2003
Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development
Katz SG, Williams A, Yang J, Fujiwara Y, Tsang AP, Epstein JA, Orkin SH. Endothelial lineage-mediated loss of the GATA cofactor Friend of GATA 1 impairs cardiac development. Proceedings Of The National Academy Of Sciences Of The United States Of America 2003, 100: 14030-14035. PMID: 14614148, PMCID: PMC283540, DOI: 10.1073/pnas.1936250100.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsDNA-Binding ProteinsEndotheliumErythroid-Specific DNA-Binding FactorsFetal HeartGATA1 Transcription FactorHeart Defects, CongenitalHeart ValvesHematopoiesisIn Situ HybridizationMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNeural CrestNuclear ProteinsTranscription FactorsConceptsFOG-1GATA-4/5/6FOG-2Cardiac developmentConditional inactivationGATA transcription factorsDiverse cell typesNeural crest cellsNeural crest derivativesGata (FOG) cofactorsEmbryonic day 14.5Cofactor FriendTranscription factorsHematopoietic defectsHeart developmentCrest cellsTransgenic rescueCrest derivativesUnsuspected roleGATA-4Nonredundant requirementCell typesCell of originDay 14.5Atrioventricular valve
2002
Interaction between FOG-1 and the Corepressor C-Terminal Binding Protein Is Dispensable for Normal Erythropoiesis In Vivo
Katz SG, Cantor AB, Orkin SH. Interaction between FOG-1 and the Corepressor C-Terminal Binding Protein Is Dispensable for Normal Erythropoiesis In Vivo. Molecular And Cellular Biology 2002, 22: 3121-3128. PMID: 11940669, PMCID: PMC133767, DOI: 10.1128/mcb.22.9.3121-3128.2002.Peer-Reviewed Original ResearchMeSH KeywordsAlcohol OxidoreductasesAmino Acid MotifsAmino Acid SequenceAnimalsBinding SitesBlotting, WesternCarrier ProteinsCell LineConserved SequenceCOS CellsDNA-Binding ProteinsErythrocytesErythropoiesisErythropoietinGenetic VectorsHematocritMiceMice, KnockoutMutationNuclear ProteinsPhenylhydrazinesPhosphoproteinsPrecipitin TestsProtein BindingRepressor ProteinsSequence Homology, Amino AcidTranscription FactorsTransgenesConceptsC-terminal binding proteinFOG-1Corepressor C-terminal binding proteinTranscription factor GATA-1Binding proteinCorepressor CtBPCtBP interactsErythroid developmentGATA-1Vivo functionCtBPMegakaryocytic lineagePeptide motifsPhysiological roleInteraction sitesNormal erythropoiesisErythropoietic stressCell linesStages of developmentProteinErythrocyte productionFamily membersWild-type miceErythropoiesisCoimmunoprecipitation
2001
Friend of GATA-1 Represses GATA-3–dependent Activity in CD4+ T Cells
Zhou M, Ouyang W, Gong Q, Katz S, White J, Orkin S, Murphy K. Friend of GATA-1 Represses GATA-3–dependent Activity in CD4+ T Cells. Journal Of Experimental Medicine 2001, 194: 1461-1471. PMID: 11714753, PMCID: PMC2193678, DOI: 10.1084/jem.194.10.1461.Peer-Reviewed Original ResearchConceptsFOG-1Friend of GATATranscription factor activityActivator of transcriptionIL-5 promoterHematopoietic developmentMegakaryocyte differentiationSignal transducerGATA-3Dependent inductionFactor activityNaive T cellsTh2 developmentT cellsOverexpressionAutoactivationCellsGATA-3 expressionPrimary activationActivationInductionTranscriptionPromoterGATAProtein