2021
Variation in propofol induction doses administered to surgical patients over age 65
Schonberger RB, Bardia A, Dai F, Michel G, Yanez D, Curtis JP, Vaughn MT, Burg MM, Mathis M, Kheterpal S, Akhtar S, Shah N. Variation in propofol induction doses administered to surgical patients over age 65. Journal Of The American Geriatrics Society 2021, 69: 2195-2209. PMID: 33788251, PMCID: PMC8373684, DOI: 10.1111/jgs.17139.Peer-Reviewed Original ResearchConceptsPropofol induction dosesInduction dosesEndotracheal intubationGeneral anesthetic inductionPropofol induction dosePercent of patientsRetrospective observational studyLarge multicenter cohortSurgical patientsMulticenter cohortPropofol doseBolus doseGeneral anesthesiaInduction dosePropofol inductionPresent studyAnesthetic inductionDose administrationAdvanced agePatient variablesObservational studyProvider practicesAnaesthetic practiceClinical consequencesDosing decisions
2017
A Pilot Analysis of the Association Between Types of Monitored Anesthesia Care Drugs and Outcomes in Transfemoral Aortic Valve Replacement Performed Without General Anesthesia
Chen EY, Sukumar N, Dai F, Akhtar S, Schonberger RB. A Pilot Analysis of the Association Between Types of Monitored Anesthesia Care Drugs and Outcomes in Transfemoral Aortic Valve Replacement Performed Without General Anesthesia. Journal Of Cardiothoracic And Vascular Anesthesia 2017, 32: 666-671. PMID: 29277298, PMCID: PMC5766429, DOI: 10.1053/j.jvca.2017.07.009.Peer-Reviewed Original ResearchConceptsTransfemoral aortic valve replacementMonitored Anesthesia CareAortic valve replacementGeneral anesthesiaValve replacementAge incrementsMedication dose adjustmentUse of dexmedetomidineRetrospective observational studyType of sedationTertiary teaching hospitalHospital lengthPostoperative deliriumTAVR patientsDose adjustmentConscious sedationAnesthesia careCare drugsPossible differential effectsTeaching hospitalObservational studyAnesthetic agentsDose reductionDrug dosingPilot analysis
2016
A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients: Are We Overdosing Older Patients?
Akhtar S, Heng J, Dai F, Schonberger RB, Burg MM. A Retrospective Observational Study of Anesthetic Induction Dosing Practices in Female Elderly Surgical Patients: Are We Overdosing Older Patients? Drugs & Aging 2016, 33: 737-746. PMID: 27581549, DOI: 10.1007/s40266-016-0394-x.Peer-Reviewed Original ResearchConceptsDoses of fentanylOlder patientsFemale patientsInduction dosesGeneral anesthesiaObservational studyTertiary care academic hospitalElderly surgical patientsIncidence of hypotensionDose of propofolRetrospective observational studyOld female patientIntravenous anesthetic agentPost-induction hypotensionAge-associated differencesQuality improvement effortsResultsOlder patientsVasopressor therapyElderly patientsSurgical patientsYounger patientsBlood pressureHemodynamic outcomesASA-PSStudy designWe
2008
Preoperative β-blocker use: impact of national guidelines on clinical practice
Akhtar S, Assaad, Amin M, Holt NF, Barash PG, Silverman DG. Preoperative β-blocker use: impact of national guidelines on clinical practice. Journal Of Clinical Anesthesia 2008, 20: 122-128. PMID: 18410867, DOI: 10.1016/j.jclinane.2007.09.012.Peer-Reviewed Original ResearchConceptsBeta-blocker groupPost-guideline patientsPre-guideline groupVascular surgery patientsCoronary artery bypassTarget HRArtery bypassSurgery patientsPerioperative beta-blocker therapyPreoperative beta-blocker useTertiary care teaching hospitalMean HRElective vascular surgeryPost-guideline groupVascular surgery groupBeta-blocker therapyBeta-blocker useUnpaired t-testEligible patientsSurgery groupPreanesthetic evaluationVascular surgeryPresurgical patientsTeaching hospitalObservational study
2005
Preoperative β-blocker use: is titration to a heart rate of 60 beats per minute a consistently attainable goal?
Akhtar S, Amin M, Tantawy H, Senior A, Barash PG, Silverman DG. Preoperative β-blocker use: is titration to a heart rate of 60 beats per minute a consistently attainable goal? Journal Of Clinical Anesthesia 2005, 17: 191-197. PMID: 15896586, DOI: 10.1016/j.jclinane.2004.06.020.Peer-Reviewed Original ResearchConceptsPreinduction heart ratePerioperative beta-blocker useBeta-blocker useHeart rateCABG patientsEligible patientsSurgery patientsCoronary artery bypass graft surgeryArtery bypass graft surgeryTertiary care teaching hospitalBeta-blocker intoleranceCABG surgery patientsBeta-blocker therapyBypass graft surgeryVascular surgery patientsRetrospective observational studyUnpaired t-testBlocker groupGraft surgeryNoncardiac surgeryVascular patientsVascular surgeryTeaching hospitalObservational studyCurrent recommendations