2023
Biotypes of Central Nervous System Complications in People With Human Immunodeficiency Virus: Virology, Immunology, and Neuropathology
Joseph S, Gianella S, Burdo T, Cinque P, Gisslen M, Letendre S, Nath A, Morgello S, Ndhlovu L, Spudich S. Biotypes of Central Nervous System Complications in People With Human Immunodeficiency Virus: Virology, Immunology, and Neuropathology. The Journal Of Infectious Diseases 2023, 227: s3-s15. PMID: 36930640, PMCID: PMC10022721, DOI: 10.1093/infdis/jiac370.Peer-Reviewed Original ResearchConceptsHuman immunodeficiency virusCentral nervous system complicationsNervous system complicationsAntiretroviral therapySystem complicationsImmunodeficiency virusMental health disordersMild cognitive impairmentCNS complicationsMultifactorial pathogenesisViral suppressionHeterogeneity of mechanismsCNS diseaseNeuropathological dataEffective treatmentHealth disordersCognitive impairmentPreventive interventionsComplicationsImmunologyVirusWorking GroupVirologyNeuroHIVNeuropathology
2021
Chapter 43 HIV and Other Retroviral Infections of the Nervous System
Peluso M, Spudich S. Chapter 43 HIV and Other Retroviral Infections of the Nervous System. 2021, 765-784. DOI: 10.1016/b978-0-12-819306-8.00043-5.Peer-Reviewed Original ResearchAntiretroviral therapyHIV infectionNeurologic manifestationsHuman immunodeficiency virus (HIV) infectionEra of ARTSuccessful systemic treatmentImmunodeficiency virus infectionEarly HIV infectionSystemic immune systemQuality of lifeAdvanced immunosuppressionAntiretroviral statusNeurologic complicationsNeurologic presentationSystemic treatmentVirus infectionCNS effectsCognitive disordersNervous systemImmune systemInfectionRetroviral infectionComplicationsHIVTherapy
2018
Global Health Neurology: HIV/AIDS
Patel PB, Spudich SS. Global Health Neurology: HIV/AIDS. Seminars In Neurology 2018, 38: 238-246. PMID: 29791950, DOI: 10.1055/s-0038-1649334.Peer-Reviewed Original ResearchConceptsNeurologic complicationsLong-term HIVCombination antiretroviral therapyImpact of HIVResource-limited settingsHIV/AIDSAntiretroviral therapyOpportunistic infectionsCerebrovascular diseaseNeurocognitive disordersHIVMortality rateMajority of studiesComplicationsInternational studiesTherapyInfectionPrevalenceAIDSDiseaseIndividuals
2015
Neurosyphilis and the impact of HIV infection
Ho EL, Spudich SS. Neurosyphilis and the impact of HIV infection. Sexual Health 2015, 12: 148-154. PMID: 25890619, DOI: 10.1071/sh14195.Peer-Reviewed Original ResearchCROI 2015: Neurologic Complications of HIV Infection.
Spudich SS, Ances BM. CROI 2015: Neurologic Complications of HIV Infection. Topics In Antiviral Medicine 2015, 23: 47-55. PMID: 25965311, PMCID: PMC6148901.Peer-Reviewed Original ResearchConceptsCentral nervous systemModifiable risk factorsPathogenesis of HIVQuality of lifeBiomarkers of HANDResource-limited settingsNeurologic complicationsNeurologic presentationHIV infectionCNS reservoirsOpportunistic infectionsRisk factorsHIV epidemicCNS disordersCognitive dysfunctionNeurocognitive disordersHIVNervous systemInfectionDisordersCollaborative studyComplicationsDysfunctionPathogenesisDiagnosis
2014
Chapter 44 HIV and other Retroviral Infections of the Nervous System
Peluso M, Spudich S. Chapter 44 HIV and other Retroviral Infections of the Nervous System. 2014, 885-909. DOI: 10.1016/b978-0-12-407710-2.00044-8.Peer-Reviewed Original ResearchCombination antiretroviral therapyHIV infectionNeurologic manifestationsEra of cARTHuman immunodeficiency virus (HIV) infectionSuccessful systemic treatmentImmunodeficiency virus infectionEarly HIV infectionSystemic immune systemQuality of lifeAdvanced immunosuppressionAntiretroviral statusAntiretroviral therapyNeurologic complicationsNeurologic presentationSystemic treatmentVirus infectionCNS effectsCognitive disordersNervous systemImmune systemInfectionRetroviral infectionComplicationsHIV
2013
Neurologic complications of HIV infection: highlights from the 2013 Conference on Retroviruses and Opportunistic Infections.
Spudich SS, Ances BM. Neurologic complications of HIV infection: highlights from the 2013 Conference on Retroviruses and Opportunistic Infections. Topics In Antiviral Medicine 2013, 21: 100-8. PMID: 23981597, PMCID: PMC6148875.Peer-Reviewed Original ResearchConceptsHIV infectionOpportunistic infectionsNeurologic complicationsPathogenesis of HANDBiomarkers of HANDHIV encephalitisHIV diseaseHIV reservoirNeurologic presentationAntiretroviral adherenceHIV treatmentChronic diseasesHIV epidemicTreatment strategiesNeurocognitive disordersSevere formMild formInfectionCognitive functionComplicationsHIVPatientsDiseaseDisordersComplex conditions
2012
Neurologic complications of HIV infection.
Spudich SS, Ances BM. Neurologic complications of HIV infection. Topics In Antiviral Medicine 2012, 20: 41-7. PMID: 22710906, PMCID: PMC6148861.Peer-Reviewed Original ResearchConceptsCentral nervous systemHIV infectionNervous systemBrain microglial activationWarrants further studyAntiretroviral therapyNeurologic complicationsMicroglial activationNeurologic impairmentOpportunistic infectionsClinical studiesEarly initiationNeurocognitive disordersHIV-1Neuropsychological testingHIVNormal agingOngoing abnormalitiesInfectionFurther studiesTherapyComplicationsNeuropathogenesisPoster presentationsAbnormalities