Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection
Hagberg L, Cinque P, Gisslen M, Brew BJ, Spudich S, Bestetti A, Price RW, Fuchs D. Cerebrospinal fluid neopterin: an informative biomarker of central nervous system immune activation in HIV-1 infection. AIDS Research And Therapy 2010, 7: 15. PMID: 20525234, PMCID: PMC2890504, DOI: 10.1186/1742-6405-7-15.Peer-Reviewed Original ResearchCSF HIV RNACSF neopterin concentrationsCSF neopterinCentral nervous systemIntrathecal immunoactivationCNS infectionsHIV RNANeopterin concentrationsImmune activationCerebrospinal fluidCentral nervous system immune activationNeurological diseasesBlood CD4 cell countCNS HIV infectionIntrathecal immune activationOngoing brain injuryOpportunistic CNS infectionsCD4 cell countCombination antiretroviral therapyCNS opportunistic infectionsMacrophage activation markersHIV-1 infectionSuppression of plasmaUntreated AIDS patientsAbsence of treatment