2024
New approaches for understanding the potential role of microbes in Alzheimer's disease
Whitson H, Banks W, Diaz M, Frost B, Kellis M, Lathe R, Schmader K, Spudich S, Tanzi R, Garden G. New approaches for understanding the potential role of microbes in Alzheimer's disease. Brain Behavior & Immunity - Health 2024, 36: 100743. PMID: 38435720, PMCID: PMC10906156, DOI: 10.1016/j.bbih.2024.100743.Peer-Reviewed Original ResearchAlzheimer's diseaseAD pathologyAntimicrobial protection hypothesisInfluence AD pathologyGene-environment interactionsModel organismsMicrobial organismsMicrobesPotential roleAmyloid accumulationProtection hypothesisAlzheimerImmune cell activationReview new evidencePathological processesCell activationComplex pathological processAmyloidGermOrganizationAlzheimer's Disease Research Center
2022
Infection and inflammation: New perspectives on Alzheimer's disease
Whitson HE, Colton C, Khoury J, Gate D, Goate A, Heneka MT, Kaddurah-Daouk R, Klein RS, Shinohara ML, Sisodia S, Spudich SS, Stevens B, Tanzi R, Ting JP, Garden G, members S, Aiello A, Chiba-Falek O, Heitman J, Johnson K, Luftig M, Moseman A, Rawls J, Shinohara M, Swanstrom R, Terrando N. Infection and inflammation: New perspectives on Alzheimer's disease. Brain Behavior & Immunity - Health 2022, 22: 100462. PMID: 36118272, PMCID: PMC9475126, DOI: 10.1016/j.bbih.2022.100462.Peer-Reviewed Original ResearchDisease Research CenterAlzheimer's diseaseAD pathogenesisSelf-reactive T cellsDisease pathologyCOVID-19 patientsAlzheimer's Disease Research CenterAlzheimer's disease pathologyNeurologic symptomsInflammatory cellsT cellsMouse modelCurrent evidenceHuman immunityAlois AlzheimerMetabolic alterationsCommensal microbesFungal infectionsInfectionDiseasePotential involvementInflammationPathogenesisFunctional stateNeuroinflammation
2020
Coronavirus disease 2019 and neurodegenerative disease: what will the future bring?
McAlpine LS, Fesharaki-Zadeh A, Spudich S. Coronavirus disease 2019 and neurodegenerative disease: what will the future bring? Current Opinion In Psychiatry 2020, 34: 177-185. PMID: 33395100, PMCID: PMC7924921, DOI: 10.1097/yco.0000000000000688.Peer-Reviewed Original ResearchConceptsCoronavirus disease 2019Multiple sclerosisParkinson's diseaseNeurodegenerative diseasesAlzheimer's diseaseDisease 2019High riskCOVID-19Heart/lung diseaseHigh-risk comorbid conditionsHospitalized COVID-19 patientsAltered mental statusCOVID-19 patientsMS patientsSuch patientsComorbid conditionsNeurological symptomsPoor outcomeLung diseaseMental statusAdvanced ageSevere diseasePatientsBetter outcomesViral infection
2019
Cerebrospinal Fluid Concentrations of the Synaptic Marker Neurogranin in Neuro-HIV and Other Neurological Disorders
Yilmaz A, Fuchs D, Price RW, Spudich S, Blennow K, Zetterberg H, Gisslén M. Cerebrospinal Fluid Concentrations of the Synaptic Marker Neurogranin in Neuro-HIV and Other Neurological Disorders. Current HIV/AIDS Reports 2019, 16: 76-81. PMID: 30649659, PMCID: PMC6420419, DOI: 10.1007/s11904-019-00420-1.Peer-Reviewed Original ResearchConceptsCSF neurograninCerebrospinal fluidProinflammatory cytokines IL-1βGroup of HIVLewy body dementiaCerebrospinal fluid concentrationsCytokines IL-1βLevels of neurograninNeurogranin concentrationsNeuro-HIVHIV neuropathogenesisSynaptic injuryHIV infectionIL-1βNeurocognitive disordersFrontal cortexParkinson's diseaseUninfected controlsReviewThe aimAlzheimer's diseaseNeurological disordersFrontotemporal dementiaNeurodegenerative disordersFluid concentrationsHIV
2009
Amyloid and tau cerebrospinal fluid biomarkers in HIV infection
Gisslén M, Krut J, Andreasson U, Blennow K, Cinque P, Brew BJ, Spudich S, Hagberg L, Rosengren L, Price RW, Zetterberg H. Amyloid and tau cerebrospinal fluid biomarkers in HIV infection. BMC Neurology 2009, 9: 63. PMID: 20028512, PMCID: PMC2807422, DOI: 10.1186/1471-2377-9-63.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAIDS Dementia ComplexAIDS-Related Opportunistic InfectionsAlzheimer DiseaseAmyloid beta-PeptidesAmyloid beta-Protein PrecursorAnalysis of VarianceBiomarkersCross-Sectional StudiesFemaleHIV InfectionsHIV-1HumansMaleMiddle AgedPeptide FragmentsPrincipal Component AnalysisTau ProteinsConceptsAIDS dementia complexCerebrospinal fluid biomarkersOpportunistic infectionsADC patientsAlzheimer's diseaseHIV infectionP-tauDisease patientsFluid biomarkersCentral nervous system opportunistic infectionsSoluble amyloid precursor protein alphaLower CSF Aβ1-42CSF t-tau levelsCNS immune activationCNS opportunistic infectionsCSF p-tauCSF t-tauT-tau levelsCross-sectional studyCSF Aβ1-42Alzheimer's disease patientsUninfected subjectsInfection patientsNeural injuryNeurological symptoms