2023
Genomic evidence of sex chromosome aneuploidy and infection-associated genotypes in the tsetse fly Glossina fuscipes, the major vector of African trypanosomiasis in Uganda
Saarman N, Son J, Zhao H, Cosme L, Kong Y, Li M, Wang S, Weiss B, Echodu R, Opiro R, Aksoy S, Caccone A. Genomic evidence of sex chromosome aneuploidy and infection-associated genotypes in the tsetse fly Glossina fuscipes, the major vector of African trypanosomiasis in Uganda. Infection Genetics And Evolution 2023, 114: 105501. PMID: 37709241, PMCID: PMC10593118, DOI: 10.1016/j.meegid.2023.105501.Peer-Reviewed Original ResearchConceptsGenome-wide association analysisNovel vector control strategiesAnimal African trypanosomiasisSex chromosome aneuploidyNatural populationsGenome assemblySex chromosomesGenomic regionsGenomic evidenceGenetic variationBp upstreamAutosomal SNPsSeq dataTrypanosome infectionTrypanosome parasitesAssociation analysisMolecular pathwaysAssembly metricsLinkage disequilibriumLecithin-cholesterol acyltransferaseAfrican trypanosomiasisMajor vectorGenomeSNPsPrimary vectorMicrobiota in disease-transmitting vectors
Wang J, Gao L, Aksoy S. Microbiota in disease-transmitting vectors. Nature Reviews Microbiology 2023, 21: 604-618. PMID: 37217793, DOI: 10.1038/s41579-023-00901-6.Peer-Reviewed Original ResearchConceptsSymbiotic associationVector-borne diseasesDisease-transmitting vectorsAlternative control methodsVector competenceUnique key featuresHealth of humansSymbiotic microorganismsVector taxaReproductive strategiesArthropod hostsLife historyVector arthropodsHaematophagous arthropodsTriatomine bugsBlood feedVector populationsTransmission successArthropodsFeeding behaviorCurrent knowledgeMicrobiotaPathogensKnowledge gapsTaxa
2016
Mammalian African trypanosome VSG coat enhances tsetse’s vector competence
Aksoy E, Vigneron A, Bing X, Zhao X, O'Neill M, Wu YN, Bangs JD, Weiss BL, Aksoy S. Mammalian African trypanosome VSG coat enhances tsetse’s vector competence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 6961-6966. PMID: 27185908, PMCID: PMC4922192, DOI: 10.1073/pnas.1600304113.Peer-Reviewed Original ResearchConceptsVariant surface glycoproteinPeritrophic matrixMammalian hostsVector competenceTranscription factor familyMidgut homeostasisTsetse midgutTrypanosome biologyFactor familyPM barrierCoat proteinNovel functionAfrican trypanosomesTsetse vectorInfection processParasite developmentAnimal trypanosomiasesAntigenic variationVSG moleculesVSG coatBiological vectorsMidgutProtozoan parasiteDisease transmissionTsetse flies
1990
SLACS retrotransposon from Trypanosoma brucei gambiense is similar to mammalian LINEs
Aksoy S, Williams S, Chang S, Richards F. SLACS retrotransposon from Trypanosoma brucei gambiense is similar to mammalian LINEs. Nucleic Acids Research 1990, 18: 785-792. PMID: 2156231, PMCID: PMC330328, DOI: 10.1093/nar/18.4.785.Peer-Reviewed Original Research