2024
Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei
Beaver A, Keneskhanova Z, Cosentino R, Weiss B, Awuoche E, Smallenberger G, Buenconsejo G, Crilly N, Smith J, Hakim J, Zhang B, Bobb B, Rijo-Ferreira F, Figueiredo L, Aksoy S, Siegel T, Mugnier M. Tissue spaces are reservoirs of antigenic diversity for Trypanosoma brucei. Nature 2024, 1-8. PMID: 39478231, DOI: 10.1038/s41586-024-08151-z.Peer-Reviewed Original ResearchVariant surface glycoproteinAntigenic diversityAntigenic variationHigh-throughput sequencing approachDense variant surface glycoproteinPopulations of T. bruceiDynamics of antigenic variationGenomic repertoirePathogen diversificationSequencing approachExtravascular spaceTrypanosoma bruceiVariation in vivoHost immune systemAntigenic variation in vivoSurface glycoproteinSlow immune responseDiversitySwitching expressionParasite populations
2016
Mammalian African trypanosome VSG coat enhances tsetse’s vector competence
Aksoy E, Vigneron A, Bing X, Zhao X, O'Neill M, Wu YN, Bangs JD, Weiss BL, Aksoy S. Mammalian African trypanosome VSG coat enhances tsetse’s vector competence. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 6961-6966. PMID: 27185908, PMCID: PMC4922192, DOI: 10.1073/pnas.1600304113.Peer-Reviewed Original ResearchConceptsVariant surface glycoproteinPeritrophic matrixMammalian hostsVector competenceTranscription factor familyMidgut homeostasisTsetse midgutTrypanosome biologyFactor familyPM barrierCoat proteinNovel functionAfrican trypanosomesTsetse vectorInfection processParasite developmentAnimal trypanosomiasesAntigenic variationVSG moleculesVSG coatBiological vectorsMidgutProtozoan parasiteDisease transmissionTsetse flies