2014
Protective Effect of Methicillin-Susceptible Staphylococcus aureus Carriage against Methicillin-Resistant S. aureus Acquisition in Nursing Homes: A Prospective Cross-Sectional Study
Datta R, Quan V, Kim D, Peterson EM, Reynolds C, Meyers H, Cheung M, Huang SS. Protective Effect of Methicillin-Susceptible Staphylococcus aureus Carriage against Methicillin-Resistant S. aureus Acquisition in Nursing Homes: A Prospective Cross-Sectional Study. Infection Control And Hospital Epidemiology 2014, 35: 1257-1262. PMID: 25203179, DOI: 10.1086/678062.Peer-Reviewed Original ResearchConceptsProspective cross-sectional studyCross-sectional studyS. aureus prevalencePoint prevalenceAdmission prevalenceNursing homesAureus prevalenceInverse associationMethicillin-resistant S. aureus (MRSA) prevalenceS. aureus acquisitionMethicillin-susceptible Staphylococcus aureus (MSSA) carriageDay of admissionStaphylococcus aureus carriageNursing home stayBlood agarMinimal associationMSSA carriageAureus carriageMRSA acquisitionPercentage of residentsNares swabsProtective effectSkin lesionsTotal swabsSheep blood agarConfounding by indication affects antimicrobial risk factors for methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition
Datta R, Kleinman K, Rifas-Shiman S, Placzek H, Lankiewicz J, Platt R, Huang SS, for the CDC Prevention Epicenters. Confounding by indication affects antimicrobial risk factors for methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition. Antimicrobial Resistance & Infection Control 2014, 3: 19. PMID: 24932407, PMCID: PMC4057914, DOI: 10.1186/2047-2994-3-19.Peer-Reviewed Original ResearchMethicillin-resistant Staphylococcus aureusVancomycin-resistant enterococci acquisitionEmpiric antibioticsRisk factorsVRE acquisitionAntibiotic prescriptionsMRSA acquisitionScreening culturesIntensive care unit patientsAntibiotic utilization dataMRSA-positive patientsVRE-positive patientsCare unit patientsMedical record reviewDiagnosis of infectionEvidence of treatmentSymptoms of infectionStaphylococcus aureusBackgroundObservational studiesEmpiric therapyUnit patientsRecord reviewTreatment indicationsPrior historyLow prevalence
2011
Colonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control study
Huang SS, Datta R, Rifas-Shiman S, Kleinman K, Placzek H, Lankiewicz JD, Platt R. Colonization with antibiotic-susceptible strains protects against methicillin-resistant Staphylococcus aureus but not vancomycin-resistant enterococci acquisition: a nested case-control study. Critical Care 2011, 15: r210. PMID: 21914221, PMCID: PMC3334754, DOI: 10.1186/cc10445.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusMethicillin-sensitive Staphylococcus aureusVancomycin-resistant enterococciInitial negative swabCase-control studyVancomycin-sensitive enterococciMRSA acquisitionVRE acquisitionICU admissionRisk factorsNegative swabsStaphylococcus aureusHigh endemic settingMRSA-positive patientsVancomycin-resistant enterococci acquisitionThird-generation cephalosporinsSensitive strainsPredictors of acquisitionBilateral naresMSSA carriageMSSA infectionsSame hospitalizationICU patientsLow albuminMRSA infectionEnvironmental Cleaning Intervention and Risk of Acquiring Multidrug-Resistant Organisms From Prior Room Occupants
Datta R, Platt R, Yokoe DS, Huang SS. Environmental Cleaning Intervention and Risk of Acquiring Multidrug-Resistant Organisms From Prior Room Occupants. JAMA Internal Medicine 2011, 171: 491-494. PMID: 21444840, DOI: 10.1001/archinternmed.2011.64.Peer-Reviewed Original ResearchConceptsMethicillin-resistant Staphylococcus aureusRisk of acquisitionPrior room occupantsVancomycin-resistant enteroccociIntensive care unitCare unitIntervention periodAcquisition of MRSAIntensive care unit roomsRetrospective cohort studyMultidrug-resistant organismsAcademic medical centerEnvironmental cleaning interventionsVRE acquisitionEligible patientsMRSA carriersVRE transmissionCardiac surgeryCohort studyMRSA acquisitionNeurosurgery unitThoracic surgeryMedical CenterVRE carriersGeneral surgery