2000
Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4
Herrick C, MacLeod H, Glusac E, Tigelaar R, Bottomly K. Th2 responses induced by epicutaneous or inhalational protein exposure are differentially dependent on IL-4. Journal Of Clinical Investigation 2000, 105: 765-775. PMID: 10727445, PMCID: PMC377464, DOI: 10.1172/jci8624.Peer-Reviewed Original ResearchConceptsTh2 responsesIL-13IL-4Th2-type immune responseIL-4-deficient miceTh2-promoting cytokinesOVA-specific IgG1Bronchoalveolar lavage fluidWild-type miceAllergen encounterTh2 sensitizationAirway challengeTh2 activationAllergen exposureAtopic individualsBAL fluidEnvironmental allergensWT miceLavage fluidPrimary exposureVivo depletionAnatomic sitesImmune responseAnimal modelsMice
1998
Intracutaneous vaccination of rabbits with the E6 gene of cottontail rabbit papillomavirus provides partial protection against virus challenge
Sundaram P, Tigelaar R, Xiao W, Brandsma J. Intracutaneous vaccination of rabbits with the E6 gene of cottontail rabbit papillomavirus provides partial protection against virus challenge. Vaccine 1998, 16: 613-623. PMID: 9569473, DOI: 10.1016/s0264-410x(97)84510-0.Peer-Reviewed Original ResearchConceptsCottontail rabbit papillomavirusHumoral immunityControl rabbitsIntracutaneous vaccinationChallenge sitePeripheral blood mononuclear cellsE6 genePartial protectionCRPV E6 proteinsRabbit papillomavirusBlood mononuclear cellsEffect of vaccinationPapillomavirus-induced diseaseE6 proteinMicrograms DNAPartial prophylaxisBooster vaccinationControl vaccineInitial vaccinationProphylactic immunityCellular immunityMononuclear cellsVirus challengeDNA vaccinationPapilloma burden