An amino acid as a cofactor for a catalytic polynucleotide
Roth A, Breaker R. An amino acid as a cofactor for a catalytic polynucleotide. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 6027-6031. PMID: 9600911, PMCID: PMC27579, DOI: 10.1073/pnas.95.11.6027.Peer-Reviewed Original ResearchConceptsAmino acidsRate enhancementDramatic rate enhancementMetal ion cofactorsAbsence of enzymeGeneral base catalystSuperior polymerChemical catalysisBiological catalystsRNA cleavage reactionCatalytic potentialOrganic cofactorImidazole groupsNatural ribozymesRNA worldBase catalystChemical groupsCatalytic mechanismCatalytic DNACleavage reactionIon cofactorProtein enzymesStructural foldingSubstrate cleavageConstituent amino acids