Featured Publications
Changes in Population-Level and Institutional-Level Prescribing Habits of Radioiodine Therapy for Papillary Thyroid Cancer
Jacobs D, Breen CT, Pucar D, Holt E, Judson BL, Mehra S. Changes in Population-Level and Institutional-Level Prescribing Habits of Radioiodine Therapy for Papillary Thyroid Cancer. Thyroid 2020, 31: 272-279. PMID: 32811347, DOI: 10.1089/thy.2020.0237.Peer-Reviewed Original ResearchConceptsPapillary thyroid cancerNational Cancer DatabaseThyroid cancerRadioactive iodine therapyNumber of patientsHospital-specific effectsIodine therapyAdvanced diseaseTotal thyroidectomyRadioiodine therapyPrescribing habitsRAI useCancer DatabaseMixed regression modelsPatientsJoinpoint analysisHospitalIndividual hospitalsCancerHospital selectionNational trendsThyroidectomyTherapySignificant declineRegression models
2020
Adjuvant external beam radiotherapy for surgically resected, nonmetastatic anaplastic thyroid cancer
Saeed NA, Kelly JR, Deshpande HA, Bhatia AK, Burtness BA, Judson BL, Mehra S, Edwards HA, Yarbrough WG, Peter PR, Holt EH, Decker RH, Husain ZA, Park HS. Adjuvant external beam radiotherapy for surgically resected, nonmetastatic anaplastic thyroid cancer. Head & Neck 2020, 42: 1031-1044. PMID: 32011055, DOI: 10.1002/hed.26086.Peer-Reviewed Original ResearchConceptsAnaplastic thyroid cancerLonger OSAdjuvant EBRTThyroid cancerAdjuvant external beam radiotherapyNational Cancer DatabaseExternal beam radiotherapyConcurrent chemoradiationConcurrent chemotherapyImproved survivalMedian ageCancer DatabaseRetrospective analysisBeam radiotherapyEBRTChemotherapyPatientsCancerUVAChemoradiationResectionRadiotherapy
2015
Response to “Breach of the thyroid capsule and lymph node capsule in node-positive papillary and medullary thyroid cancer: Different biology”
Rowe ME, Clain JB, Scherl S, Dos Reis L, Turk A, Wenig BM, Mehra S, Urken ML. Response to “Breach of the thyroid capsule and lymph node capsule in node-positive papillary and medullary thyroid cancer: Different biology”. European Journal Of Surgical Oncology 2015, 42: 156-157. PMID: 26632081, DOI: 10.1016/j.ejso.2015.09.029.Peer-Reviewed Original ResearchDatabase and Registry Research in Thyroid Cancer: Striving for a New and Improved National Thyroid Cancer Database
Mehra S, Tuttle RM, Milas M, Orloff L, Bergman D, Bernet V, Brett E, Cobin R, Doherty G, Judson BL, Klopper J, Lee S, Lupo M, Machac J, Mechanick JI, Randolph G, Ross DS, Smallridge R, Terris D, Tufano R, Alon E, Clain J, DosReis L, Scherl S, Urken ML. Database and Registry Research in Thyroid Cancer: Striving for a New and Improved National Thyroid Cancer Database. Thyroid 2015, 25: 157-168. PMID: 25517683, DOI: 10.1089/thy.2014.0270.Peer-Reviewed Original ResearchConceptsThyroid Cancer Care CollaborativeThyroid cancerCancer RegistryHealth registriesCancer managementPopulation-based cancer registriesDifferentiated thyroid cancerThyroid cancer databaseThyroid cancer managementQuality of careCancer researchSurveillance recommendationsCare CollaborativeOptimal treatmentCancer DatabaseRegistry researchDisease RegistryRegistryPatient carePhysician workflowCancerSpecific patientClinical researchCurrent registryDifferent treatment sites
2014
The Effect of Surgeon Experience on the Detection of Metastatic Lymph Nodes in the Central Compartment and the Pathologic Features of Clinically Unapparent Metastatic Lymph Nodes: What Are We Missing When We Don't Perform a Prophylactic Dissection of Central Compartment Lymph Nodes in Papillary Thyroid Cancer?
Scherl S, Mehra S, Clain J, Dos Reis L, Persky M, Turk A, Weing B, Husaini H, Urken M. The Effect of Surgeon Experience on the Detection of Metastatic Lymph Nodes in the Central Compartment and the Pathologic Features of Clinically Unapparent Metastatic Lymph Nodes: What Are We Missing When We Don't Perform a Prophylactic Dissection of Central Compartment Lymph Nodes in Papillary Thyroid Cancer? VideoEndocrinology 2014, 1 DOI: 10.1089/ve.2014.0022.Peer-Reviewed Original ResearchMetastatic lymph nodesLymph nodesPapillary thyroid cancerThyroid cancerSurgeon experienceProphylactic central neck dissectionCentral compartment lymph nodesSenior surgeon's assessmentAbnormal lymph nodesCentral neck dissectionProphylactic dissectionExtranodal extensionOccult metastasesNeck dissectionPathologic featuresRisk stratificationIntraoperative inspectionSurgeon's assessmentClinical assessmentSurgeon groupCentral compartmentLevel of agreementResident assessmentPoor sensitivityMetastasisIntrathyroidal Tumors Presenting with Extranodal Extension: What Are We Missing?
Clain JB, Mehra S, Scherl S, Dos Reis LL, Turk A, Wenig BM, Dewey EH, Urken ML. Intrathyroidal Tumors Presenting with Extranodal Extension: What Are We Missing? Endocrine Pathology 2014, 25: 385-389. PMID: 25325929, DOI: 10.1007/s12022-014-9340-9.Peer-Reviewed Original ResearchConceptsExtranodal extensionHistologic featuresIntrathyroidal tumorsLymphovascular invasionPerineural invasionLymphocytic thyroiditisLymph nodesPrimary tumorPsammoma bodiesNode-positive patientsPositive lymph nodesSubset of patientsFischer's exact testGroup A/BMann-Whitney testIntrathyroidal diseaseAggressive biologyPathologic featuresPoor prognosisTumor sizeThyroid cancerAggressive phenotypeExact testTumorsPatientsWhat Is the Gold Standard for Comprehensive Interinstitutional Communication of Perioperative Information for Thyroid Cancer Patients? A Comparison of Existing Electronic Health Records with the Current American Thyroid Association Recommendations
Dos Reis LL, Tuttle RM, Alon E, Bergman DA, Bernet V, Brett EM, Cobin R, Doherty G, Harris JR, Klopper J, Lee SL, Lupo M, Milas M, Machac J, Mechanick JI, Orloff L, Randolph G, Ross DS, Smallridge RC, Terris DJ, Tufano RP, Mehra S, Scherl S, Clain JB, Urken ML. What Is the Gold Standard for Comprehensive Interinstitutional Communication of Perioperative Information for Thyroid Cancer Patients? A Comparison of Existing Electronic Health Records with the Current American Thyroid Association Recommendations. Thyroid 2014, 24: 1466-1472. PMID: 25036190, DOI: 10.1089/thy.2014.0209.Peer-Reviewed Original ResearchConceptsThyroid Cancer Care CollaborativeAmerican Thyroid AssociationMemorial Sloan-Kettering Cancer CenterElectronic health recordsThyroid cancerPerioperative informationPatient informationAmerican Thyroid Association recommendationsCommon electronic health recordThyroid cancer surgeryIntraoperative fieldHealth recordsManagement of patientsThyroid cancer patientsAvailable electronic health recordsRelevant clinical informationElectronic reporting systemPostoperative coursePathologic assessmentCancer surgerySurgical managementCancer CenterCancer patientsCare CollaborativeThyroid AssociationThe Effect of Surgeon Experience on the Detection of Metastatic Lymph Nodes in the Central Compartment and the Pathologic Features of Clinically Unapparent Metastatic Lymph Nodes: What Are We Missing When We Don't Perform a Prophylactic Dissection of Central Compartment Lymph Nodes in Papillary Thyroid Cancer?
Scherl S, Mehra S, Clain J, Dos Reis LL, Persky M, Turk A, Wenig B, Husaini H, Urken ML. The Effect of Surgeon Experience on the Detection of Metastatic Lymph Nodes in the Central Compartment and the Pathologic Features of Clinically Unapparent Metastatic Lymph Nodes: What Are We Missing When We Don't Perform a Prophylactic Dissection of Central Compartment Lymph Nodes in Papillary Thyroid Cancer? Thyroid 2014, 24: 1282-1288. PMID: 24787362, DOI: 10.1089/thy.2013.0600.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCarcinomaCarcinoma, PapillaryFalse Negative ReactionsFalse Positive ReactionsFemaleHashimoto DiseaseHumansIntraoperative PeriodLymph NodesLymphatic MetastasisMaleMiddle AgedNeck DissectionProfessional CompetenceRiskSensitivity and SpecificitySurgeonsThyroid Cancer, PapillaryThyroid NeoplasmsThyroidectomyYoung AdultConceptsProphylactic central neck dissectionPapillary thyroid cancerMetastatic lymph nodesExtranodal extensionLymph nodesOccult metastasesPositive nodesSurgeon experienceOccult nodesPathologic featuresThyroid cancerPresence of ENECentral compartment lymph nodesAdverse histologic featuresMultiple positive nodesPositive central nodesSenior surgeon's assessmentCentral neck dissectionFalse-negative casesGroup of surgeonsEvident nodesPreoperative evidenceProphylactic dissectionNeck dissectionRisk stratificationExtrathyroidal Extension Predicts Extranodal Extension in Patients with Positive Lymph Nodes: An Important Association That May Affect Clinical Management
Clain JB, Scherl S, Dos Reis L, Turk A, Wenig BM, Mehra S, Karle WE, Urken ML. Extrathyroidal Extension Predicts Extranodal Extension in Patients with Positive Lymph Nodes: An Important Association That May Affect Clinical Management. Thyroid 2014, 24: 951-957. PMID: 24443878, DOI: 10.1089/thy.2013.0557.Peer-Reviewed Original ResearchConceptsExtranodal extensionLymph nodesPrimary tumorPresence of ENEAmerican Pathologists (CAP) protocolNode-positive patientsPositive lymph nodesRecurrent lymph nodesUpstaging of patientsMajority of patientsAggressive disease biologyLong-term survivalPresence of extensionCompletion thyroidectomyPositive nodesNodal metastasisRetrospective reviewHistologic featuresClinical managementDisease aggressivenessThyroid cancerT4 casesThyroid carcinomaHigh incidencePatients