2022
Nervous system consequences of COVID-19
Spudich S, Nath A. Nervous system consequences of COVID-19. Science 2022, 375: 267-269. PMID: 35050660, DOI: 10.1126/science.abm2052.Peer-Reviewed Original Research
2021
Neuropathogenesis of acute coronavirus disease 2019
Farhadian SF, Seilhean D, Spudich S. Neuropathogenesis of acute coronavirus disease 2019. Current Opinion In Neurology 2021, 34: 417-422. PMID: 33852526, DOI: 10.1097/wco.0000000000000944.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAcute SARS-CoV-2 infectionSARS-CoV-2 infectionNeurological complicationsSevere acute respiratory syndrome coronavirus 2Acute coronavirus disease 2019Acute respiratory syndrome coronavirus 2Potential long-term complicationsCOVID-19Respiratory syndrome coronavirus 2Direct viral invasionImmune-modulating interventionsCentral nervous system tissueLong-term complicationsSpecific immune responseSyndrome coronavirus 2Coronavirus disease 2019Nervous system tissueSubset of casesCoronavirus disease (COVID-19) pandemicParainfectious processViral meningoencephalitisNeurological symptomsVascular inflammationEndothelial activationCoronavirus 2
2020
Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019
Zubair AS, McAlpine LS, Gardin T, Farhadian S, Kuruvilla DE, Spudich S. Neuropathogenesis and Neurologic Manifestations of the Coronaviruses in the Age of Coronavirus Disease 2019. JAMA Neurology 2020, 77: 1018-1027. PMID: 32469387, PMCID: PMC7484225, DOI: 10.1001/jamaneurol.2020.2065.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAnimalsBetacoronavirusCoronavirus InfectionsCOVID-19HumansNervous System DiseasesPandemicsPneumonia, ViralSARS-CoV-2Severe Acute Respiratory SyndromeConceptsCentral nervous systemCoronavirus disease 2019Nervous systemDisease 2019Respiratory syndromeCOVID-19Severe acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2Long-term neurologic sequelaeRespiratory syndrome coronavirus 2Middle East respiratory syndromeSevere acute respiratory syndromeClinical neurological complicationsFurther neuropathological studiesBest treatment algorithmImproved clinical outcomesBlood-brain barrierImpairment of consciousnessSyndrome coronavirus 2Peripheral nervous systemAcute respiratory syndromeHuman coronavirus disease 2019Common neurologic complaintsSARS-CoV-2Neurologic sequelae
2018
Global Health Neurology: HIV/AIDS
Patel PB, Spudich SS. Global Health Neurology: HIV/AIDS. Seminars In Neurology 2018, 38: 238-246. PMID: 29791950, DOI: 10.1055/s-0038-1649334.Peer-Reviewed Original ResearchConceptsNeurologic complicationsLong-term HIVCombination antiretroviral therapyImpact of HIVResource-limited settingsHIV/AIDSAntiretroviral therapyOpportunistic infectionsCerebrovascular diseaseNeurocognitive disordersHIVMortality rateMajority of studiesComplicationsInternational studiesTherapyInfectionPrevalenceAIDSDiseaseIndividuals
2017
CROI 2017: Neurologic Complications of HIV Infection.
Spudich SS, Ances BM. CROI 2017: Neurologic Complications of HIV Infection. Topics In Antiviral Medicine 2017, 25: 69-76. PMID: 28598791, PMCID: PMC5677044.Peer-Reviewed Original ResearchConceptsEarly HIV infectionHIV infectionCentral nervous systemAntiretroviral therapyCNS HIV infectionPotential viral reservoirAntiretroviral regimensSuppressive therapyVirologic controlNeurologic complicationsBrain macrophagesOpportunistic infectionsViral reservoirCognitive screening testsMicroglial cellsChronic infectionRisk factorsNeurocognitive disordersT cellsChoroid plexusNervous systemCognitive impairmentNumerous cohortsScreening testLongitudinal evaluation
2016
HIV-Associated Neurologic Disorders and Central Nervous System Opportunistic Infections in HIV
Le LT, Spudich SS. HIV-Associated Neurologic Disorders and Central Nervous System Opportunistic Infections in HIV. Seminars In Neurology 2016, 36: 373-381. PMID: 27643907, DOI: 10.1055/s-0036-1585454.Peer-Reviewed Original ResearchMeSH KeywordsAIDS-Related Opportunistic InfectionsCD4-Positive T-LymphocytesHIV InfectionsHumansNervous System DiseasesOpportunistic InfectionsConceptsCombination antiretroviral therapyAsymptomatic neurocognitive impairmentPlasma viral loadViral loadMild neurocognitive disorderCerebral toxoplasmosisCryptococcal meningitisOpportunistic infectionsNeurocognitive disordersCentral nervous system opportunistic infectionsCNS immune reconstitution inflammatory syndromeDetectable plasma viral loadImmune reconstitution inflammatory syndromeCentral nervous system symptomsClassic opportunistic infectionsCSF viral loadProgressive neurologic symptomsReconstitution inflammatory syndromeT-cell countsProgressive multifocal leukoencephalopathyNervous system symptomsPresentation of infectionHigher mortality riskHigher CD4Immune recovery
2015
Neuropsychological Impairment in Acute HIV and the Effect of Immediate Antiretroviral Therapy
Kore I, Ananworanich J, Valcour V, Fletcher JL, Chalermchai T, Paul R, Reynolds J, Tipsuk S, Ubolyam S, Rattanamanee S, Jagodzinski L, Kim J, Spudich S. Neuropsychological Impairment in Acute HIV and the Effect of Immediate Antiretroviral Therapy. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2015, 70: 393-399. PMID: 26509933, PMCID: PMC4625393, DOI: 10.1097/qai.0000000000000746.Peer-Reviewed Original ResearchNeuropathogenesis of HIV: From Initial Neuroinvasion to HIV-Associated Neurocognitive Disorder (HAND)
Zayyad Z, Spudich S. Neuropathogenesis of HIV: From Initial Neuroinvasion to HIV-Associated Neurocognitive Disorder (HAND). Current HIV/AIDS Reports 2015, 12: 16-24. PMID: 25604237, PMCID: PMC4741099, DOI: 10.1007/s11904-014-0255-3.Peer-Reviewed Original ResearchConceptsHIV-Associated Neurocognitive DisordersCentral nervous systemCombination antiretroviral therapyNeurocognitive disordersTissue reservoirsInitial viral entryTargets of infectionCourse of infectionEarly-stage infectionHIV eradicationAntiretroviral therapyHIV neuropathogenesisSevere immunosuppressionClinical symptomsHIV replicationHIV epidemicLocal infectionCNS cellsPathological involvementPathogenetic processSevere formNervous systemNeurological diseasesAdvanced stageHIVCROI 2015: Neurologic Complications of HIV Infection.
Spudich SS, Ances BM. CROI 2015: Neurologic Complications of HIV Infection. Topics In Antiviral Medicine 2015, 23: 47-55. PMID: 25965311, PMCID: PMC6148901.Peer-Reviewed Original ResearchMeSH KeywordsCentral Nervous SystemHIV InfectionsHumansNervous System DiseasesNeuroimagingRisk FactorsConceptsCentral nervous systemModifiable risk factorsPathogenesis of HIVQuality of lifeBiomarkers of HANDResource-limited settingsNeurologic complicationsNeurologic presentationHIV infectionCNS reservoirsOpportunistic infectionsRisk factorsHIV epidemicCNS disordersCognitive dysfunctionNeurocognitive disordersHIVNervous systemInfectionDisordersCollaborative studyComplicationsDysfunctionPathogenesisDiagnosis
2014
Cerebrospinal Fluid (CSF) Neuronal Biomarkers across the Spectrum of HIV Infection: Hierarchy of Injury and Detection
Peterson J, Gisslen M, Zetterberg H, Fuchs D, Shacklett BL, Hagberg L, Yiannoutsos CT, Spudich SS, Price RW. Cerebrospinal Fluid (CSF) Neuronal Biomarkers across the Spectrum of HIV Infection: Hierarchy of Injury and Detection. PLOS ONE 2014, 9: e116081. PMID: 25541953, PMCID: PMC4277428, DOI: 10.1371/journal.pone.0116081.Peer-Reviewed Original ResearchConceptsNeurofilament light chain proteinT-tau levelsNeuronal biomarkersViral suppressionHIV infectionPrimary infectionCentral nervous system HIV infectionCSF t-tau levelsCSF Aβ peptidesHIV disease progressionAge-adjusted normsSoluble amyloid precursorHierarchy of sensitivityBlood CD4CD4 50HAD patientsHAD subjectsCD4 declineNeuronal injuryCross-sectional designProgressive injuryHIV progressionCSF biomarkersCSF concentrationsDisease progressionHIV Neurology
Spudich S, Meyer AC. HIV Neurology. Seminars In Neurology 2014, 34: 005-006. PMID: 24715482, DOI: 10.1055/s-0034-1372336.Peer-Reviewed Original Research
2013
Cerebrospinal Fluid and Neuroimaging Biomarker Abnormalities Suggest Early Neurological Injury in a Subset of Individuals During Primary HIV Infection
Peluso MJ, Meyerhoff DJ, Price RW, Peterson J, Lee E, Young AC, Walter R, Fuchs D, Brew BJ, Cinque P, Robertson K, Hagberg L, Zetterberg H, Gisslén M, Spudich S. Cerebrospinal Fluid and Neuroimaging Biomarker Abnormalities Suggest Early Neurological Injury in a Subset of Individuals During Primary HIV Infection. The Journal Of Infectious Diseases 2013, 207: 1703-1712. PMID: 23460748, PMCID: PMC3636785, DOI: 10.1093/infdis/jit088.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersCerebrospinal FluidCross-Sectional StudiesFemaleHIV InfectionsHumansMaleMiddle AgedNervous System DiseasesNeurofilament ProteinsNeuroimagingConceptsPrimary HIV infectionNeurofilament light chainHIV infectionAmyloid precursor proteinCerebrospinal fluidNeuronal injuryT-tauCSF/plasma albumin ratioPrimary human immunodeficiency virus (HIV) infectionCentral nervous system inflammationHuman immunodeficiency virus (HIV) infectionSoluble amyloid precursor proteinGamma-induced protein 10Primary infection groupNervous system inflammationImmunodeficiency virus infectionEarly neuronal injuryPlasma albumin ratioParietal gray matterGlutamate/creatineLight chainPrecursor proteinProton magnetic resonance spectroscopyFrontal white matterWhite blood cellsNeurologic complications of HIV infection: highlights from the 2013 Conference on Retroviruses and Opportunistic Infections.
Spudich SS, Ances BM. Neurologic complications of HIV infection: highlights from the 2013 Conference on Retroviruses and Opportunistic Infections. Topics In Antiviral Medicine 2013, 21: 100-8. PMID: 23981597, PMCID: PMC6148875.Peer-Reviewed Original ResearchConceptsHIV infectionOpportunistic infectionsNeurologic complicationsPathogenesis of HANDBiomarkers of HANDHIV encephalitisHIV diseaseHIV reservoirNeurologic presentationAntiretroviral adherenceHIV treatmentChronic diseasesHIV epidemicTreatment strategiesNeurocognitive disordersSevere formMild formInfectionCognitive functionComplicationsHIVPatientsDiseaseDisordersComplex conditions