2023
SMC5 Plays Independent Roles in Congenital Heart Disease and Neurodevelopmental Disability
O'Brien M, Pryzhkova M, Lake E, Mandino F, Shen X, Karnik R, Atkins A, Xu M, Ji W, Konstantino M, Brueckner M, Ment L, Khokha M, Jordan P. SMC5 Plays Independent Roles in Congenital Heart Disease and Neurodevelopmental Disability. International Journal Of Molecular Sciences 2023, 25: 430. PMID: 38203602, PMCID: PMC10779392, DOI: 10.3390/ijms25010430.Peer-Reviewed Original Research
2022
Opportunities to enhance parental well-being during prenatal counseling for congenital heart disease
Tacy TA, Kasparian NA, Karnik R, Geiger M, Sood E. Opportunities to enhance parental well-being during prenatal counseling for congenital heart disease. Seminars In Perinatology 2022, 46: 151587. PMID: 35461701, DOI: 10.1016/j.semperi.2022.151587.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsTraumatic stressTraumatic eventsComplex medical informationPsychological distressParental anxietyEarly parenthoodImportant skillExpectant parentsParentsCounselingAnxietyDistressSkillsParenthoodParticular diagnosisMedical decisionsUnborn childBeingDepressionTrainingChildrenElement of uncertaintyLongitudinal Assessment of Global and Regional Left Ventricular Strain in Patients with Multisystem Inflammatory Syndrome in Children (MIS-C)
He M, Leone DM, Frye R, Ferdman DJ, Shabanova V, Kosiv KA, Sugeng L, Faherty E, Karnik R. Longitudinal Assessment of Global and Regional Left Ventricular Strain in Patients with Multisystem Inflammatory Syndrome in Children (MIS-C). Pediatric Cardiology 2022, 43: 844-854. PMID: 34993558, PMCID: PMC8739007, DOI: 10.1007/s00246-021-02796-7.Peer-Reviewed Original ResearchConceptsMIS-C patientsAcute phaseChronic phaseInflammatory syndromeTwo-dimensional speckle tracking echocardiographySubclinical myocardial injuryCircumferential strainMultisystem inflammatory syndromeLeft ventricular dysfunctionSingle-institution reviewSpeckle tracking echocardiographyTwo-dimensional echocardiographyCoronavirus disease 2019Future adverse eventsVentricular function parametersBasal anterolateral segmentMean GCSVentricular dysfunctionAdverse eventsFractional shorteningSignificant sequelaeVentricular strainMyocardial dysfunctionGlobal longitudinalMyocardial injury
2021
A 13-Year-Old With Fever and Chest Pain
Soma G, Simmons MA, Canarie MF, Karnik R, Steele J, Tiyyagura G, Asnes J. A 13-Year-Old With Fever and Chest Pain. Pediatrics 2021, 148: e2021050960. PMID: 34344802, DOI: 10.1542/peds.2021-050960.Peer-Reviewed Case Reports and Technical Notes
2020
Resource Utilization in Implementation of a Point of Care Ultrasound Curriculum for Resident Training in Anesthesiology.
Deshpande R, Karnik R, Baer C, Kurup V. Resource Utilization in Implementation of a Point of Care Ultrasound Curriculum for Resident Training in Anesthesiology. The Yale Journal Of Biology And Medicine 2020, 93: 423-427. PMID: 32874148, PMCID: PMC7448394.Peer-Reviewed Original Research
2019
Cardiac Manifestations of Noonan Syndrome.
Karnik R, Geiger M. Cardiac Manifestations of Noonan Syndrome. Pediatric Endocrinology Reviews : PER 2019, 16: 471-476. PMID: 31115199, DOI: 10.17458/per.vol16.2019.kpg.manifestationsnoonan.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsLong-term prognosisDevelopment of cardiomyopathyCommon structural abnormalityPulmonary stenosisCardiac manifestationsMedical therapyTerm prognosisCardiovascular abnormalitiesHypertrophic cardiomyopathyCardiac diseaseCardiac pathologyStructural abnormalitiesRAF1 mutationsNoonan syndromePTPN11 mutationsInvolved pathwaysCardiomyopathyGenotype-phenotype associationsAbnormalitiesWide spectrumAssociationStenosisPrognosisSyndromeInfants
2018
Abnormalities in Left Ventricular Rotation Are Inherent in Young Children with Repaired Tetralogy of Fallot and Are Independent of Right Ventricular Dilation
Karnik R, Uppu SC, Tozzi M, Doucette J, Lytrivi ID, Geiger M, Klas B, Parness IA, Shenoy R, Rajagopal H, Srivastava S. Abnormalities in Left Ventricular Rotation Are Inherent in Young Children with Repaired Tetralogy of Fallot and Are Independent of Right Ventricular Dilation. Pediatric Cardiology 2018, 39: 1172-1180. PMID: 29644405, DOI: 10.1007/s00246-018-1877-9.Peer-Reviewed Original ResearchConceptsRight ventricular dilationRV dilationAbnormal ARLV systolicPulmonary regurgitationVentricular dilationRotational mechanicsApical rotationYoung childrenAge-matched normal controlsAsymptomatic young childrenLeft ventricular dysfunctionSingle-center studyLV myocardial mechanicsTetralogy of FallotLV rotational mechanicsTwo-dimensional echocardiographyFurther longitudinal studiesLeft ventricular rotationRTOF childrenLack of maturationVentricular dysfunctionDiastolic dysfunctionDiastolic functionClinical outcomesValidation of Right Atrial Area as a Measure of Right Atrial Size and Normal Values of in Healthy Pediatric Population by Two-Dimensional Echocardiography
Rajagopal H, Uppu SC, Weigand J, Lee S, Karnik R, Ko H, Bhatla P, Nielsen J, Doucette J, Parness I, Srivastava S. Validation of Right Atrial Area as a Measure of Right Atrial Size and Normal Values of in Healthy Pediatric Population by Two-Dimensional Echocardiography. Pediatric Cardiology 2018, 39: 892-901. PMID: 29523923, DOI: 10.1007/s00246-018-1838-3.Peer-Reviewed Original ResearchConceptsRight atrial sizeTransthoracic echocardiographyTwo-dimensional echocardiographyRA areaRA sizeZ-scoreAtrial sizeEntire cohortRight atrial areaHealthy pediatric populationNormal reference valuesCardiovascular deathHeart failureAtrial areaPediatric populationPrognostic indicatorHealthy childrenRA volumeNormal valuesEchocardiographyInverse correlationRegression analysisReference standardCohortScores
2016
Pediatric Pulmonary Hypertension
Rajagopal H, Karnik R, Sahulee R. Pediatric Pulmonary Hypertension. Pediatrics In Review 2016, 37: 129-131. PMID: 26933230, DOI: 10.1542/pir.2015-0067.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2014
Cardiotoxicity and Cardioprotection in Childhood Cancer
Lipshultz SE, Sambatakos P, Maguire M, Karnik R, Ross SW, Franco VI, Miller TL. Cardiotoxicity and Cardioprotection in Childhood Cancer. Acta Haematologica 2014, 132: 391-399. PMID: 25228565, DOI: 10.1159/000360238.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAnthracycline cumulative doseAdverse late effectsSignificant cardiovascular diseaseUse of dexrazoxaneLong-term cardioprotectionAnthracycline chemotherapyCardiovascular damageCardioprotective strategiesOncological efficacyCardiac damageBlack raceCumulative doseFemale sexRisk factorsChildhood cancerCardiotoxic effectsCardiovascular diseaseLate effectsHigh riskHigh doseGenetic predispositionCardiotoxicityYounger ageTrisomy 21Nutritional supplementsIssues in solid-organ transplantation in children: translational research from bench to bedside
Lipshultz SE, Chandar JJ, Rusconi PG, Fornoni A, Abitbol CL, Burke GW, Zilleruelo GE, Pham SM, Perez EE, Karnik R, Hunter JA, Dauphin DD, Wilkinson JD. Issues in solid-organ transplantation in children: translational research from bench to bedside. Clinics 2014, 69: 55-72. PMID: 24860861, PMCID: PMC3884162, DOI: 10.6061/clinics/2014(sup01)11.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAntibody-mediated rejectionRenal transplantationCardiac transplantationGraft rejectionAcute antibody-mediated rejectionChronic antibody-mediated rejectionCardiac allograft vasculopathyPanel reactive antibodyPediatric renal transplantationPediatric cardiac transplantationCardiac graft rejectionSolid organ transplantationBiomarkers of inflammationCardiac transplant rejectionRole of biomarkersNew diagnostic approachAllograft vasculopathyHeart transplantationKidney transplantationEndomyocardial biopsyABO incompatibilityTransplant rejectionCardiomyocyte injuryAntibody assaysImmune functionAnthracycline-related cardiotoxicity in childhood cancer survivors
Lipshultz SE, Karnik R, Sambatakos P, Franco VI, Ross SW, Miller TL. Anthracycline-related cardiotoxicity in childhood cancer survivors. Current Opinion In Cardiology 2014, 29: 103-112. PMID: 24284979, DOI: 10.1097/hco.0000000000000034.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsAnthracycline-related cardiotoxicityCardiovascular complicationsAnthracycline treatmentRisk factorsCardioprotective agentGrowth hormone replacement therapyPrevention of cardiotoxicityHormone replacement therapySerious cardiovascular complicationsChildhood cancer survivorsLong-term outcomesUse of biomarkersDosage of anthracyclinesCardiac transplantationCardiac dysfunctionCancer survivorsCardiac injuryClinical manifestationsReplacement therapyEarly recognitionChildhood cancerCardiotoxic effectsΒ-blockersEnzyme inhibitorsCardiotoxicity