2015
Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis
Erson-Omay EZ, Çağlayan AO, Schultz N, Weinhold N, Omay SB, Özduman K, Köksal Y, Li J, Serin Harmancı A, Clark V, Carrión-Grant G, Baranoski J, Çağlar C, Barak T, Coşkun S, Baran B, Köse D, Sun J, Bakırcıoğlu M, Moliterno Günel J, Pamir MN, Mishra-Gorur K, Bilguvar K, Yasuno K, Vortmeyer A, Huttner AJ, Sander C, Günel M. Somatic POLE mutations cause an ultramutated giant cell high-grade glioma subtype with better prognosis. Neuro-Oncology 2015, 17: 1356-1364. PMID: 25740784, PMCID: PMC4578578, DOI: 10.1093/neuonc/nov027.Peer-Reviewed Original ResearchConceptsHigh-grade gliomasSomatic POLE mutationsPOLE mutationsMalignant high-grade gliomasLonger progression-free survivalProgression-free survivalSomatic mutationsOverall survivalPediatric patientsBetter prognosisClinical featuresImproved prognosisClinical behaviorImmune cellsBizarre cellsAggressive formGlioblastoma multiformeDisease pathophysiologyMolecular subgroupsHomozygous germline mutationGermline mutationsPrognosisGlioma subtypesComprehensive genomic analysisDistinct subgroups
2012
Decompressive hemicraniectomy for ischemic stroke in the pediatric population
Omay SB, Carrión-Grant GM, Kuzmik GA, Fu M, Grant R, Schindler JL, Diluna ML, Duncan CC, Bulsara KR. Decompressive hemicraniectomy for ischemic stroke in the pediatric population. Neurosurgical Review 2012, 36: 21-25. PMID: 22886322, DOI: 10.1007/s10143-012-0411-4.Peer-Reviewed Original ResearchConceptsDecompressive hemicraniectomyPediatric populationAdult patientsSpace-occupying hemispheric infarctionMaximal medical therapyMalignant strokeHemispheric infarctionIschemic strokeSymptom onsetMedical therapyPediatric patientsPoor prognosisTreatment optionsPediatric literatureFatality ratePatientsAdult populationPediatric interventionsPositive outcomesOptimal timingHemicraniectomyReasonable outcomesOutcomesStrokeCurrent literature