2021
Chapter 43 HIV and Other Retroviral Infections of the Nervous System
Peluso M, Spudich S. Chapter 43 HIV and Other Retroviral Infections of the Nervous System. 2021, 765-784. DOI: 10.1016/b978-0-12-819306-8.00043-5.Peer-Reviewed Original ResearchAntiretroviral therapyHIV infectionNeurologic manifestationsHuman immunodeficiency virus (HIV) infectionEra of ARTSuccessful systemic treatmentImmunodeficiency virus infectionEarly HIV infectionSystemic immune systemQuality of lifeAdvanced immunosuppressionAntiretroviral statusNeurologic complicationsNeurologic presentationSystemic treatmentVirus infectionCNS effectsCognitive disordersNervous systemImmune systemInfectionRetroviral infectionComplicationsHIVTherapy
2020
Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19
Farhadian S, Glick LR, Vogels CBF, Thomas J, Chiarella J, Casanovas-Massana A, Zhou J, Odio C, Vijayakumar P, Geng B, Fournier J, Bermejo S, Fauver JR, Alpert T, Wyllie AL, Turcotte C, Steinle M, Paczkowski P, Dela Cruz C, Wilen C, Ko AI, MacKay S, Grubaugh ND, Spudich S, Barakat LA. Acute encephalopathy with elevated CSF inflammatory markers as the initial presentation of COVID-19. BMC Neurology 2020, 20: 248. PMID: 32552792, PMCID: PMC7301053, DOI: 10.1186/s12883-020-01812-2.Peer-Reviewed Original ResearchConceptsInitial presentationCentral nervous system inflammationSARS-CoV-2 infectionCSF inflammatory markersNervous system inflammationCerebrospinal fluid (CSF) cytokinesSeizure-like activityCOVID-19 infectionVirus SARS-CoV-2COVID-19SARS-CoV-2BackgroundCOVID-19Inflammatory markersNeurologic complicationsSystem inflammationImmunocompromised womanNeurologic manifestationsNeurologic symptomsViral neuroinvasionCase presentationWeInfected patientsMental statusRespiratory pathogensConclusionOur findingsInflammation
2018
Global Health Neurology: HIV/AIDS
Patel PB, Spudich SS. Global Health Neurology: HIV/AIDS. Seminars In Neurology 2018, 38: 238-246. PMID: 29791950, DOI: 10.1055/s-0038-1649334.Peer-Reviewed Original ResearchConceptsNeurologic complicationsLong-term HIVCombination antiretroviral therapyImpact of HIVResource-limited settingsHIV/AIDSAntiretroviral therapyOpportunistic infectionsCerebrovascular diseaseNeurocognitive disordersHIVMortality rateMajority of studiesComplicationsInternational studiesTherapyInfectionPrevalenceAIDSDiseaseIndividuals
2017
CROI 2017: Neurologic Complications of HIV Infection.
Spudich SS, Ances BM. CROI 2017: Neurologic Complications of HIV Infection. Topics In Antiviral Medicine 2017, 25: 69-76. PMID: 28598791, PMCID: PMC5677044.Peer-Reviewed Original ResearchConceptsEarly HIV infectionHIV infectionCentral nervous systemAntiretroviral therapyCNS HIV infectionPotential viral reservoirAntiretroviral regimensSuppressive therapyVirologic controlNeurologic complicationsBrain macrophagesOpportunistic infectionsViral reservoirCognitive screening testsMicroglial cellsChronic infectionRisk factorsNeurocognitive disordersT cellsChoroid plexusNervous systemCognitive impairmentNumerous cohortsScreening testLongitudinal evaluation
2016
CROI 2016: Neurologic Complications of HIV Infection.
Spudich SS, Ances BM. CROI 2016: Neurologic Complications of HIV Infection. Topics In Antiviral Medicine 2016, 24: 29-37. PMID: 27398860, PMCID: PMC6148921.Peer-Reviewed Original ResearchConceptsCentral nervous systemHIV infectionTraditional vascular risk factorsPrognosis of handSuppressive antiretroviral treatmentVascular risk factorsStandard antiretroviral therapyPotential adjunctive therapyLarge epidemiologic studiesMacrophage lineage cellsRecreational drug useHIV escapeHIV measuresAntiretroviral therapyHepatic dysfunctionNeurologic complicationsAdjunctive therapyAntiretroviral treatmentSystemic compartmentOpportunistic infectionsHIV replicationFemale sexPotential complicationsRisk factorsNeurocognitive disorders
2015
CROI 2015: Neurologic Complications of HIV Infection.
Spudich SS, Ances BM. CROI 2015: Neurologic Complications of HIV Infection. Topics In Antiviral Medicine 2015, 23: 47-55. PMID: 25965311, PMCID: PMC6148901.Peer-Reviewed Original ResearchConceptsCentral nervous systemModifiable risk factorsPathogenesis of HIVQuality of lifeBiomarkers of HANDResource-limited settingsNeurologic complicationsNeurologic presentationHIV infectionCNS reservoirsOpportunistic infectionsRisk factorsHIV epidemicCNS disordersCognitive dysfunctionNeurocognitive disordersHIVNervous systemInfectionDisordersCollaborative studyComplicationsDysfunctionPathogenesisDiagnosis
2014
CROI 2014: Neurologic complications of HIV infection.
Spudich SS. CROI 2014: Neurologic complications of HIV infection. Topics In Antiviral Medicine 2014, 22: 594-601. PMID: 24901885, PMCID: PMC6148910.Peer-Reviewed Original ResearchConceptsCentral nervous systemCerebrospinal fluidHIV infectionCNS immune activationEarly HIV diagnosisHost genetic determinantsNeurologic complicationsNeurologic morbidityHIV diagnosisOpportunistic infectionsPersistent abnormalitiesHIV replicationImmune activationCNS dysfunctionCSF biomarkersNeurocognitive disordersHIV detectionNervous systemCognitive impairmentHIVSalutary effectsMild formEnd pointInfectionPotential mediatorsChapter 44 HIV and other Retroviral Infections of the Nervous System
Peluso M, Spudich S. Chapter 44 HIV and other Retroviral Infections of the Nervous System. 2014, 885-909. DOI: 10.1016/b978-0-12-407710-2.00044-8.Peer-Reviewed Original ResearchCombination antiretroviral therapyHIV infectionNeurologic manifestationsEra of cARTHuman immunodeficiency virus (HIV) infectionSuccessful systemic treatmentImmunodeficiency virus infectionEarly HIV infectionSystemic immune systemQuality of lifeAdvanced immunosuppressionAntiretroviral statusAntiretroviral therapyNeurologic complicationsNeurologic presentationSystemic treatmentVirus infectionCNS effectsCognitive disordersNervous systemImmune systemInfectionRetroviral infectionComplicationsHIV
2013
Neurologic complications of HIV infection: highlights from the 2013 Conference on Retroviruses and Opportunistic Infections.
Spudich SS, Ances BM. Neurologic complications of HIV infection: highlights from the 2013 Conference on Retroviruses and Opportunistic Infections. Topics In Antiviral Medicine 2013, 21: 100-8. PMID: 23981597, PMCID: PMC6148875.Peer-Reviewed Original ResearchConceptsHIV infectionOpportunistic infectionsNeurologic complicationsPathogenesis of HANDBiomarkers of HANDHIV encephalitisHIV diseaseHIV reservoirNeurologic presentationAntiretroviral adherenceHIV treatmentChronic diseasesHIV epidemicTreatment strategiesNeurocognitive disordersSevere formMild formInfectionCognitive functionComplicationsHIVPatientsDiseaseDisordersComplex conditions
2012
Neurologic complications of HIV infection.
Spudich SS, Ances BM. Neurologic complications of HIV infection. Topics In Antiviral Medicine 2012, 20: 41-7. PMID: 22710906, PMCID: PMC6148861.Peer-Reviewed Original ResearchConceptsCentral nervous systemHIV infectionNervous systemBrain microglial activationWarrants further studyAntiretroviral therapyNeurologic complicationsMicroglial activationNeurologic impairmentOpportunistic infectionsClinical studiesEarly initiationNeurocognitive disordersHIV-1Neuropsychological testingHIVNormal agingOngoing abnormalitiesInfectionFurther studiesTherapyComplicationsNeuropathogenesisPoster presentationsAbnormalities