2021
VZV myelitis with secondary HIV CSF escape
Weiss JJ, Spudich S, Barakat L. VZV myelitis with secondary HIV CSF escape. BMJ Case Reports 2021, 14: e241738. PMID: 34187795, PMCID: PMC8245447, DOI: 10.1136/bcr-2021-241738.Peer-Reviewed Case Reports and Technical NotesConceptsVaricella-zoster virusCSF escapeVZV myelitisSkin lesionsCerebrospinal fluidCSF HIV viral loadRight upper extremity weaknessCentral nervous system infectionSubsequent oral therapyUpper extremity weaknessHIV viral loadNervous system infectionVesicular skin lesionsCopies/mLDirect fluorescent antibody testingFluorescent antibody testingIntravenous acyclovirVZV PCRExtremity weaknessOral therapyRare complicationSystem infectionAtypical presentationImmunosuppressed patientsVZV infection
2013
Approach to Cerebrospinal Fluid (CSF) Biomarker Discovery and Evaluation in HIV Infection
Price RW, Peterson J, Fuchs D, Angel TE, Zetterberg H, Hagberg L, Spudich S, Smith RD, Jacobs JM, Brown JN, Gisslen M. Approach to Cerebrospinal Fluid (CSF) Biomarker Discovery and Evaluation in HIV Infection. Journal Of Neuroimmune Pharmacology 2013, 8: 1147-1158. PMID: 23943280, PMCID: PMC3889225, DOI: 10.1007/s11481-013-9491-3.Peer-Reviewed Original ResearchConceptsHIV infectionCentral nervous system infectionSystemic HIV infectionNervous system infectionCNS disease progressionCerebrospinal fluid biomarkersCross-sectional studyInteraction of HIVCSF biomarker studiesCNS infectionsDisease activitySystem infectionAntiretroviral treatmentClinical stagingNeural injuryCSF biomarkersNeurological consequencesFluid biomarkersDisease progressionMore accurate diagnosisNeuropsychological test performanceNovel biomarkersAccurate diagnosisBiomarker concentrationsInfection
2012
The cerebrospinal fluid proteome in HIV infection: change associated with disease severity
Angel TE, Jacobs JM, Spudich SS, Gritsenko MA, Fuchs D, Liegler T, Zetterberg H, Camp DG, Price RW, Smith RD. The cerebrospinal fluid proteome in HIV infection: change associated with disease severity. Clinical Proteomics 2012, 9: 3. PMID: 22433316, PMCID: PMC3353874, DOI: 10.1186/1559-0275-9-3.Peer-Reviewed Original ResearchCNS HIV infectionHIV infectionCerebrospinal fluidChronic asymptomatic infectionSystemic HIV infectionNervous system infectionAmyloid precursor proteinCSF proteomic analysisCerebrospinal fluid proteomeCSF neopterinAntiretroviral therapyDifferent time pointsSystem infectionNeural injuryImmune activationMotor dysfunctionAsymptomatic infectionClinical spectrumCSF biomarkersCSF analysisDisease progressionCSF samplesNeuronal plasticityDisease severityInfection
2008
Fever and Focal Cerebral Dysfunction
Spudich S. Fever and Focal Cerebral Dysfunction. 2008, 233-240. DOI: 10.1017/cbo9780511547454.041.Peer-Reviewed Original ResearchCerebral infectionIntracranial abscessNeurological findingsCerebral diseaseCentral nervous system infectionFocal cerebral dysfunctionFocal neurological findingsFocal neurological deficitsNervous system infectionPresence of feverVisual field cutCongenital heart diseaseHerpes simplex virusOne-sided weaknessCerebral complicationsFocal encephalitisNeurological deficitsSystem infectionGeneralized seizuresValvular diseaseCerebral dysfunctionImmunocompetent hostsMain diagnosisChronic infectionEar infections
2006
Defining and Evaluating HIV-Related Neurodegenerative Disease and Its Treatment Targets: A Combinatorial Approach to Use of Cerebrospinal Fluid Molecular Biomarkers
Gisslen M, Hagberg L, Rosengren L, Brew BJ, Cinque P, Spudich S, Price RW. Defining and Evaluating HIV-Related Neurodegenerative Disease and Its Treatment Targets: A Combinatorial Approach to Use of Cerebrospinal Fluid Molecular Biomarkers. Journal Of Neuroimmune Pharmacology 2006, 2: 112-119. PMID: 18040834, DOI: 10.1007/s11481-006-9035-1.Peer-Reviewed Original ResearchConceptsCNS HIV infectionAIDS dementia complexHIV infectionBrain injuryTreatment targetsCentral nervous system infectionNeurodegenerative diseasesSystemic HIV infectionComorbidities of patientsNervous system infectionAdjuvant treatment approachesCerebrospinal fluid markersRational trial designIntrathecal immunoactivationSystem infectionDementia complexAvailable treatmentsClinical trialsFluid markersTrial designTreatment approachesClinical practiceExperimental therapeuticsPatientsInfection