Featured Publications
Characteristics and Outcomes of Sepsis Presenting in Inpatient Pediatric Settings.
Schafer M, Gruhler De Souza H, Paul R, Riggs R, Richardson T, Conlon P, Duffy S, Foster L, Gunderson J, Hall D, Hatcher L, Hess L, Kirkpatrick L, Kunar J, Lockwood J, Lowerre T, McFadden V, Raghavan A, Rizzi J, Stephen R, Stokes S, Workman J, Kandil S. Characteristics and Outcomes of Sepsis Presenting in Inpatient Pediatric Settings. Hospital Pediatrics 2022, 12: 1048-1059. PMID: 36345706, DOI: 10.1542/hpeds.2022-006592.Peer-Reviewed Original ResearchConceptsSepsis-attributable mortalitySepsis casesVasopressor useInpatient casesRetrospective cohort studyIntensive care admissionInpatient pediatric settingLonger lengthSepsis literatureTreatment bundleCare admissionInpatient cohortBundle adherenceClinical characteristicsCohort studySepsis outcomeSepsis recognitionChildren's HospitalIntensive careMortality outcomesLeading causeInpatient settingPediatric settingData registryED cases
2024
Adopting a Proactive Safety Approach: Creating a CLABSI Rapid Response Team
Edwards L, Garcia L, Murray T, Kandil S. Adopting a Proactive Safety Approach: Creating a CLABSI Rapid Response Team. Pediatric Quality And Safety 2024, 9: e761. PMCID: PMC11424128, DOI: 10.1097/pq9.0000000000000761.Peer-Reviewed Original ResearchYounger Age and Female Gender Are Associated With Delayed Antibiotics in Pediatric Sepsis
Kandil S, Lee S, Feinn R, Murray T. Younger Age and Female Gender Are Associated With Delayed Antibiotics in Pediatric Sepsis. Journal Of The Pediatric Infectious Diseases Society 2024, 13: 434-438. PMID: 38889196, DOI: 10.1093/jpids/piae064.Peer-Reviewed Original ResearchResilience Curriculum Improves Skills of Pediatric Fellows in Delivery of Difficult News.
Murtha T, Hafler J, Taylor E, Tala J, Asnes A, Massaro S, Kandil S. Resilience Curriculum Improves Skills of Pediatric Fellows in Delivery of Difficult News. Rhode Island Medical Journal 2024, 107: 49-53. PMID: 38687270.Peer-Reviewed Original ResearchConceptsDelivering difficult newsAmerican Academy of PediatricsDifficult newsSelf-efficacyPediatric fellowsResilience curriculumDelivery of difficult newsSimulated patient encountersIncreased self-efficacyAcademy of PediatricsStandardized patientsPatient encountersPediatric traineesAmerican AcademyFellow performanceChecklist scoresImprove confidenceImprove skillsPediatricFellowSkillsConfidenceNewsPatients
2023
1841. Younger age and female gender are associated with delayed antibiotics in pediatric sepsis
Kandil S, Lee S, Feinn R, Murray T. 1841. Younger age and female gender are associated with delayed antibiotics in pediatric sepsis. Open Forum Infectious Diseases 2023, 10: ofad500.1669. PMCID: PMC10678741, DOI: 10.1093/ofid/ofad500.1669.Peer-Reviewed Original ResearchAntibiotic administrationSepsis severityFemale genderNeonatal intensive care unitRetrospective cohort reviewDiagnosis of sepsisIntensive care unitExposure of interestChi-square testingPediatric sepsis mortalityIntravenous antibioticsCare bundleICU admissionCohort reviewSepsis mortalitySepsis recognitionPrimary outcomeCare unitFemale patientsHospital diagnosisLevel carePediatric sepsisAntibiotic delayBackground SepsisPediatric mortalityA quality improvement approach to integrating social determinants of health objectives into pediatric simulation
Feick M, Iqbal A, Boolchandani H, Kandil S, Johnston L, Soma G, Cordone A, Auerbach M, Tiyyagura G. A quality improvement approach to integrating social determinants of health objectives into pediatric simulation. AEM Education And Training 2023, 7: e10910. PMID: 37791136, PMCID: PMC10543355, DOI: 10.1002/aet2.10910.Peer-Reviewed Original ResearchSocial determinantsQuality improvement approachQuality improvement workEquitable careHealth outcomesHealth disparitiesLack of timeHealth objectivesSimulation curriculumPediatric residentsStudy periodPercentage of simulationsResidency programsReview of interviewsMost traineesMonthsMonthly casesPrimary objectiveSDHFacilitator feedbackImprovement approachPercentageResidentsPediatric simulationCasesBundled Care to Reduce Sepsis Mortality: The Improving Pediatric Sepsis Outcomes (IPSO) Collaborative.
Paul R, Niedner M, Riggs R, Richardson T, DeSouza H, Auletta J, Balamuth F, Campbell D, Depinet H, Hueschen L, Huskins W, Kandil S, Larsen G, Mack E, Priebe G, Rutman L, Schafer M, Scott H, Silver P, Stalets E, Wathen B, Macias C, Brilli R. Bundled Care to Reduce Sepsis Mortality: The Improving Pediatric Sepsis Outcomes (IPSO) Collaborative. Pediatrics 2023, 152 PMID: 37435672, DOI: 10.1542/peds.2022-059938.Peer-Reviewed Original ResearchConceptsSepsis-attributable mortalityCare bundleSepsis outcomeSepsis patientsEvidence-based care bundleChildren's Hospital AssociationGreater mortality reductionHospital AssociationSepsis care bundlesIC cohortISS cohortSepsis mortalityOrgan dysfunctionSepsis bundleSeptic shockPediatric sepsisChildren's HospitalSpecial cause variationBundle complianceMortality reductionImproved outcomesTimely treatmentPearson χKruskal-Wallis testMortality
2020
Harnessing Technology to Reduce Hospital Onset Sepsis
Vinhais-Luysterborghs N, Brester D, Vinchesi C, Ciaburri R, Emerson B, Murray T, Panisello J, Kandil S. Harnessing Technology to Reduce Hospital Onset Sepsis. Pediatric Quality And Safety 2020, 5: e325. PMCID: PMC7417151, DOI: 10.1097/pq9.0000000000000325.Peer-Reviewed Original Research
2019
27. EFFECTIVENESS OF DELIVERING DIFFICULT NEWS TRAINING: IMPROVED SKILLS AND SELF-EFFICACY OF PEDIATRIC TRAINEES
Murtha T, Taylor E, Tala J, Asnes A, Hafler J, Massaro S, Kandil S. 27. EFFECTIVENESS OF DELIVERING DIFFICULT NEWS TRAINING: IMPROVED SKILLS AND SELF-EFFICACY OF PEDIATRIC TRAINEES. Academic Pediatrics 2019, 19: e13-e14. DOI: 10.1016/j.acap.2019.05.041.Peer-Reviewed Original Research
2018
413
Srinivasan V, Hasbani N, Asaro L, Mehta N, Irving S, Kandil S, Allen C, Typpo K, Cvijanovich N, Faustino E, Wypij D, Agus M, Nadkarni V. 413. Critical Care Medicine 2018, 46: 190. DOI: 10.1097/01.ccm.0000528431.32594.04.Peer-Reviewed Original Research
2016
Vitamin D Status After Cardiopulmonary Bypass in Children With Congenital Heart Disease
Zahr R, Faustino EV, Carpenter T, Kirshbom P, Hall EK, Fahey JT, Kandil SB. Vitamin D Status After Cardiopulmonary Bypass in Children With Congenital Heart Disease. Journal Of Intensive Care Medicine 2016, 32: 508-513. PMID: 27251108, DOI: 10.1177/0885066616652077.Peer-Reviewed Original ResearchConceptsCongenital heart diseasePg/mLCardiopulmonary bypassVitamin D binding proteinD binding proteinHeart diseaseAlbumin levelsTime pointsVitamin D deficiencyVitamin D statusProspective observational studyMean levelsFree fractionD deficiencyD statusDihydroxyvitamin DObservational studySurgeryBinding proteinBypassDiseaseMeasures analysisChildrenDeficiencyML
2014
A pediatric critical care perspective on vitamin D
Abou-Zahr R, Kandil SB. A pediatric critical care perspective on vitamin D. Pediatric Research 2014, 77: 164-167. PMID: 25314583, DOI: 10.1038/pr.2014.167.Peer-Reviewed Original ResearchConceptsVitamin DCardiac diseaseIntensive care unit stayLow vitamin D levelsCritical care perspectiveMore fluid resuscitationVitamin D levelsVitamin D supplementationVitamin D deficiencyVitamin D statusCongestive heart failureSeverity of illnessPostoperative cardiac patientsPediatric cardiac populationMechanism of actionD supplementationInotrope supportNoncardiac populationUnit stayD deficiencyD statusCritical illnessFluid resuscitationHeart failureClinical outcomesAssessing the benefits and risks of tight glycemic control in critically ill children
Faustino E, Kandil S. Assessing the benefits and risks of tight glycemic control in critically ill children. Pediatric Health Medicine And Therapeutics 2014, Volume 5: 93-98. DOI: 10.2147/phmt.s50410.Peer-Reviewed Original ResearchTight glycemic controlIntensive care unitIll childrenGlycemic controlCare unitSurgical intensive care unitSubsequent multicenter trialSingle-center trialInsulin-induced hypoglycemiaIntravenous insulinCenter trialIll adultsIll patientsMulticenter trialTrialsHypoglycemiaChildrenHigh rateMortalityCurrent literatureInsulinRiskHyperglycemiaPatientsTight glycaemic control does not improve mortality or morbidity in critically ill children
Kandil SB, Faustino EV. Tight glycaemic control does not improve mortality or morbidity in critically ill children. BMJ Evidence-Based Medicine 2014, 19: 143. PMID: 24591541, DOI: 10.1136/eb-2014-101749.Peer-Reviewed Original Research
2013
Retrospective Outcomes of Glucose Control in Critically Ill Children
Kandil SB, Spear D, Thomas NJ, Weinzimer SA, Faustino EV. Retrospective Outcomes of Glucose Control in Critically Ill Children. Journal Of Diabetes Science And Technology 2013, 7: 1220-1228. PMID: 24124949, PMCID: PMC3876366, DOI: 10.1177/193229681300700512.Peer-Reviewed Original ResearchConceptsIll childrenGlucose controlBlood glucoseTreatment groupsBaseline groupVasopressor-free daysVentilator-free daysCritically Ill ChildrenIntensive care unitMean blood glucoseBlood glucose controlICU stayRetrospective cohortPatient characteristicsCare unitRandomized trialsHistorical cohortRetrospective outcomesWorse outcomesGlucose metricsHyperglycemiaSimilar childrenFree daysDlConflicting resultsControl of serum glucose concentration in critical illness
Kandil SB, Miksa M, Faustino EV. Control of serum glucose concentration in critical illness. Current Opinion In Pediatrics 2013, 25: 297-303. PMID: 23657243, DOI: 10.1097/mop.0b013e328360c6a0.Peer-Reviewed Original ResearchConceptsTight glycemic controlIll childrenPostoperative cardiac surgery patientsCardiac surgery patientsInsulin-induced hypoglycemiaRisk of deathSerum glucose concentrationLong-term safetyCritical illnessSurgery patientsGlycemic controlPediatric patientsClinical benefitCardiac patientsAdult studiesLatest evidenceNeurocognitive developmentHypoglycemiaPatientsAdverse effectsDiscrepant resultsGlucose concentrationHyperglycemiaChildrenTrials
2012
Transport Disposition Using the Transport Risk Assessment in Pediatrics (TRAP) Score
Kandil SB, Sanford H, Northrup V, Bigham MT, Giuliano JS. Transport Disposition Using the Transport Risk Assessment in Pediatrics (TRAP) Score. Prehospital Emergency Care 2012, 16: 366-373. PMID: 22443350, PMCID: PMC3360797, DOI: 10.3109/10903127.2012.664246.Peer-Reviewed Original ResearchConceptsPediatric patientsPICU admissionTransport teamPediatric intensive care unit admissionIntensive care unit admissionCare unit admissionTertiary care centerPediatric specialty transport teamInitial assessmentUnit admissionChart reviewChildren's HospitalDirect admissionCare centerObservational studyHigher scoresPatientsPediatric scoresPhysiologic variablesScore's abilityAdmissionLogistic regressionTriage decisionsSpecialized teamTRAP scores
2001
The influence of the phase of the estrous cycle on sheep endometrial tissue response to lipopolysaccharide.
Vagnoni KE, Abbruzzese SB, Christiansen ND, Holyoak GR. The influence of the phase of the estrous cycle on sheep endometrial tissue response to lipopolysaccharide. Journal Of Animal Science 2001, 79: 463-9. PMID: 11219456.Peer-Reviewed Original Research
Others
- Kandil S, Faustino, EV. Outcomes of Tight Glycemic Control in Critically Ill Children. Pediatric Academic Society. 2011. (Abstract)Peer-Reviewed Original Research
- Canarie MF, Barry S, Carroll CL, Hassinger A, Kandil S, Li S, Pinto M, Valentine SL, Faustino EV; Northeast Pediatric Critical Care Research Consortium. Risk Factors for Delayed Enteral Nutrition in Critically Ill Children. Pediatr Crit Care Med. 2015 Oct;16(8):e283-9.Peer-Reviewed Original Research