2021
EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis
Hidalgo D, Bejder J, Pop R, Gellatly K, Hwang Y, Maxwell Scalf S, Eastman AE, Chen JJ, Zhu LJ, Heuberger JAAC, Guo S, Koury MJ, Nordsborg NB, Socolovsky M. EpoR stimulates rapid cycling and larger red cells during mouse and human erythropoiesis. Nature Communications 2021, 12: 7334. PMID: 34921133, PMCID: PMC8683474, DOI: 10.1038/s41467-021-27562-4.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnimalsAntigens, CDBcl-X ProteinCD4 AntigensCell CycleCell DifferentiationCell NucleusCell SizeCell SurvivalCyclin-Dependent Kinase Inhibitor p27Embryo, MammalianErythroblastsErythrocytesErythropoiesisErythropoietinFemaleFetusHealthy VolunteersHumansIronLiverMaleMice, Inbred C57BLModels, BiologicalProtein Serine-Threonine KinasesReceptors, ErythropoietinReceptors, TransferrinReticulocytesSignal TransductionConceptsCell size regulationCell sizeSequential cell divisionsEpoR functionErythroblast survivalMouse erythroblastsCell divisionSize regulationHuman erythropoiesisErythropoietin receptorCell cycleEpoRHypoxic stressRed cell sizeHigh erythropoietinLarger red cellsWild-type miceCyclingErythroblastsRegulationHigher EPO levelsMiceRed cellsSurvivalErythropoiesis
2008
MicroRNA-Mediated Control of Cell Fate in Megakaryocyte-Erythrocyte Progenitors
Lu J, Guo S, Ebert BL, Zhang H, Peng X, Bosco J, Pretz J, Schlanger R, Wang JY, Mak RH, Dombkowski DM, Preffer FI, Scadden DT, Golub TR. MicroRNA-Mediated Control of Cell Fate in Megakaryocyte-Erythrocyte Progenitors. Developmental Cell 2008, 14: 843-853. PMID: 18539114, PMCID: PMC2688789, DOI: 10.1016/j.devcel.2008.03.012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, CD34Bone Marrow CellsCell DifferentiationCell LineageCells, CulturedErythroid CellsErythropoietinGene Expression RegulationGenes, ReporterHematopoietic Stem CellsHumansIntegrin beta3K562 CellsMegakaryocytesMiceMice, Inbred C57BLMicroRNAsModels, BiologicalPlatelet Membrane Glycoprotein IIbProto-Oncogene Proteins c-mybThrombopoietinConceptsMegakaryocyte-erythrocyte progenitorsLineage specificationTranscription factor MYBMiR-150Cell fateLineage fateRegenerative biologyErythroid cellsFunction experimentsMultipotent cellsMegakaryocytic lineageMiRNA expressionPrimary cellsCritical targetModel systemMicroRNAsProgenitorsFateRegulationCellsImportant participantsMYBLineagesMiRNAsBiology