2022
Infection and inflammation: New perspectives on Alzheimer's disease
Whitson HE, Colton C, Khoury J, Gate D, Goate A, Heneka MT, Kaddurah-Daouk R, Klein RS, Shinohara ML, Sisodia S, Spudich SS, Stevens B, Tanzi R, Ting JP, Garden G, members S, Aiello A, Chiba-Falek O, Heitman J, Johnson K, Luftig M, Moseman A, Rawls J, Shinohara M, Swanstrom R, Terrando N. Infection and inflammation: New perspectives on Alzheimer's disease. Brain Behavior & Immunity - Health 2022, 22: 100462. PMID: 36118272, PMCID: PMC9475126, DOI: 10.1016/j.bbih.2022.100462.Peer-Reviewed Original ResearchDisease Research CenterAlzheimer's diseaseAD pathogenesisSelf-reactive T cellsDisease pathologyCOVID-19 patientsAlzheimer's Disease Research CenterAlzheimer's disease pathologyNeurologic symptomsInflammatory cellsT cellsMouse modelCurrent evidenceHuman immunityAlois AlzheimerMetabolic alterationsCommensal microbesFungal infectionsInfectionDiseasePotential involvementInflammationPathogenesisFunctional stateNeuroinflammation
2018
Global Health Neurology: HIV/AIDS
Patel PB, Spudich SS. Global Health Neurology: HIV/AIDS. Seminars In Neurology 2018, 38: 238-246. PMID: 29791950, DOI: 10.1055/s-0038-1649334.Peer-Reviewed Original ResearchConceptsNeurologic complicationsLong-term HIVCombination antiretroviral therapyImpact of HIVResource-limited settingsHIV/AIDSAntiretroviral therapyOpportunistic infectionsCerebrovascular diseaseNeurocognitive disordersHIVMortality rateMajority of studiesComplicationsInternational studiesTherapyInfectionPrevalenceAIDSDiseaseIndividuals
2014
Treatment of HIV in the CNS: Effects of Antiretroviral Therapy and the Promise of Non-Antiretroviral Therapeutics
Peluso MJ, Spudich S. Treatment of HIV in the CNS: Effects of Antiretroviral Therapy and the Promise of Non-Antiretroviral Therapeutics. Current HIV/AIDS Reports 2014, 11: 353-362. PMID: 25063356, DOI: 10.1007/s11904-014-0223-y.Peer-Reviewed Original ResearchConceptsCentral nervous systemAntiretroviral therapyNew neurologic abnormalitiesTrajectory of HIVAIDS dementia complexSpectrum of HIVTreatment of HIVPersistent handViral suppressionNeurologic manifestationsAsymptomatic diseaseHIV infectionNeurologic abnormalitiesNeurocognitive disordersNeurologic diseaseNeurocognitive dysfunctionTherapeutic modalitiesNervous systemHIVSevere impairmentTherapyDiseasePatientsDysfunctionPathophysiology
2013
Neurologic complications of HIV infection: highlights from the 2013 Conference on Retroviruses and Opportunistic Infections.
Spudich SS, Ances BM. Neurologic complications of HIV infection: highlights from the 2013 Conference on Retroviruses and Opportunistic Infections. Topics In Antiviral Medicine 2013, 21: 100-8. PMID: 23981597, PMCID: PMC6148875.Peer-Reviewed Original ResearchConceptsHIV infectionOpportunistic infectionsNeurologic complicationsPathogenesis of HANDBiomarkers of HANDHIV encephalitisHIV diseaseHIV reservoirNeurologic presentationAntiretroviral adherenceHIV treatmentChronic diseasesHIV epidemicTreatment strategiesNeurocognitive disordersSevere formMild formInfectionCognitive functionComplicationsHIVPatientsDiseaseDisordersComplex conditions
2012
Depression and Mood States and Correlations with Biomarkers of Central Nervous System Disease in Primary-HIV Infection (P01.262)
Gold J, Peterson J, Lee E, Fuchs D, Price R, Yiannoutsos C, Robertson K, Spudich S. Depression and Mood States and Correlations with Biomarkers of Central Nervous System Disease in Primary-HIV Infection (P01.262). Neurology 2012, 78: p01.262-p01.262. DOI: 10.1212/wnl.78.1_meetingabstracts.p01.262.Peer-Reviewed Original Research
2008
HIV/AIDS of the Central Nervous System
Spudich S. HIV/AIDS of the Central Nervous System. 2008, 430-445. DOI: 10.1016/b978-012373960-5.00019-8.Peer-Reviewed Original ResearchNeurological disordersMajority of HIVPublic health burdenDisease-specific therapiesCentral nervous systemHIV/AIDSAntiretroviral treatmentOpportunistic infectionsPeripheral nervesVascular disordersSpinal cordHealth burdenHIV-1Nervous systemImportant causeNeurological diseasesNutritional diseasesDisordersHIVInfectionAIDSDiseaseDisease epidemicsMorbidityNerve
1999
Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease
Fatkin D, MacRae C, Sasaki T, Wolff M, Porcu M, Frenneaux M, Atherton J, Vidaillet H, Spudich S, De Girolami U, Seidman JG, Muntoni F, Müehle G, Johnson W, McDonough B, Seidman C. Missense Mutations in the Rod Domain of the Lamin A/C Gene as Causes of Dilated Cardiomyopathy and Conduction-System Disease. New England Journal Of Medicine 1999, 341: 1715-1724. PMID: 10580070, DOI: 10.1056/nejm199912023412302.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAmino Acid SequenceArrhythmias, CardiacCardiomyopathy, DilatedChromosome MappingChromosomes, Human, Pair 1FemaleGenes, DominantGenotypeHumansLamin Type ALaminsMaleMiddle AgedMolecular Sequence DataMuscular Dystrophy, Emery-DreifussMutation, MissenseNuclear ProteinsPedigreeProtein IsoformsSequence Analysis, DNAConceptsConduction system diseaseLamin A/C geneJoint contracturesCardiac conductionEmery-Dreifuss muscular dystrophySerum creatine kinase levelsProgressive conduction system diseaseMuscular dystrophyFamily membersChildhood-onset diseaseCreatine kinase levelsPercent of casesMissense mutationsHeart failureKinase levelsSudden deathNovel missense mutationSkeletal myopathyDiseaseGenetic causeC geneNuclear envelope protein lamin AIntermediate filament proteinsGene defectsGenetic defects
1995
Complete Penetrance of Creutzfeldt-Jakob Disease in Libyan Jews Carrying the E200K Mutation in the Prion Protein Gene
Spudich S, Mastrianni J, Wrensch M, Gabizon R, Meiner Z, Kahana I, Rosenmann H, Kahana E, Prusiner S. Complete Penetrance of Creutzfeldt-Jakob Disease in Libyan Jews Carrying the E200K Mutation in the Prion Protein Gene. Molecular Medicine 1995, 1: 607-613. PMID: 8529127, PMCID: PMC2229975, DOI: 10.1007/bf03401601.Peer-Reviewed Original Research