2010
Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice
Skurnik D, Merighi M, Grout M, Gadjeva M, Maira-Litran T, Ericsson M, Goldmann DA, Huang SS, Datta R, Lee JC, Pier GB. Animal and human antibodies to distinct Staphylococcus aureus antigens mutually neutralize opsonic killing and protection in mice. Journal Of Clinical Investigation 2010, 120: 3220-3233. PMID: 20739753, PMCID: PMC2929724, DOI: 10.1172/jci42748.Peer-Reviewed Original ResearchConceptsS. aureus infectionPoly-N-acetyl glucosamineAureus infectionOpsonic killingCapsular polysaccharideNew prophylactic approachS. aureus bacteremiaCommunity-acquired infectionsStaphylococcus aureus antigenOPK activityAureus bacteremiaProtective immunityComplement depositionEffective immunityProphylactic approachMouse modelSuch antigensVaccine componentsIdiotype interactionsHuman immunityAnimal antiseraGram-positive bacterial pathogensHuman antibodiesInfectionMonoclonal antibodies
2006
Impact of Routine Intensive Care Unit Surveillance Cultures and Resultant Barrier Precautions on Hospital-Wide Methicillin-Resistant Staphylococcus aureus Bacteremia
Huang SS, Yokoe DS, Hinrichsen VL, Spurchise LS, Datta R, Miroshnik I, Platt R. Impact of Routine Intensive Care Unit Surveillance Cultures and Resultant Barrier Precautions on Hospital-Wide Methicillin-Resistant Staphylococcus aureus Bacteremia. Clinical Infectious Diseases 2006, 43: 971-978. PMID: 16983607, DOI: 10.1086/507636.Peer-Reviewed Original ResearchConceptsIntensive care unitContact isolation precautionsMRSA bacteremiaStaphylococcus aureus bacteremiaInfection control interventionsIsolation precautionsSurveillance culturesBarrier precautionsAureus bacteremiaIncidence densityHealth care-associated methicillin-resistant Staphylococcus aureus (MRSA) infectionsMethicillin-susceptible Staphylococcus aureus bacteremiaMethicillin-resistant Staphylococcus aureus (MRSA) infectionsControl interventionsMaximal sterile barrier precautionsResistant Staphylococcus aureus BacteremiaCentral venous catheter placementAlcohol-based hand rubHospital-wide reductionVenous catheter placementHand hygiene campaignRoutine surveillance culturesStaphylococcus aureus infectionInterrupted time series designBacteremia rates