2001
Induction of human tumor‐loaded dendritic cells
Berger C, Xu A, Hanlon D, Lee C, Schechner J, Glusac E, Christensen I, Snyder E, Holloway V, Tigelaar R, Edelson R. Induction of human tumor‐loaded dendritic cells. International Journal Of Cancer 2001, 91: 438-447. PMID: 11251964, DOI: 10.1002/1097-0215(200002)9999:9999<::aid-ijc1073>3.0.co;2-r.Peer-Reviewed Original ResearchMeSH KeywordsAntigens, CDApoptosisCD36 AntigensCell DifferentiationCell DivisionCell SurvivalCells, CulturedCytokinesCytoplasmDendritic CellsDose-Response Relationship, DrugFlow CytometryHumansImmunoglobulinsImmunohistochemistryImmunophenotypingImmunotherapyLeukapheresisLeukocytesLymphocytesMajor Histocompatibility ComplexMembrane GlycoproteinsMonocytesPhagocytosisPhenotypeTime FactorsT-LymphocytesConceptsExtracorporeal photopheresisDistinctive antigensTumor-loaded dendritic cellsStandard extracorporeal photopheresisMHC class II moleculesImproved cancer immunotherapyDendritic cell differentiationAnti-cancer vaccinesMalignant T cellsClass II moleculesTransition of monocytesDC vaccinesMalignant cell apoptosisDendritic cellsImmature DCsCancer immunotherapyCD83 expressionT cellsExogenous cytokinesSignificant proliferationCell apoptosisVaccineMembrane CD36Cell differentiationCells
1996
Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase.
Mallick-Wood C, Pao W, Cheng A, Lewis J, Kulkarni S, Bolen J, Rowley B, Tigelaar R, Pawson T, Hayday A. Disruption of epithelial gamma delta T cell repertoires by mutation of the Syk tyrosine kinase. Proceedings Of The National Academy Of Sciences Of The United States Of America 1996, 93: 9704-9709. PMID: 8790395, PMCID: PMC38493, DOI: 10.1073/pnas.93.18.9704.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsElectrophoresis, Polyacrylamide GelEnzyme PrecursorsEpithelial CellsEpitheliumFlow CytometryIntracellular Signaling Peptides and ProteinsLymphocytesMiceMutagenesis, Site-DirectedPolymerase Chain ReactionPolymorphism, Restriction Fragment LengthProtein-Tyrosine KinasesReceptors, Antigen, T-Cell, gamma-deltaSyk KinaseConceptsGamma delta T cellsDelta T cellsIntraepithelial gamma delta T cellsT cellsSplenic gamma delta T cellsSyk tyrosine kinaseGamma delta T cell repertoireGene rearrangementsT cell repertoireReceptor gene rearrangementsSyk-deficient miceDelta gene rearrangementsAntigen receptor gene rearrangementsTyrosine kinaseSyk deficiencyCell repertoireB cellsChimeric miceMiceSpecific epitheliaCellsLymphocytesSubstantial depletionCharacteristic associationsDevelopmental arrest
1985
Lymphocyte Traffic and the Skin
Tigelaar R. Lymphocyte Traffic and the Skin. Dermatologic Clinics 1985, 3: 569-585. PMID: 3916171, DOI: 10.1016/s0733-8635(18)30857-x.Peer-Reviewed Original ResearchConceptsPeripheral lymph nodesLymph nodesLymphocyte migrationEndothelial cellsLymphoid organsImmunologic influenceMesenteric lymph nodesMovement of lymphocytesLymphocyte membrane receptorsDifferent organ sitesSpecialized endothelial cellsNonlymphoid organsLymphocyte trafficImmunologic defenseT cellsGastrointestinal tractOrgan sitesBlast transformationMajor subsetSkinLymphocytesCommon determinantsOrgansMembrane receptorsCells
1976
Specific loss of stimulator activity following mixed lymphocyte reactions is due to cytotoxic cells
Janeway C, Mosier D, Tigelaar R. Specific loss of stimulator activity following mixed lymphocyte reactions is due to cytotoxic cells. European Journal Of Immunology 1976, 6: 747-750. PMID: 138373, DOI: 10.1002/eji.1830061017.Peer-Reviewed Original ResearchConceptsMixed lymphocyte reactionFresh spleen cellsSpleen cellsLymphocyte reactionOne-way mixed-lymphocyte reactionPrimary mixed lymphocyte reactionMouse strainsStimulator activityCytotoxic T cellsStrong mixed lymphocyte reactionsUnrelated mouse strainsCongenic mouse strainsCytotoxic cellsStimulator cellsT cellsRelease assaysSpecific lossCell activityResidual cellsB subregionRestricted expressionLymphocytesSuch cellsAntigenCells