2023
Markerless head motion tracking and event-by-event correction in brain PET
Zeng T, Lu Y, Jiang W, Zheng J, Zhang J, Gravel P, Wan Q, Fontaine K, Mulnix T, Jiang Y, Yang Z, Revilla E, Naganawa M, Toyonaga T, Henry S, Zhang X, Cao T, Hu L, Carson R. Markerless head motion tracking and event-by-event correction in brain PET. Physics In Medicine And Biology 2023, 68: 245019. PMID: 37983915, PMCID: PMC10713921, DOI: 10.1088/1361-6560/ad0e37.Peer-Reviewed Original ResearchConceptsPoint source studyHead motion correctionSmaller residual displacementMotion correctionIterative closest point (ICP) registration algorithmHead motion trackingSpatial resolutionResidual displacementData-driven evaluation methodHigh spatial resolutionLow noiseMotion trackingStereovision cameraMotion tracking deviceStructured lightEvent correctionBrain positron emission tomography (PET) imagingTracking deviceReconstruction resultsHMT methodPoint cloudsNegative biasReference cloudUMTEvaluation method
2022
Neurotransmitter transporter occupancy following administration of centanafadine sustained-release tablets: A phase 1 study in healthy male adults
Matuskey D, Gallezot J, Nabulsi N, Henry S, Torres K, Dias M, Angarita G, Huang Y, Shoaf S, Carson R, Mehrotra S. Neurotransmitter transporter occupancy following administration of centanafadine sustained-release tablets: A phase 1 study in healthy male adults. Journal Of Psychopharmacology 2022, 37: 164-171. PMID: 36515395, PMCID: PMC9912308, DOI: 10.1177/02698811221140008.Peer-Reviewed Original ResearchAge, gender and body-mass-index relationships with in vivo CB1 receptor availability in healthy humans measured with [11C]OMAR PET
Radhakrishnan R, Worhunsky PD, Zheng MQ, Najafzadeh S, Gallezot JD, Planeta B, Henry S, Nabulsi N, Ranganathan M, Skosnik PD, Pittman B, Cyril D'Souza D, Carson RE, Huang Y, Potenza MN, Matuskey D. Age, gender and body-mass-index relationships with in vivo CB1 receptor availability in healthy humans measured with [11C]OMAR PET. NeuroImage 2022, 264: 119674. PMID: 36243269, DOI: 10.1016/j.neuroimage.2022.119674.Peer-Reviewed Original Research
2021
Assessment of test-retest reproducibility of [18F]SynVesT-1, a novel radiotracer for PET imaging of synaptic vesicle glycoprotein 2A
Li S, Naganawa M, Pracitto R, Najafzadeh S, Holden D, Henry S, Matuskey D, Emery PR, Cai Z, Ropchan J, Nabulsi N, Carson RE, Huang Y. Assessment of test-retest reproducibility of [18F]SynVesT-1, a novel radiotracer for PET imaging of synaptic vesicle glycoprotein 2A. European Journal Of Nuclear Medicine And Molecular Imaging 2021, 48: 1327-1338. PMID: 33416954, DOI: 10.1007/s00259-020-05149-3.Peer-Reviewed Original ResearchConceptsTest-retest reproducibilityTime-activity curvesBPND valuesNonhuman primatesAbsolute test-retest variabilitySynaptic vesicle glycoprotein 2AHigh brain uptakeNon-displaceable binding potentialExcellent test-retest reproducibilityGray matter areasHealthy human subjectsHigh uptakeTest-retest variabilityDynamic PET scanningTest-retest reliabilityBrain uptakeDistribution volume valuesCentrum semiovaleUrinary bladderOne-tissue compartment modelMaximum SUVPET scanningPET scansTracer uptakeBrain disorders
2020
First-in-Human Assessment of 11C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer
Naganawa M, Nabulsi N, Henry S, Matuskey D, Lin SF, Slieker L, Schwarz AJ, Kant N, Jesudason C, Ruley K, Navarro A, Gao H, Ropchan J, Labaree D, Carson RE, Huang Y. First-in-Human Assessment of 11C-LSN3172176, an M1 Muscarinic Acetylcholine Receptor PET Radiotracer. Journal Of Nuclear Medicine 2020, 62: 553-560. PMID: 32859711, PMCID: PMC8049371, DOI: 10.2967/jnumed.120.246967.Peer-Reviewed Original ResearchConceptsSimplified reference tissue modelM1 receptorsHealthy subjectsMuscarinic acetylcholine receptor subtype M1Distribution volumePET radiotracersAbsolute test-retest variabilityExcellent test-retest reproducibilityReference tissue model 2Total distribution volumeSuitable reference regionTest-retest reproducibilityTest-retest variabilityReference regionTest-retest protocolNondisplaceable distribution volumeReference tissue modelTest-retest studySubtypes M1Preclinical studiesRegional time-activity curvesAcetylcholine concentrationHuman studiesReceptor occupancyTime-activity curves
2019
Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers
Matuskey D, Dias M, Naganawa M, Pittman B, Henry S, Li S, Gao H, Ropchan J, Nabulsi N, Carson RE, Huang Y. Social status and demographic effects of the kappa opioid receptor: a PET imaging study with a novel agonist radiotracer in healthy volunteers. Neuropsychopharmacology 2019, 44: 1714-1719. PMID: 30928993, PMCID: PMC6785144, DOI: 10.1038/s41386-019-0379-7.Peer-Reviewed Original ResearchConceptsBody mass indexKappa-opioid receptorsPositron emission tomographyAgonist radiotracerKOR systemOpioid receptorsTime-activity curvesBarratt Simplified MeasureAnterior cingulate cortexArterial blood samplingMultilinear analysis-1 (MA1) methodPET imaging studiesKOR levelsMass indexPreclinical modelsFrontal cortexHealthy volunteersRegional time-activity curvesBlood samplingPET scansCingulate cortexImaging studiesEmission tomographyVentral striatumRegional volumesImaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain
Gallezot JD, Nabulsi N, Henry S, Pracitto R, Planeta B, Ropchan J, Lin SF, Labaree D, Kapinos M, Shirali A, Lara-Jaime T, Gao H, Matuskey D, Walzer M, Marek GJ, Bellaire S, Yuan N, Carson RE, Huang Y. Imaging the Enzyme 11β-Hydroxysteroid Dehydrogenase Type 1 with PET: Evaluation of the Novel Radiotracer 11C-AS2471907 in Human Brain. Journal Of Nuclear Medicine 2019, 60: 1140-1146. PMID: 30877174, DOI: 10.2967/jnumed.118.219766.Peer-Reviewed Original ResearchConceptsTest-retest variabilityNondisplaceable distribution volumeOccipital cortexEnzyme 11β-hydroxysteroid dehydrogenase type 1White matterDistribution volumeTreatment of depressionDehydrogenase type 1Large cortical regionsPosttraumatic stress disorderHuman brainAdditional scansIntraclass correlation coefficientAge-related cognitive functionBolus administrationFrontal cortexCaudate nucleusAdipose tissueTime-activity curvesNovel radiotracersGlucocorticoid levelsParietal cortexCortical regionsPattern of uptakeType 1
2015
Preclinical to Clinical Translation of CNS Transporter Occupancy of TD-9855, a Novel Norepinephrine and Serotonin Reuptake Inhibitor
Smith J, Patil D, Daniels O, Ding YS, Gallezot JD, Henry S, Kim K, Kshirsagar S, Martin W, Obedencio G, Stangeland E, Tsuruda P, Williams W, Carson R, Patil. Preclinical to Clinical Translation of CNS Transporter Occupancy of TD-9855, a Novel Norepinephrine and Serotonin Reuptake Inhibitor. The International Journal Of Neuropsychopharmacology 2015, 18: pyu027. PMID: 25522383, PMCID: PMC4368888, DOI: 10.1093/ijnp/pyu027.Peer-Reviewed Original ResearchMeSH KeywordsAdultAniline CompoundsAnimalsBlood Chemical AnalysisBrainHalf-LifeHumansMagnetic Resonance ImagingMaleModels, BiologicalMorpholinesNeurotransmitter Uptake InhibitorsNorepinephrine Plasma Membrane Transport ProteinsPhenyl EthersPiperidinesPositron-Emission TomographyRadiopharmaceuticalsRats, Sprague-DawleyReboxetineSerotonin Plasma Membrane Transport ProteinsSpinal CordSulfidesConceptsReuptake inhibitorsPositron emission tomographyNorepinephrine transporterSerotonin transporterSerotonin reuptake inhibitorsSingle oral doseUnique clinical profileMonoamine reuptake inhibitorsFuture clinical evaluationRat spinal cordNET occupancySERT occupancyClinical profileOral dosePlasma levelsTransporter profilesClinical evaluationSpinal cordTransporter occupancyCNS penetrationHealthy malesPharmacodynamic modelingNorepinephrineEmission tomographyPET studies
2012
Normative database of the serotonergic system in healthy subjects using multi-tracer PET
Savli M, Bauer A, Mitterhauser M, Ding Y, Hahn A, Kroll T, Neumeister A, Haeusler D, Ungersboeck J, Henry S, Isfahani S, Rattay F, Wadsak W, Kasper S, Lanzenberger R. Normative database of the serotonergic system in healthy subjects using multi-tracer PET. NeuroImage 2012, 63: 447-459. PMID: 22789740, DOI: 10.1016/j.neuroimage.2012.07.001.Peer-Reviewed Original ResearchConceptsReceptor subtypesSerotonergic systemPmol/Healthy subjectsNeuropsychiatric disordersPostsynaptic receptor subtypesDifferent receptor subtypesHealthy human subjectsPost-traumatic stress disorderAttention-deficit/hyperactivity disorderDeficit/hyperactivity disorderExcitatory receptorsObsessive-compulsive disorderPost-mortem dataSleep disturbancesBP valuesMost neuropsychiatric disordersPET scansMajor inhibitorySelective radioligandSuicidal behaviorPET studiesStress disorderBrodmann areasAnxiety disorders
2007
Serotonin transporter binding after recovery from eating disorders
Bailer U, Frank G, Henry S, Price J, Meltzer C, Becker C, Ziolko S, Mathis C, Wagner A, Barbarich-Marsteller N, Putnam K, Kaye W. Serotonin transporter binding after recovery from eating disorders. Psychopharmacology 2007, 195: 315-324. PMID: 17690869, DOI: 10.1007/s00213-007-0896-7.Peer-Reviewed Original ResearchConceptsAnorexia nervosaBulimia nervosaControl womenMethodsPositron emission tomographyHealthy control womenRestricting-type anorexia nervosaRationaleSeveral linesDorsal rapheDistribution volume valuesBP valuesFunction persistEmission tomographyDisorder subjectsResultsAfter correctionMultiple comparisonsTracer kinetic modelNervosaSpecific bindingAffective regulation
2005
Altered Brain Serotonin 5-HT1A Receptor Binding After Recovery From Anorexia Nervosa Measured by Positron Emission Tomography and [Carbonyl11C]WAY-100635
Bailer U, Frank G, Henry S, Price J, Meltzer C, Weissfeld L, Mathis C, Drevets W, Wagner A, Hoge J, Ziolko S, McConaha C, Kaye W. Altered Brain Serotonin 5-HT1A Receptor Binding After Recovery From Anorexia Nervosa Measured by Positron Emission Tomography and [Carbonyl11C]WAY-100635. JAMA Psychiatry 2005, 62: 1032-1041. PMID: 16143735, DOI: 10.1001/archpsyc.62.9.1032.Peer-Reviewed Original ResearchConceptsRestricting-type anorexia nervosaPositron emission tomographyAnorexia nervosaReceptor bindingEmission tomographyControl womenPathogenesis of ANDistribution volumeHealthy control womenEffects of malnutritionSerotonin neuronal activityLogan graphical methodPrefrontal cortical regionsSubgenual cingulate regionsBrain serotoninDorsal rapheReceptor antagonistSerotonergic functionBody of evidenceNeuronal activityCingulate regionsReceptor activityCortical regionsMeasures of anxietyWomenNormal Brain Tissue Volumes after Long-Term Recovery in Anorexia and Bulimia Nervosa
Wagner A, Greer P, Bailer U, Frank G, Henry S, Putnam K, Meltzer C, Ziolko S, Hoge J, McConaha C, Kaye W. Normal Brain Tissue Volumes after Long-Term Recovery in Anorexia and Bulimia Nervosa. Biological Psychiatry 2005, 59: 291-293. PMID: 16139807, DOI: 10.1016/j.biopsych.2005.06.014.Peer-Reviewed Original ResearchConceptsWhite matter volumeCerebrospinal fluid volumeControl womenBulimia nervosaLong-term recoveryMatter volumeNormal brain tissue volumeFluid volumeStructural brain abnormalitiesHealthy control womenBrain tissue volumesMagnetic resonance imagingBN subgroupsBrain abnormalitiesAnorexiaResonance imagingBinge/Type anorexiaTissue volumeNervosaWomenDisordersBrain imaging of serotonin after recovery from anorexia and bulimia nervosa
Kaye W, Bailer U, Frank G, Wagner A, Henry S. Brain imaging of serotonin after recovery from anorexia and bulimia nervosa. Physiology & Behavior 2005, 86: 15-17. PMID: 16102788, DOI: 10.1016/j.physbeh.2005.06.019.Peer-Reviewed Original ResearchConceptsBulimia nervosaPositron emission tomographyAnorexia nervosaReceptor functionModulation of feedingAge of onsetDegree of efficacyHomogenous presentationSerotonin pathwayGender distributionEmission tomographyBody image distortionBrain functionNew pharmacologyBrain imagingParietal regionsNervosaFood consumptionLines of evidenceSymptomsIllnessAlterationsPsychotherapy approachesPathwayFeeding behaviorNeurobiology of anorexia nervosa: Clinical implications of alterations of the function of serotonin and other neuronal systems
Kaye W, Frank G, Bailer U, Henry S. Neurobiology of anorexia nervosa: Clinical implications of alterations of the function of serotonin and other neuronal systems. International Journal Of Eating Disorders 2005, 37: s15-s19. PMID: 15852312, DOI: 10.1002/eat.20109.Peer-Reviewed Original Research
2004
Neuroimaging Studies in Eating Disorders
Frank G, Bailer U, Henry S, Wagner A, Kaye W. Neuroimaging Studies in Eating Disorders. CNS Spectrums 2004, 9: 539-549. PMID: 15208513, DOI: 10.1017/s1092852900009639.Peer-Reviewed Original ResearchConceptsMagnet resonance spectroscopyBulimia nervosaWhite matter volume lossBody image distortionRegional cerebral blood flowCerebral glucose metabolismCerebral blood flowSimilar brain regionsSerotonin metabolismBrain phospholipidsBlood flowGlucose metabolismBrain pathwaysAnorexiaBrain regionsIll stateAppetitive behaviorNeuroimaging studiesParietal regionsEating DisordersDisordersVolume lossSuch studiesMost studiesMetabolismAltered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness
Bailer U, Price J, Meltzer C, Mathis C, Frank G, Weissfeld L, McConaha C, Henry S, Brooks-Achenbach S, Barbarich N, Kaye W. Altered 5-HT2A Receptor Binding after Recovery from Bulimia-Type Anorexia Nervosa: Relationships to Harm Avoidance and Drive for Thinness. Neuropsychopharmacology 2004, 29: 1143-1155. PMID: 15054474, PMCID: PMC4301578, DOI: 10.1038/sj.npp.1300430.Peer-Reviewed Original ResearchConceptsControl womenAnorexia nervosaPositron emission tomographyBulimia nervosaBrain serotonin 2A (5-HT(2A)) receptorsMajor depressive disorder diagnosisDisturbances of appetiteLeft subgenual cingulateHealthy control womenDepressive disorder diagnosisEffects of malnutritionSerotonin 2A receptorRight occipital cortexLeft parietal cortexSubgenual cingulate regionsAN-BNReceptor antagonistNeuronal pathwaysSubgenual cingulateOccipital cortexHigh incidenceCingulate regionsParietal cortexCortical regionsEmission tomography