2001
Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol44Abbreviations: MC, mitomycin C; DIC, dicumarol; 2,7-DAM, 2,7-diaminomitosene; and XDH, xanthine dehydrogenase.
Palom Y, Belcourt M, Tang L, Mehta S, Sartorelli A, Pritsos C, Pritsos K, Rockwell S, Tomasz M. Bioreductive metabolism of mitomycin C in EMT6 mouse mammary tumor cells: cytotoxic and non-cytotoxic pathways, leading to different types of DNA adducts. The effect of dicumarol44Abbreviations: MC, mitomycin C; DIC, dicumarol; 2,7-DAM, 2,7-diaminomitosene; and XDH, xanthine dehydrogenase. Biochemical Pharmacology 2001, 61: 1517-1529. PMID: 11377381, DOI: 10.1016/s0006-2952(01)00609-8.Peer-Reviewed Original Research
1995
Cytotoxic potential of monoalkylation products between mitomycins and DNA: studies of decarbamoyl mitomycin C in wild-type and repair-deficient cell lines.
Rockwell S, Kim S. Cytotoxic potential of monoalkylation products between mitomycins and DNA: studies of decarbamoyl mitomycin C in wild-type and repair-deficient cell lines. Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 1995, 7: 39-47. PMID: 7549043.Peer-Reviewed Original Research
1991
Diarylsulfonylureas and Radiotherapy I. In Vitro Studies with N-(5-Indanylsulfonyl)-N′-(4-chlorophenyl)-urea (Sulofenur)
Rockwell S, Grindey G. Diarylsulfonylureas and Radiotherapy I. In Vitro Studies with N-(5-Indanylsulfonyl)-N′-(4-chlorophenyl)-urea (Sulofenur). Oncology Research Featuring Preclinical And Clinical Cancer Therapeutics 1991, 3: 103-108. PMID: 2025495, DOI: 10.3727/095535491820873434.Peer-Reviewed Original ResearchConceptsEMT6 mouse mammary tumor cellsMouse mammary tumor cellsMammary tumor cellsAcute hypoxiaSolid tumorsSulofenurTumor cellsCytotoxic effectsCulture mediumVitro studyPlateau-phase culturesDiarylsulfonylureasCytotoxicityDrugsFurther examinationProliferative stateMonolayer culturesQuiescent cellsTreatmentCritical determinantCellsRadiotherapy