2024
Considerations when prescribing opioid agonist therapies for people living with HIV
Tarfa A, Lier A, Shenoi S, Springer S. Considerations when prescribing opioid agonist therapies for people living with HIV. Expert Review Of Clinical Pharmacology 2024, 17: 549-564. PMID: 38946101, PMCID: PMC11299801, DOI: 10.1080/17512433.2024.2375448.Peer-Reviewed Original ResearchMeSH KeywordsAnalgesics, OpioidAnti-HIV AgentsBuprenorphineDelayed-Action PreparationsDelivery of Health CareDrug InteractionsHealth Services AccessibilityHIV InfectionsHumansMethadoneNaltrexoneNarcotic AntagonistsOpiate Substitution TreatmentOpioid-Related DisordersPre-Exposure ProphylaxisUnited StatesConceptsOpioid agonist therapyOpioid use disorderAntiretroviral therapyAgonist therapyDiagnosed OUDOpioid use disorder managementUse disorderTreatment of opioid use disorderExtended-release naltrexonePotential drug interactionsOpioid use disorder treatmentPrescribed opioid agonist therapyLong-acting formulationPre-exposure prophylaxisOUD outcomesImprove HIV preventionIntersection of HIVOpioid antagonistHIV outcomesHIV epidemicOpioidHIVOpioid use disorder servicesPWHHIV preventionHIV and Substance Use Disorders
Lier A, Tarfa A, Shenoi S, Kuo I, Springer S. HIV and Substance Use Disorders. Infectious Disease Clinics Of North America 2024, 38: 599-611. PMID: 38960783, PMCID: PMC11410345, DOI: 10.1016/j.idc.2024.06.003.Peer-Reviewed Original ResearchHuman immunodeficiency virusSubstance use disordersEvidence-based public health effortsHuman immunodeficiency virus acquisitionHuman immunodeficiency virus incidenceRisk of HIV acquisitionUntreated substance use disordersPoor HIV outcomesAdherence to HIV antiretroviral therapyHIV antiretroviral therapyPublic health effortsInjection drug useAntiretroviral therapyHIV acquisitionImmunodeficiency virusHIV outcomesHealth effortsTreatment strategiesIncreased riskDrug useSubstance useDrugAmericanRiskPersons
2023
Poor HIV-Related Outcomes in Older Adults Newly Diagnosed With HIV: A 4-Year Retrospective Analysis From a Single Site in Asia
Wong H, Wong P, Bador M, Chong M, Shenoi S, Rozanova J, Omar S, Neelamegam M, Lee Y, Rajasuriar R. Poor HIV-Related Outcomes in Older Adults Newly Diagnosed With HIV: A 4-Year Retrospective Analysis From a Single Site in Asia. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2023, 93: 64-72. PMID: 36716735, DOI: 10.1097/qai.0000000000003169.Peer-Reviewed Original ResearchConceptsNew HIV diagnosesHIV diagnosisOlder adultsLate presentationYoung adultsRetrospective analysisJoin-point regression analysisAntiretroviral therapy initiationKaplan-Meier analysisNew HIV infectionsLog-rank testMalaya Medical CentreAnnual percent increaseMann-Whitney U testYoung key populationsResource-limited settingsAntiretroviral therapyTherapy initiationHIV infectionHIV testingHIV transmissionHeterosexual contactPoint regression analysisMedical CenterImmunological response
2021
Structural barriers to implementing recommended tuberculosis preventive treatment in primary care clinics in rural South Africa
Chandra DK, Moll AP, Altice FL, Didomizio E, Andrews L, Shenoi SV. Structural barriers to implementing recommended tuberculosis preventive treatment in primary care clinics in rural South Africa. Global Public Health 2021, 17: 555-568. PMID: 33650939, PMCID: PMC8410883, DOI: 10.1080/17441692.2021.1892793.Peer-Reviewed Original ResearchConceptsTuberculosis preventive treatmentPrimary healthcare clinicsTPT initiationWorld Health OrganizationAntiretroviral therapyPreventive treatmentRural South AfricaHIV/TB servicesBurden of HIVOnly independent correlatePrimary care clinicsClinic-level factorsPatient-level characteristicsPrimary care providersHealth Services frameworkEvidence-based strategiesQuality improvement strategiesTB servicesClinical factorsCare clinicsIndependent correlatesMedical recordsPromoting ActionCare providersHealthcare clinics
2020
989. Pre-exposure Prophylaxis (PrEP) Short-Term Retention Among Heavy Alcohol Users in Rural South Africa
Grammatico M, Choi K, Moll A, Shenoi S. 989. Pre-exposure Prophylaxis (PrEP) Short-Term Retention Among Heavy Alcohol Users in Rural South Africa. Open Forum Infectious Diseases 2020, 7: s523-s523. PMCID: PMC7776627, DOI: 10.1093/ofid/ofaa439.1175.Peer-Reviewed Original ResearchAlcohol use disorderHazardous alcohol usePrEP deliveryCommunity-based modelAntiretroviral therapyHIV testingAlcohol usersYoung menSexual partnersAlcohol usePre-exposure prophylaxisHazardous alcohol usersInconsistent condom useDifferentiated service deliveryOne-month followHome addressParticipant's home addressHeavy alcohol usersPrEP initiatorsPill countMedian ageHIV servicesEligible participantsHIV preventionPrevention services763. Correlates of Antiretroviral Therapy Initiation Among Newly Diagnosed Older People with HIV in Ukraine
Allen A, Zeziulin O, Rozanova J, Litz T, Zaviryukha I, Postnov O, Kiriazova T, Shenoi S. 763. Correlates of Antiretroviral Therapy Initiation Among Newly Diagnosed Older People with HIV in Ukraine. Open Forum Infectious Diseases 2020, 7: s427-s427. PMCID: PMC7777959, DOI: 10.1093/ofid/ofaa439.953.Peer-Reviewed Original ResearchTime of diagnosisART initiationAntiretroviral therapyAge-matched general populationMultivariable logistic regression modelOlder peopleLow CD4 countAntiretroviral therapy initiationHIV treatment outcomesMonths of diagnosisRetrospective chart reviewNew HIV diagnosesAdjusted odds ratioFirst clinical dataDispensing of medicationsImpact of ageLogistic regression modelsAdvanced diseaseCD4 countTherapy initiationChart reviewClinical characteristicsHIV diagnosisHIV patientsOpportunistic infections1644. “And the stick to fight TB is IPT”: Perspectives on TPT Implementation Among Senior Nurses in Rural South Africa
Grammatico M, Ahmed A, Grau L, Moll A, Shenoi S. 1644. “And the stick to fight TB is IPT”: Perspectives on TPT Implementation Among Senior Nurses in Rural South Africa. Open Forum Infectious Diseases 2020, 7: s811-s811. PMCID: PMC7777536, DOI: 10.1093/ofid/ofaa439.1824.Peer-Reviewed Original ResearchIsoniazid preventive therapyWorld Health OrganizationPreventative therapyMedian age 39 yearsSenior nursesTB preventative therapyPatient-level factorsPrimary health clinicsPrimary care clinicsAge 39 yearsHigh-volume clinicsHealth care experiencesResource-limited settingsBackground TuberculosisAntiretroviral therapyHigh tuberculosisChronic medicationsPill burdenPreventive therapyTB burdenHigh HIVCare clinicsConclusion NursesHIV prevalenceStandardized training program
2017
“It’s about my life”: facilitators of and barriers to isoniazid preventive therapy completion among people living with HIV in rural South Africa
Jacobson KB, Niccolai L, Mtungwa N, Moll AP, Shenoi SV. “It’s about my life”: facilitators of and barriers to isoniazid preventive therapy completion among people living with HIV in rural South Africa. AIDS Care 2017, 29: 936-942. PMID: 28147705, PMCID: PMC5545149, DOI: 10.1080/09540121.2017.1283390.Peer-Reviewed Original ResearchMeSH KeywordsAdultAIDS-Related Opportunistic InfectionsAmbulatory Care FacilitiesAntitubercular AgentsCounselingFemaleHealth Knowledge, Attitudes, PracticeHealth Services AccessibilityHIV InfectionsHumansIncidenceInterviews as TopicIsoniazidMalePatient ComplianceQualitative ResearchRural PopulationSocial StigmaSouth AfricaTrustTuberculosisConceptsIsoniazid preventive therapyIPT completionPreventive roleAbsence of symptomsHealth care workersKnowledge of TBHealth service deliveryResource-limited settingsHealth care systemRural KwaZulu-NatalAntiretroviral therapyHIV patientsHIV diagnosisPreventive therapyTherapy completionTB incidenceAppropriate counselingHealthcare workersIndividual patientsCare workersRural South AfricaHIVPatientsUnrelated conditionsIndividual semi-structured interviews
2016
Antiretroviral therapy initiation and adherence in rural South Africa: community health workers’ perspectives on barriers and facilitators
Loeliger KB, Niccolai LM, Mtungwa LN, Moll A, Shenoi SV. Antiretroviral therapy initiation and adherence in rural South Africa: community health workers’ perspectives on barriers and facilitators. AIDS Care 2016, 28: 982-993. PMID: 27043077, PMCID: PMC4917424, DOI: 10.1080/09540121.2016.1164292.Peer-Reviewed Original ResearchMeSH KeywordsAnti-HIV AgentsAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveBlack PeopleCommunity Health WorkersCounselingFocus GroupsHealth Services AccessibilityHIV InfectionsHumansInterviews as TopicLost to Follow-UpMaleMedication AdherenceQualitative ResearchRural PopulationSocial StigmaSocial SupportSocioeconomic FactorsSouth AfricaTruth DisclosureConceptsCommunity health workersAntiretroviral therapyART initiationHealth workersAntiretroviral therapy initiationInsufficient patient educationLong-term adherenceAcute infectious diseasesGlobal HIV/AIDS epidemicPublic health strategiesHealthcare servicesHIV/AIDS managementAlternative medicine (CAM) providersHIV/AIDS epidemicHIV/AIDSTherapy initiationInitial diagnosisLifelong therapyPrevent patientsAdherence ratesPatient counsellingPatient educationPatient dissatisfactionCHW rolesMedicine providers
2015
Community Health Worker Perspectives on Barriers to HIV+ Patients' Initiation of and Retention in Antiretroviral Therapy in Rural South Africa
Loeliger K, Niccolai L, Mntungwa N, Moll A, Friedland G, Shenoi S. Community Health Worker Perspectives on Barriers to HIV+ Patients' Initiation of and Retention in Antiretroviral Therapy in Rural South Africa. Open Forum Infectious Diseases 2015, 2: 405. DOI: 10.1093/ofid/ofv133.281.Peer-Reviewed Original Research
2013
Initial diagnosis of HIV/AIDS in a 56-year-old man with non-healing forearm lesion
Zapata HJ, Villanueva M, Shenoi S. Initial diagnosis of HIV/AIDS in a 56-year-old man with non-healing forearm lesion. BMJ Case Reports 2013, 2013: bcr2013201184. PMID: 24248316, PMCID: PMC3841407, DOI: 10.1136/bcr-2013-201184.Peer-Reviewed Case Reports and Technical NotesConceptsForearm lesionPatient underwent incisionHIV viral loadMonths of treatmentSignificant medical problemHIV/AIDSEmpiric antibioticsAntiretroviral therapyCD4 countUnderwent incisionInitial diagnosisViral loadStarry stainImmunohistochemistry testingCopies/Bacillary angiomatosisHispanic menMedical problemsLesionsBartonella quintanaCells/PatientsMenHIVAngiomatosis
2010
Extensively drug-resistant tuberculosis in children with human immunodeficiency virus in rural South Africa.
Thomas TA, Shenoi SV, Heysell SK, Eksteen FJ, Sunkari VB, Gandhi NR, Friedland G, Shah NS. Extensively drug-resistant tuberculosis in children with human immunodeficiency virus in rural South Africa. The International Journal Of Tuberculosis And Lung Disease 2010, 14: 1244-51. PMID: 20843414, PMCID: PMC3030274.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusXDR-TB diagnosisXDR-TBDrug-resistant tuberculosisPediatric wardImmunodeficiency virusRural South AfricaXDR-TB patientsXDR-TB treatmentActive antiretroviral therapySputum culture conversionNeuropsychiatric side effectsHospital pediatric wardInfection control policiesCulture conversionAntiretroviral therapyRadiographic improvementNosocomial transmissionOverlapping toxicitiesMicrobiologic dataHIV treatmentMedical recordsMicrobiologic diagnosisHIV therapyPrevious history