2023
A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures
Kuhn R, Barrett A, Desilva A, Harris E, Kramer L, Montgomery R, Pierson T, Sette A, Diamond M. A Prototype-Pathogen Approach for the Development of Flavivirus Countermeasures. The Journal Of Infectious Diseases 2023, 228: s398-s413. PMID: 37849402, PMCID: PMC10582523, DOI: 10.1093/infdis/jiad193.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFlavivirusFlavivirus InfectionsHumansMosquito VectorsVaccinesZika VirusZika Virus InfectionConceptsFamily of positive-strand RNA virusesPositive-strand RNA virusesSelf-limited febrile syndromeSpread of flavivirusesRNA virusesPrototype flavivirusDevelopment of vaccinesFebrile syndromePandemic potentialYellow fever virusFlaviviridae familyHuman infectionsViscerotropic diseaseZika virusTick vectorFever virusFlavivirusesDengue virusVaccineVirusGenus
2020
Single cell immune profiling of dengue virus patients reveals intact immune responses to Zika virus with enrichment of innate immune signatures
Zhao Y, Amodio M, Vander Wyk B, Gerritsen B, Kumar MM, van Dijk D, Moon K, Wang X, Malawista A, Richards MM, Cahill ME, Desai A, Sivadasan J, Venkataswamy MM, Ravi V, Fikrig E, Kumar P, Kleinstein SH, Krishnaswamy S, Montgomery RR. Single cell immune profiling of dengue virus patients reveals intact immune responses to Zika virus with enrichment of innate immune signatures. PLOS Neglected Tropical Diseases 2020, 14: e0008112. PMID: 32150565, PMCID: PMC7082063, DOI: 10.1371/journal.pntd.0008112.Peer-Reviewed Original ResearchConceptsZika virusCell subsetsDengue virusConcurrent dengue infectionInnate cell responsesInnate immune signaturesVirus-infected individualsDivergent clinical outcomesMosquito-borne human pathogenIntact immune responsePre-existing infectionInnate cell typesSingle-cell immune profilingPublic health importanceCell typesImmune signaturesVirus patientsWest Nile virusAcute patientsClinical outcomesImmune profilingDengue infectionImmune statusFunctional statusImmune cells
2019
Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice
Uraki R, Hastings AK, Marin-Lopez A, Sumida T, Takahashi T, Grover JR, Iwasaki A, Hafler DA, Montgomery RR, Fikrig E. Aedes aegypti AgBR1 antibodies modulate early Zika virus infection of mice. Nature Microbiology 2019, 4: 948-955. PMID: 30858571, PMCID: PMC6533137, DOI: 10.1038/s41564-019-0385-x.Peer-Reviewed Original ResearchConceptsZika virus infectionVirus infectionZika virusAegypti salivary proteinsGuillain-Barre syndromeEarly inflammatory responseSkin of micePrevention of mosquitoInflammatory responseAedes aegypti mosquitoesTherapeutic measuresSalivary factorsSalivary proteinsMosquito-borneInfectionMiceSubstantial mortalityRecent epidemicProtein 1Aegypti mosquitoesAntigenic proteinsVirusAntibodiesMosquitoesAntiserum