2017
Bok Promotes Erythropoiesis in a Mouse Model of Myelodysplastic Syndrome
Kang S, Perales O, Michuad M, Katz S. Bok Promotes Erythropoiesis in a Mouse Model of Myelodysplastic Syndrome. Blood 2017, 130: 922. DOI: 10.1182/blood.v130.suppl_1.922.922.Peer-Reviewed Original ResearchAcute myeloid leukemiaNHD13 miceMean cell hemoglobin concentrationMouse modelBone marrowMean cell volumeMDS/acute myeloid leukemiaRBC progenitorsUnfolded protein responseSimilar overall survivalTransgenic mouse modelPathogenesis of myelodysplasiaER stressHigher mean cell volumeLower mean cell hemoglobin concentrationCell hemoglobin concentrationAnti-apoptotic Bcl-2Endoplasmic reticulum stressOverall survivalProgenitor stem cellsRed blood cellsLower hemoglobinMyelodysplastic syndromeMyeloid leukemiaRegulation of erythropoiesis
2015
SOX11 Cooperates with CCND1 in Mantle Cell Lymphoma Pathogenesis
Kuo P, Jiang Z, Perumal D, Leshchenko V, Lagana' A, Katz S, Walensky L, Shaknovich R, Ye B, Parekh S. SOX11 Cooperates with CCND1 in Mantle Cell Lymphoma Pathogenesis. Blood 2015, 126: 1253. DOI: 10.1182/blood.v126.23.1253.1253.Peer-Reviewed Original ResearchTransgenic mouse modelB cell populationsMouse modelB cellsBone marrowTransgenic micePeripheral bloodPeritoneal cavitySOX11 expressionDouble transgenic mouse modelIncurable B-cell malignancySingle transgenic miceB-cell hyperplasiaB-cell phenotypeWild-type miceCell populationsB-cell malignanciesRole of SOX11Multiple oncogenic pathwaysCyclin D1 overexpressionMCL pathogenesisMCL tumorsExpression of SOX11Key diagnostic featuresMedian survival
2010
A Stapled BIM BH3 Helix Restores Apoptosis In Bim-Null Mantle Cell Lymphoma
Katz S, Labelle J, Godes M, Fisher J, Bird G, Walensky L. A Stapled BIM BH3 Helix Restores Apoptosis In Bim-Null Mantle Cell Lymphoma. Blood 2010, 116: 437. DOI: 10.1182/blood.v116.21.437.437.Peer-Reviewed Original ResearchMantle cell lymphomaCell lymphomaAggressive B-cell lymphomasDevelopment of splenomegalyRAG2-deficient miceB-cell lymphomaLymphoproliferative diseaseOrgan infiltrationMCL cell linesConventional chemotherapyHematologic cancersAnti-apoptotic proteinsBone marrowNormal parenchymaVivo modelPro-apoptotic proteinsCell-permeable peptideLymphomaPro-apoptotic activityGenetic aberrationsMiceBcl-2TUNEL positivityPro-apoptotic Bcl-2 family protein BimCaspase-3/7