2005
Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance
Oppenheim DE, Roberts SJ, Clarke SL, Filler R, Lewis JM, Tigelaar RE, Girardi M, Hayday AC. Sustained localized expression of ligand for the activating NKG2D receptor impairs natural cytotoxicity in vivo and reduces tumor immunosurveillance. Nature Immunology 2005, 6: 928-937. PMID: 16116470, DOI: 10.1038/ni1239.Peer-Reviewed Original ResearchMeSH Keywords9,10-Dimethyl-1,2-benzanthraceneAnimalsCarcinomaCell Line, TumorDisease SusceptibilityDown-RegulationFemaleImmunologic SurveillanceKiller Cells, NaturalLigandsMaleMembrane ProteinsMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicNK Cell Lectin-Like Receptor Subfamily KPapillomaReceptors, ImmunologicReceptors, Natural Killer CellSkin NeoplasmsTetradecanoylphorbol AcetateT-LymphocytesTumor BurdenConceptsNKG2D downregulationNK cell-mediated cytotoxicityNatural killer cellsCell-mediated cytotoxicityInnate immune activationT cell defectsNKG2D engagementNatural cytotoxicityKiller cellsImmune activationReceptor NKG2DTumor immunosurveillanceCutaneous carcinogenesisTumor surveillanceT cellsReversible defectsRAE-1Normal epitheliumLigand expressionTumor resistanceCell defectsSustained expressionNKG2DImmunosurveillanceDownregulation
2003
The inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells
Pennington D, Silva-Santos B, Shires J, Theodoridis E, Pollitt C, Wise E, Tigelaar R, Owen M, Hayday A. The inter-relatedness and interdependence of mouse T cell receptor γδ+ and αβ+ cells. Nature Immunology 2003, 4: 991-998. PMID: 14502287, DOI: 10.1038/ni979.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell DifferentiationCyclic AMP Response Element ModulatorDNA-Binding ProteinsFlow CytometryGene Expression ProfilingGenes, T-Cell ReceptorH-Y AntigenMaleMiceMice, Inbred C57BLMice, KnockoutMice, TransgenicReceptors, Antigen, T-Cell, alpha-betaReceptors, Antigen, T-Cell, gamma-deltaRepressor ProteinsReverse Transcriptase Polymerase Chain ReactionRNA, MessengerT-LymphocytesConceptsΑβ T cellsConventional αβ T cellsCell developmentFunctional potentialGene profilesT cell receptorT cellsMouse T-cell receptorΓδ T cell developmentT cell developmentT cell progenitorsCell receptorGene expressionCell progenitorsCell populationsImmune responseTCR specificityCellsReceptorsPotential interdependenceProgenitorsExpression
2000
Development of Dendritic Epidermal T Cells with a Skewed Diversity of γδTCRs in Vδ1-Deficient Mice
Hara H, Kishihara K, Matsuzaki G, Takimoto H, Tsukiyama T, Tigelaar R, Nomoto K. Development of Dendritic Epidermal T Cells with a Skewed Diversity of γδTCRs in Vδ1-Deficient Mice. The Journal Of Immunology 2000, 165: 3695-3705. PMID: 11034374, DOI: 10.4049/jimmunol.165.7.3695.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, MonoclonalCell DifferentiationClone CellsCytokinesDendritic CellsEmbryonic and Fetal DevelopmentEpidermal CellsEpidermisFemaleFibroblast Growth Factor 10Fibroblast Growth Factor 7Fibroblast Growth FactorsGene DeletionGene Rearrangement, delta-Chain T-Cell Antigen ReceptorGenes, T-Cell Receptor deltaGenetic MarkersGrowth SubstancesImmunophenotypingMaleMiceMice, Inbred C57BLMice, KnockoutProtein ConformationReceptors, Antigen, T-Cell, gamma-deltaStem CellsT-LymphocytesThymus Gland
1999
Stevens-Johnson syndrome limited to multiple sites of radiation therapy in a patient receiving phenobarbital
Duncan K, Tigelaar R, Bolognia J. Stevens-Johnson syndrome limited to multiple sites of radiation therapy in a patient receiving phenobarbital. Journal Of The American Academy Of Dermatology 1999, 40: 493-496. PMID: 10071329, DOI: 10.1016/s0190-9622(99)70508-6.Peer-Reviewed Case Reports and Technical NotesConceptsStevens-Johnson syndromeRadiation therapyAtypical erythema multiformeSevere cutaneous eruptionsSite of radiationToxic epidermal necrolysisEpidermal necrolysisCutaneous eruptionErythema multiformeAdverse reactionsTherapySyndromePhenobarbitalMultiple sitesNecrolysisMedicationsSecond casePatientsPhenytoinMultiforme
1998
Conservation of T Cell Receptor Conformation in Epidermal γδ Cells with Disrupted Primary Vγ Gene Usage
Mallick-Wood C, Lewis J, Richie L, Owen M, Tigelaar R, Hayday A. Conservation of T Cell Receptor Conformation in Epidermal γδ Cells with Disrupted Primary Vγ Gene Usage. Science 1998, 279: 1729-1733. PMID: 9497293, DOI: 10.1126/science.279.5357.1729.Peer-Reviewed Original ResearchConceptsGene segmentsVariable region gene segmentsRegion gene segmentsParticular gene segmentsReceptor conformationTCR chainsReceptor gammaAssociation of expressionAlphabeta T cellsCellsConservationT-cell receptor gammaConformational determinantsGammadelta T cell subsetsGene usageT cellsConformationΓδ cellsB cellsLymphocyte repertoireVgamma5SitesDendritic epidermal T cellsExpressionRepertoire
1991
Adhesion Molecules CD11a, CD18, and ICAM-1 on Human Epidermal Langerhans Cells Serve a Functional Role in the Activation of Alloreactive T Cells
Simon J, Cruz P, Tigelaar R, Sontheimer R, Bergstresser P. Adhesion Molecules CD11a, CD18, and ICAM-1 on Human Epidermal Langerhans Cells Serve a Functional Role in the Activation of Alloreactive T Cells. Journal Of Investigative Dermatology 1991, 96: 148-151. PMID: 1670950, DOI: 10.1111/1523-1747.ep12515946.Peer-Reviewed Original ResearchConceptsPeripheral blood mononuclear leukocytesAdhesion molecules CD11aAlloreactive T cellsAntigen-presenting cellsLangerhans cellsT cellsICAM-1T cell activationAdhesion moleculesAccessory signalsAllogeneic peripheral blood mononuclear leukocytesHuman epidermal Langerhans cellsBlood mononuclear leukocytesEpidermal Langerhans cellsEpidermal cellsAdhesion molecule expressionTwo-color immunofluorescenceDependent T-cell activationRelevant adhesion moleculesEfficient T cell activationAllostimulatory capacityHuman epidermal cellsLC stimulationMolecule expressionMononuclear leukocytes
1988
Thy-1+ epidermal cells in nude mice are distinct from their counterparts in thymus-bearing mice. A study of morphology, function, and T cell receptor expression.
Nixon-Fulton J, Kuziel W, Santerse B, Bergstresser P, Tucker P, Tigelaar R. Thy-1+ epidermal cells in nude mice are distinct from their counterparts in thymus-bearing mice. A study of morphology, function, and T cell receptor expression. The Journal Of Immunology 1988, 141: 1897-903. PMID: 2902136, DOI: 10.4049/jimmunol.141.6.1897.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntigens, SurfaceBlotting, NorthernBlotting, SouthernCell DivisionConcanavalin ADendritic CellsEpidermal CellsEpidermisEthersFemaleInterleukin-2IonomycinMaleMiceMice, Inbred BALB CMice, Inbred CBAMice, NudeReceptors, Antigen, T-CellSpecies SpecificityTetradecanoylphorbol AcetateThy-1 AntigensThymus GlandConceptsIL-2Thy-1Nude miceNormal miceLow-dose IL-2BALB/c miceT cell receptor expressionModest proliferative responseThymus-bearing miceCell receptor expressionT cell differentiationTCR-gamma transcriptsC miceReceptor expressionAthymic miceProliferative responseNormal animalsTCR mRNACalcium ionophoreEpidermal cellsMiceNormal CBACon AFollicular epitheliumPopulation of cells
1986
Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells.
Sullivan S, Bergstresser P, Tigelaar R, Streilein J. Induction and regulation of contact hypersensitivity by resident, bone marrow-derived, dendritic epidermal cells: Langerhans cells and Thy-1+ epidermal cells. The Journal Of Immunology 1986, 137: 2460-7. PMID: 2876041, DOI: 10.4049/jimmunol.137.8.2460.Peer-Reviewed Original ResearchConceptsContact hypersensitivityBone marrow-derived populationLangerhans cellsThy-1Epicutaneous applicationInduction of CHSRegulation of CHSDendritic epidermal cellsRoute of immunizationEpidermal Langerhans cellsSpecific unresponsivenessAntigenic encounterCH responsesImmunogenic signalsSyngeneic miceImmunogenic capacityAntigenic signalIntact skinMouse skinCellular elementsEpidermal cellsHypersensitivityMiceCell typesInduction
1985
FACS Purification of Bone Marrow-Derived Epidermal Populations in Mice: Langerhans Cells and Thy-1+ Dendritic Cells
Sullivan S, Bergstresser P, Tigelaar R, Streilein J. FACS Purification of Bone Marrow-Derived Epidermal Populations in Mice: Langerhans Cells and Thy-1+ Dendritic Cells. Journal Of Investigative Dermatology 1985, 84: 491-495. PMID: 3998496, DOI: 10.1111/1523-1747.ep12273454.Peer-Reviewed Original ResearchConjugated avidin binds to mast cell granules.
Tharp M, Seelig L, Tigelaar R, Bergstresser P. Conjugated avidin binds to mast cell granules. Journal Of Histochemistry & Cytochemistry 1985, 33: 27-32. PMID: 2578142, DOI: 10.1177/33.1.2578142.Peer-Reviewed Original Research
1983
Contact hypersensitivity reactions to dinitrofluorobenzene mediated by monoclonal IgE anti-DNP antibodies.
Ray M, Tharp M, Sullivan T, Tigelaar R. Contact hypersensitivity reactions to dinitrofluorobenzene mediated by monoclonal IgE anti-DNP antibodies. The Journal Of Immunology 1983, 131: 1096-102. PMID: 6193174, DOI: 10.4049/jimmunol.131.3.1096.Peer-Reviewed Original ResearchConceptsContact hypersensitivity reactionHypersensitivity reactionsDNFB challengeUnsensitized controlsAntigen challengeReactive haptenMonoclonal IgE anti-DNP antibodyIgE anti-DNP antibodyIgE anti-hapten antibodyBALB/c miceAllergic contact dermatitis reactionsBiphasic patternIgE-sensitized miceEars of miceCutaneous hypersensitivity reactionsCutaneous hypersensitivity responseCutaneous inflammatory reactionsContact dermatitis reactionsFailure of miceAnti-hapten antibodiesAnti-DNP antibodiesEar challengeEar swellingHypersensitivity responseIgE antibodies
1976
Specific loss of stimulator activity following mixed lymphocyte reactions is due to cytotoxic cells
Janeway C, Mosier D, Tigelaar R. Specific loss of stimulator activity following mixed lymphocyte reactions is due to cytotoxic cells. European Journal Of Immunology 1976, 6: 747-750. PMID: 138373, DOI: 10.1002/eji.1830061017.Peer-Reviewed Original ResearchConceptsMixed lymphocyte reactionFresh spleen cellsSpleen cellsLymphocyte reactionOne-way mixed-lymphocyte reactionPrimary mixed lymphocyte reactionMouse strainsStimulator activityCytotoxic T cellsStrong mixed lymphocyte reactionsUnrelated mouse strainsCongenic mouse strainsCytotoxic cellsStimulator cellsT cellsRelease assaysSpecific lossCell activityResidual cellsB subregionRestricted expressionLymphocytesSuch cellsAntigenCells
1973
SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE
Tigelaar R, Asofsky R. SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE. Journal Of Experimental Medicine 1973, 137: 239-253. PMID: 4405532, PMCID: PMC2139477, DOI: 10.1084/jem.137.2.239.Peer-Reviewed Original ResearchConceptsThymus-derived cellsAdult syngeneic recipientsAnti-theta antibodyPeripheral lymph nodesNormal adult miceNormal lymphoid tissuesElicit graftGraft-VersusGVH reactionGVH reactivityLymph nodesRecipient spleensSpleen weightSyngeneic recipientsLymphoid tissueSpleen cellsLymphoid cellsAdult miceHost reactionHost responseNormal populationDistinct subpopulationsSubpopulationsFunctional heterogeneitySpleen
1972
KINETICS OF GRAFT-VERSUS-HOST SPLENOMEGALY IN NEONATAL F1 RECIPIENTS OF PARENTAL STRAIN MOUSE LYMPH NODE CELLS AND/OR THYMOCYTES
Tigelaar R, Asofsky R. KINETICS OF GRAFT-VERSUS-HOST SPLENOMEGALY IN NEONATAL F1 RECIPIENTS OF PARENTAL STRAIN MOUSE LYMPH NODE CELLS AND/OR THYMOCYTES. Transplantation 1972, 14: 805-807. PMID: 4404987, DOI: 10.1097/00007890-197212000-00025.Peer-Reviewed Original ResearchSYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE
Tigelaar R, Asofsky R. SYNERGY AMONG LYMPHOID CELLS MEDIATING THE GRAFT-VERSUS-HOST RESPONSE. Journal Of Experimental Medicine 1972, 135: 1059-1070. PMID: 4401814, PMCID: PMC2138974, DOI: 10.1084/jem.135.5.1059.Peer-Reviewed Original Research