2008
BAX activation is initiated at a novel interaction site
Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng E, Tjandra N, Walensky LD. BAX activation is initiated at a novel interaction site. Nature 2008, 455: 1076-1081. PMID: 18948948, PMCID: PMC2597110, DOI: 10.1038/nature07396.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsApoptosisApoptosis Regulatory ProteinsBcl-2-Associated X ProteinBcl-2-Like Protein 11BH3 Interacting Domain Death Agonist ProteinCell LineGene Expression RegulationHumansMembrane ProteinsMiceMutagenesis, Site-DirectedMutationNuclear Magnetic Resonance, BiomolecularProtein BindingProto-Oncogene ProteinsSequence AlignmentConceptsAnti-apoptotic proteinsInteraction sitesBax activationBax-mediated cell deathBCL-2 domainsCell deathBcl-2 familyNovel interaction sitePro-apoptotic proteinsPoint mutagenesisMitochondrial apoptosisBax interactionStress stimuliΑ-helixProteinNew targetsBaxTherapeutic modulationDirect activationActivation siteApoptosisActivationFunctional activitySitesMutagenesis
2002
Interaction between FOG-1 and the Corepressor C-Terminal Binding Protein Is Dispensable for Normal Erythropoiesis In Vivo
Katz SG, Cantor AB, Orkin SH. Interaction between FOG-1 and the Corepressor C-Terminal Binding Protein Is Dispensable for Normal Erythropoiesis In Vivo. Molecular And Cellular Biology 2002, 22: 3121-3128. PMID: 11940669, PMCID: PMC133767, DOI: 10.1128/mcb.22.9.3121-3128.2002.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol OxidoreductasesAmino Acid MotifsAmino Acid SequenceAnimalsBinding SitesBlotting, WesternCarrier ProteinsCell LineConserved SequenceCOS CellsDNA-Binding ProteinsErythrocytesErythropoiesisErythropoietinGenetic VectorsHematocritMiceMice, KnockoutMutationNuclear ProteinsPhenylhydrazinesPhosphoproteinsPrecipitin TestsProtein BindingRepressor ProteinsSequence Homology, Amino AcidTranscription FactorsTransgenesConceptsC-terminal binding proteinFOG-1Corepressor C-terminal binding proteinTranscription factor GATA-1Binding proteinCorepressor CtBPCtBP interactsErythroid developmentGATA-1Vivo functionCtBPMegakaryocytic lineagePeptide motifsPhysiological roleInteraction sitesNormal erythropoiesisErythropoietic stressCell linesStages of developmentProteinErythrocyte productionFamily membersWild-type miceErythropoiesisCoimmunoprecipitation