergnolle O, Nakouzi A, Quevedo G, Bortz R, Wirchnianski A, Florez C, Babb R, Ayala J, Tsagaris K, James A, Eke I, Obeidallah A, Sandu O, Sohval S, Serrano-Rahman L, Uehlinger J, Bartash R, Al-Abduladheem A, Gendlina I, Sheridan C, Bortnick A, Eichler J, Kaufman R, Yukelis S, Pennock M, Goggin M, Shen C, Annam J, Khokhar A, Barboto D, Lally B, Lee A, Lee M, Yang X, Allen S, Malaviya A, Moussa O, Park R, Sample R, Bae A, Benoni G, Boerger L, Baker L, Luther M, Ameti L, Briggs N, Golden M, Gormally M, Huang G, Johnson R, Morrison A, Montagna-Hill M, Rivera B, Cortezzo G, Debski K, Nicoletti, DeBenedictis K, Davis R, Marshall C, Duque Cuartas M, Beauchamps L, Bertran-Lopez J, Gonzales Zamora J, Delgado-Lelievre M, Dominguez S, Lee C, Kusack H, Karakeshishyan V, Hajaz A, Deniz D, Garcia G, Dae K, Blenet P, Jaffe D, Olson L, Sabogal D, Blust O, Del Prete Perez V, Bornia C, Rodriguez-Perez V, Calderon V, Ramdev R, Jolly A, Guzman I, Guerra R, Brito S, Hobbs R, Denham R, Dick J, Hernandez M, Nielsen L, Anjum S, Mader S, Stutz T, Mammadova M, Nichols P, Khan T, Boktour M, Castaneda B, Benitez B, Hinojosa E, Guerra B, Ortiz A, Hebbeler-Clark R, McShane P, Hibbard R, Hawkins B, Dohanich E, Wadle C, Greenlee K, Brooks J, Herrick C, Gode A, Bergl P, Hu K, Patel J, Srinivasan S, Graf J, Klis C, Reimer K, Carpenter E, Naczek C, Petersen R, Dex R, Drossart J, Zelten J, Brummitt C, Liang M, Yanny L, Dennison G, Runningen P, Brzezinski B, Fiebig S, Naczek C, Kasdorf M, Parameswaran L, Corcoran A, Rohatgi A, Wronska M, Wu X, Srinivasan R, Deng F, Filardo T, Pendse J, Blaser S, Whyte O, Gallagher J, Thomas O, Ramos D, Sturm-Reganato C, Fong C, Daus I, Payoen A, Chiofolo J, Friedman M, Wu D, Jacobson J, Schneider J, Sarwar U, Wang H, Huebinger R, Dronavalli G, Bai Y, Grimes C, Eldin K, Umana V, Martin J, Heath T, Bello F, Ransford D, Laurent-Rolle M, Shenoi S, Akide-Ndunge O, Thapa B, Peterson J, Knauf K, Patel S, Cheney L, Tormey C, Hendrickson J. Efficacy and Safety of COVID-19 Convalescent Plasma in Hospitalized Patients. JAMA Internal Medicine 2022, 182: 115-126. PMID: 34901997, PMCID: PMC8669605, DOI: 10.1001/jamainternmed.2021.6850.Peer-Reviewed Original ResearchConceptsCCP recipientsPlacebo recipientsSecondary outcomesSymptom durationHospitalized patientsPrimary outcomeDay 28COVID-19SARS-CoV-2 serostatusSARS-CoV-2 titersWorld Health Organization (WHO) ordinal scaleCOVID-19 convalescent plasmaConvalescent plasma usePlacebo-controlled trialLess daysExploratory subgroup analysisNon-Hispanic blacksSARS-CoV-2CCP efficacyConcomitant medicationsAdverse eventsClinical improvementSymptom onsetConvalescent plasmaMedian age
2021
Cumulative burden of non-communicable diseases predicts COVID hospitalization among people with HIV: A one-year retrospective cohort study
Virata MD, Shenoi SV, Ladines-Lim J, Villanueva MS, Barakat LA. Cumulative burden of non-communicable diseases predicts COVID hospitalization among people with HIV: A one-year retrospective cohort study. PLOS ONE 2021, 16: e0260251. PMID: 34851963, PMCID: PMC8635326, DOI: 10.1371/journal.pone.0260251.Peer-Reviewed Original ResearchConceptsOne-year retrospective cohort studyCohort of PWHNon-communicable comorbiditiesPredictors of hospitalizationRetrospective cohort studyChronic lung diseaseLikelihood of hospitalizationSingle-site experienceCOVID-19 infectionNon-communicable diseasesOutcomes of peopleCohort studyHIV diseaseOverall mortalityClinical outcomesLung diseaseCardiovascular diseaseHospitalizationCumulative burdenHIVLater timeframeDiseaseEarly epidemicPWHOutcomesAn expanding HIV epidemic among older adults in Ukraine: Implications for patient-centered care
Rozanova J, Zeziulin O, Rich KM, Altice FL, Kiriazova T, Zaviryukha I, Sosidko T, Gulati K, Carroll C, Shenoi SV. An expanding HIV epidemic among older adults in Ukraine: Implications for patient-centered care. PLOS ONE 2021, 16: e0256627. PMID: 34591848, PMCID: PMC8483339, DOI: 10.1371/journal.pone.0256627.Peer-Reviewed Original ResearchConceptsStandardized mortality ratioMortality rateCause standardized mortality ratioTime of diagnosisGeneral population ratesLate-stage HIVAge-matched groupHigh mortality ratePatient-centered careIncident HIVHIV diagnosisHIV testingHIV incidenceHIV treatmentHIV epidemicMortality ratioTreatment strategiesGeneral populationHIVMortality trendsAge groupsEECA countriesTreatment programSame calendar yearOlder peopleFactors associated with low tuberculosis preventive therapy prescription rates among health care workers in rural South Africa
Ahmed AA, Grammatico M, Moll AP, Malinga S, Makhunga P, Charalambous S, Ladines-Lim JB, Jones J, Choi K, Shenoi SV. Factors associated with low tuberculosis preventive therapy prescription rates among health care workers in rural South Africa. Global Health Action 2021, 14: 1979281. PMID: 34652990, PMCID: PMC8525921, DOI: 10.1080/16549716.2021.1979281.Peer-Reviewed Original ResearchConceptsTuberculosis preventive therapyHealth care workersPrimary healthcare clinicsLower prescription ratesPrescription ratesRural South AfricaCare workersIsoniazid preventative therapyIncidence of tuberculosisCross-sectional studyGovernment district hospitalsPreventive therapyMedian ageMultivariable analysisPreventative therapyDistrict hospitalHealthcare clinicsHCW trainingPatient disclosureTPT useConsolidated FrameworkLogistic regressionImplementation researchSelf-reported dataPrescribers
2020
Social Support is Key to Retention in Care during Covid-19 Pandemic among Older People with HIV and Substance Use Disorders in Ukraine
Rozanova J, Shenoi S, Zaviryukha I, Zeziulin O, Kiriazova T, Rich K, Mamedova E, Yariy V. Social Support is Key to Retention in Care during Covid-19 Pandemic among Older People with HIV and Substance Use Disorders in Ukraine. Substance Use & Misuse 2020, 55: 1902-1904. PMID: 32666857, PMCID: PMC7523433, DOI: 10.1080/10826084.2020.1791183.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAnti-Retroviral AgentsBetacoronavirusComorbidityCoronavirus InfectionsCOVID-19FemaleHealth PersonnelHIV InfectionsHumansMaleMiddle AgedPandemicsPneumonia, ViralRetention in CareSARS-CoV-2Social IsolationSocial SupportSubstance-Related DisordersSurveys and QuestionnairesUkraineConceptsSubstance use disordersUse disordersHuman immunodeficiency virus HIVCOVID-19 pandemicOlder peopleLay health workersSocial supportTreatment interruptionConclusions/Health workersSUD treatmentPharmacological approachesYears old accountTelehealth supportVirus HIVHIVOlder adultsDisordersSuch interventionsPhone surveyTherapyProvision of supportCOVID-19 lockdownPandemicOld accountAttenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient on Ruxolitinib
Foss FM, Rubinowitz A, Landry ML, Isufi I, Gowda L, Seropian S, Perreault S, Shenoi SV. Attenuated Novel SARS Coronavirus 2 Infection in an Allogeneic Hematopoietic Stem Cell Transplant Patient on Ruxolitinib. Clinical Lymphoma Myeloma & Leukemia 2020, 20: 720-723. PMID: 32727701, PMCID: PMC7316063, DOI: 10.1016/j.clml.2020.06.014.Peer-Reviewed Original ResearchMeSH KeywordsBetacoronavirusCoronavirus InfectionsCOVID-19COVID-19 Drug TreatmentGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansImmunocompromised HostLymphoma, T-CellMaleMiddle AgedNitrilesPandemicsPneumonia, ViralPyrazolesPyrimidinesSARS-CoV-2Severity of Illness IndexTransplantation, HomologousTreatment OutcomeConceptsAllogeneic hematopoietic stem cell transplant patientsHematopoietic stem cell transplant patientsSevere acute respiratory syndrome coronavirus 2SARS coronavirus 2 (SARS-CoV-2) infectionSARS-CoV-2 pneumoniaAcute respiratory syndrome coronavirus 2Stem cell transplant patientsSARS-CoV-2 infectionRespiratory syndrome coronavirus 2Coronavirus 2 infectionCell transplant patientsCoV-2 infectionStem cell transplantationSyndrome coronavirus 2High death rateImmunocompromised stateJAK/STAT inhibitor ruxolitinibTransplant patientsCell transplantationCoronavirus 2Novel therapiesInhibitor ruxolitinibPatientsDeath rateRuxolitinib
2018
Synergism between diabetes and human immunodeficiency virus in increasing the risk of tuberculosis
Sinha P, Moll AP, Brooks RP, Deng YH, Shenoi SV. Synergism between diabetes and human immunodeficiency virus in increasing the risk of tuberculosis. The International Journal Of Tuberculosis And Lung Disease 2018, 22: 793-799. PMID: 29914606, PMCID: PMC6050202, DOI: 10.5588/ijtld.17.0936.Peer-Reviewed Original ResearchConceptsRisk of tuberculosisDiabetes mellitusTB symptomsOdds ratioHuman immunodeficiency virus (HIV) infectionImmunodeficiency virus infectionHuman immunodeficiency virusCommunity health screeningCross-sectional studyCommunity health projectsActive tuberculosisHIV infectionHIV positivityPrimary outcomeImmunodeficiency virusScreening servicesHealth screeningCongregate settingsVirus infectionResource-limited regionsMultiplicative scaleHIVMultivariate analysisRetrospective dataTuberculosis
2017
Predictors of loss to follow-up among patients on ART at a rural hospital in KwaZulu-Natal, South Africa
Arnesen R, Moll AP, Shenoi SV. Predictors of loss to follow-up among patients on ART at a rural hospital in KwaZulu-Natal, South Africa. PLOS ONE 2017, 12: e0177168. PMID: 28542309, PMCID: PMC5443492, DOI: 10.1371/journal.pone.0177168.Peer-Reviewed Original ResearchConceptsPrimary health clinicsPredictors of lossART clinicsSouth African HIV clinicAntiretroviral therapy accessInadequate medical recordsCells/μLART initiationLow CD4LTFU ratesCD4 countHIV careHIV clinicHIV outcomesRetrospective reviewMedical recordsHealth clinicsTherapy accessHigh riskLTFUPatientsRural hospitalsRural South AfricaNovel interventionsClinic
2016
Characterizing Patients with Very-Low-Level HIV Viremia: A Community-Based Study
Helou E, Shenoi S, Kyriakides T, Landry ML, Kozal M, Barakat LA. Characterizing Patients with Very-Low-Level HIV Viremia: A Community-Based Study. Journal Of The International Association Of Providers Of AIDS Care (JIAPAC) 2016, 16: 261-266. PMID: 27903948, PMCID: PMC5423832, DOI: 10.1177/2325957416680028.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsCD4 Lymphocyte CountFemaleHIV InfectionsHIV-1HumansMaleMiddle AgedViral LoadViremiaConceptsVirologic failureViral load levelsPill burdenAlcohol useHuman immunodeficiency virus (HIV) careLow-level HIV viremiaUndetectable viral load levelsAntiretroviral regimen changesAntiretroviral therapy changesExperienced virologic failureLow-level viremiaIntravenous drug useSubset of patientsFrequent clinic visitsPoor clinical outcomePossible risk factorsHepatitis C virusHIV viremiaMore comorbiditiesNonfailure groupVirologic suppressionVirological failureCD4 countConsecutive chartsClinic visits
2015
What motivates use of community-based human immunodeficiency virus testing in rural South Africa?
Upadhya D, Moll AP, Brooks RP, Friedland G, Shenoi SV. What motivates use of community-based human immunodeficiency virus testing in rural South Africa? International Journal Of STD & AIDS 2015, 27: 662-671. PMID: 26134323, PMCID: PMC4851612, DOI: 10.1177/0956462415592789.Peer-Reviewed Original ResearchConceptsHIV testingRural South AfricaRural resource-limited settingsHuman immunodeficiency virus (HIV) testingCommunity-based HIVCommunity-based testingMedian CD4 countRecent HIV exposureCommunity-based HIV testing programmeFirst-time testersHIV testing programsVoluntary HIV testingResource-limited settingsCD4 countHIV exposureMedian ageHIV statusVirus testingCommunity testingHIVCells/Rural settingsFamily membersSix-itemRisky lifestylesTrends in hospital deaths among human immunodeficiency virus–infected patients during the antiretroviral therapy era, 1995 to 2011
Cowell A, Shenoi SV, Kyriakides TC, Friedland G, Barakat LA. Trends in hospital deaths among human immunodeficiency virus–infected patients during the antiretroviral therapy era, 1995 to 2011. Journal Of Hospital Medicine 2015, 10: 608-614. PMID: 26130520, PMCID: PMC4560992, DOI: 10.1002/jhm.2409.Peer-Reviewed Original ResearchConceptsHospital deathAIDS deathsHuman immunodeficiency virus-infected patientsHigher CD4 cell countsAIDS infectionAntiretroviral therapy eraNon-AIDS deathsNon-AIDS malignanciesCD4 cell countHIV viral loadVirus-infected patientsHuman immunodeficiency virusUrban teaching hospitalTimes greater likelihoodCardiovascular comorbiditiesTherapy eraCD4 countInpatient mortalityImmunodeficiency syndromeLiver diseaseUnderlying liverViral loadImmunodeficiency virusMedical recordsAntiretroviral eraIntegrating Community-Based Interventions to Reverse the Convergent TB/HIV Epidemics in Rural South Africa
Gilbert JA, Long EF, Brooks RP, Friedland GH, Moll AP, Townsend JP, Galvani AP, Shenoi SV. Integrating Community-Based Interventions to Reverse the Convergent TB/HIV Epidemics in Rural South Africa. PLOS ONE 2015, 10: e0126267. PMID: 25938501, PMCID: PMC4418809, DOI: 10.1371/journal.pone.0126267.Peer-Reviewed Original ResearchConceptsTB/HIVHIV control strategiesMDR-TBXDR-TBHIV deathsHIV casesHIV epidemicRural South AfricaTB/HIV casesTB treatment delayIsoniazid preventive therapyDrug-resistant TBHIV treatment programsTreatment cure ratesHIV case findingHIV control effortsNovel screening programPreventive therapyTB casesTB treatmentTreatment delayHIV transmissionCure rateQuestionnaire's sensitivityScreening programCare of the patient with XDR-TB who has failed treatment
Jacobson KB, Tate M, Eksteen F, Moll A, Padayatchi N, Friedland G, Shenoi S. Care of the patient with XDR-TB who has failed treatment. The Lancet Respiratory Medicine 2015, 3: 269-270. PMID: 25890645, PMCID: PMC4498160, DOI: 10.1016/s2213-2600(15)00109-5.Peer-Reviewed Original Research
2014
Disseminated tuberculosis manifesting as cholestasis in a patient with AIDS: a presentation to remember
Lee TM, Shenoi SV, Ogbuagu O. Disseminated tuberculosis manifesting as cholestasis in a patient with AIDS: a presentation to remember. BMJ Case Reports 2014, 2014: bcr2013201824. PMID: 24567181, PMCID: PMC3939406, DOI: 10.1136/bcr-2013-201824.Peer-Reviewed Case Reports and Technical NotesConceptsDisseminated tuberculosisCT scanChronic untreated HIV infectionSubsequent CT scanUntreated HIV infectionGeneXpert PCRMiliary infiltratesUnremarkable workupInduced sputumPersistent feverCholestatic jaundiceHIV infectionInfectious etiologyLiver diseasePleural effusionUnusual presentationTuberculosisCholestasisMycobacterium tuberculosisWeight lossJaundicePatientsIndian descentAIDSPresentation
2013
Initial diagnosis of HIV/AIDS in a 56-year-old man with non-healing forearm lesion
Zapata HJ, Villanueva M, Shenoi S. Initial diagnosis of HIV/AIDS in a 56-year-old man with non-healing forearm lesion. BMJ Case Reports 2013, 2013: bcr2013201184. PMID: 24248316, PMCID: PMC3841407, DOI: 10.1136/bcr-2013-201184.Peer-Reviewed Case Reports and Technical NotesConceptsForearm lesionPatient underwent incisionHIV viral loadMonths of treatmentSignificant medical problemHIV/AIDSEmpiric antibioticsAntiretroviral therapyCD4 countUnderwent incisionInitial diagnosisViral loadStarry stainImmunohistochemistry testingCopies/Bacillary angiomatosisHispanic menMedical problemsLesionsBartonella quintanaCells/PatientsMenHIVAngiomatosis
2012
Survival from XDR-TB Is Associated with Modifiable Clinical Characteristics in Rural South Africa
Shenoi SV, Brooks RP, Barbour R, Altice FL, Zelterman D, Moll AP, Master I, van der Merwe TL, Friedland GH. Survival from XDR-TB Is Associated with Modifiable Clinical Characteristics in Rural South Africa. PLOS ONE 2012, 7: e31786. PMID: 22412840, PMCID: PMC3295798, DOI: 10.1371/journal.pone.0031786.Peer-Reviewed Original ResearchConceptsXDR-TB patientsDrug-resistant tuberculosisRetrospective case-control studyXDR-TB casesCommunity-based hospitalCase-control studyGlobal public healthHIV coinfectionMicrobiological correlatesModifiable factorsAvailable interventionsRural South AfricaControl studyPatientsTuberculosisPublic healthSurvivorsSurvivalDaysHospitalMortality