517. Subcutaneous Sarilumab for the Treatment of Hospitalized patients with Moderate to Severe COVID19 Disease: A Pragmatic, Embedded, Multi-Center Randomized Clinical Trial
Branch-Elliman W, Ferguson R, Doros G, Woods P, Leatherman S, Strymish J, Datta R, Goswami R, Jankowich M, Shah N, Taylor T, Page S, Schiller S, Shannon C, Hau C, Flynn M, Holmberg E, Visnaw K, Dhond R, Brophy M, Monach P. 517. Subcutaneous Sarilumab for the Treatment of Hospitalized patients with Moderate to Severe COVID19 Disease: A Pragmatic, Embedded, Multi-Center Randomized Clinical Trial. Open Forum Infectious Diseases 2021, 8: 360-360. PMCID: PMC8690689, DOI: 10.1093/ofid/ofab466.716.Peer-Reviewed Original ResearchSubcutaneous sarilumabStandard careMechanical ventilationLearning healthcare systemClinical trialsSevere COVID-19 diseaseCOVID-19Rate of intubationSevere COVID-19Trial of patientsCare clinical trialsIL-6 inhibitionTreatment of patientsNumber of patientsStandard of careHealthcare systemEvidence of benefitCOVID-19 diseaseData monitoring committeeA PragmaticPrimary endpointChart reviewHospitalized patientsPrimary outcomeSupplemental oxygen