Robert Homer, MD, PhD

2025

• Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations

  McElderry J, Zhang T, Zhao W, Hoang P, Anyaso-Samuel S, Sang J, Khandekar A, Hartman C, Colón-Matos F, Miraftab M, Saha M, Lee O, Sharma S, Jones K, Zhu B, Díaz-Gay M, Mas L, Rodriguez O, Edell E, Santamaría J, Schabath M, Yendamuri S, Manczuk M, Lissowska J, Świątkowska B, Mukeria A, Shangina O, Zaridze D, Holcatova I, Janout V, Mates D, Ognjanovic S, Savic M, Kontic M, Bossé Y, Gould Rothberg B, Christiani D, Gaborieau V, Brennan P, Liu G, Hofman P, Wong M, Leung K, Chen C, Hsiung C, Rothman N, Leduc C, Baine M, Travis W, Sholl L, Joubert P, Homer R, Yang S, Lan Q, Nowak M, Wedge D, Alexandrov L, Chanock S, Vogtmann E, Abnet C, Shi J, Landi M. Microbiome analysis of 940 lung cancers in never-smokers reveals lack of clinically relevant associations. Nature Communications 2025 PMID: 41387456, DOI: 10.1038/s41467-025-66780-y.

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• Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma

  Zhang T, Zhao W, Wirth C, Díaz-Gay M, Yin J, Cecati M, Marchegiani F, Hoang P, Leduc C, Baine M, Travis W, Sholl L, Joubert P, Sang J, McElderry J, Antony M, Klein A, Khandekar A, Hartman C, Rosenbaum J, Colón-Matos F, Miraftab M, Saha M, Lee O, Jones K, Caporaso N, Wong M, Leung K, Hsiung C, Chen C, Edell E, Santamaría J, Schabath M, Yendamuri S, Manczuk M, Lissowska J, Świątkowska B, Mukeria A, Shangina O, Zaridze D, Holcatova I, Mates D, Milosavljevic S, Savic M, Bossé Y, Rothberg B, Christiani D, Gaborieau V, Brennan P, Liu G, Hofman P, Homer R, Yang S, Pesatori A, Consonni D, Yang L, Zhu B, Shi J, Brown K, Rothman N, Chanock S, Alexandrov L, Choi J, Cardelli M, Lan Q, Nowak M, Wedge D, Landi M. Uncovering the role of LINE-1 in the evolution of lung adenocarcinoma. Nature 2025, 1-12. PMID: 41372401, DOI: 10.1038/s41586-025-09825-y.

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• A prognostic signature for lung adenocarcinoma in patients who have never smoked.

  Zhao W, Zhang T, Hua X, Hoang P, Miraftab M, Saha M, McElderry J, Sang J, Lee O, Hartman C, Khandekar A, Sharma S, Colón-Matos F, Anyaso-Samuel S, Wang D, Jones K, Hutchinson A, Hicks B, Rosenbaum J, Zhong X, Yang Y, Pesatori A, Consonni D, Christiani D, Leung K, Wong M, Manczuk M, Lissowska J, Świątkowska B, Mukeria A, Shangina O, Zaridze D, Holcatova I, Mates D, Milosavljevic S, Ognjanovic S, Savic M, Kontic M, Gaborieau V, Brennan P, Arrieta O, Bossé Y, Edell E, Schabath M, Hofman P, Mas L, Yendamuri S, Chen C, Chang I, Hsiung C, Liu G, Martinez Santamaría J, Gould Rothberg B, Mutreja K, Lawrence S, Rothman N, Alexandrov L, Leduc C, Baine M, Joubert P, Sholl L, Travis W, Homer R, Lan Q, Chanock S, Yang L, Yang S, Shi J, Landi M. A prognostic signature for lung adenocarcinoma in patients who have never smoked. Cancer Discovery 2025 PMID: 41165571, DOI: 10.1158/2159-8290.cd-25-0581.

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• Intranasal hemagglutinin protein boosters induce protective mucosal immunity against influenza A viruses in mice

  Moriyama M, Rodrigues G, Wang J, Jayewickreme R, Hudak A, Dong H, Homer R, Ma S, Iwasaki A. Intranasal hemagglutinin protein boosters induce protective mucosal immunity against influenza A viruses in mice. Proceedings Of The National Academy Of Sciences Of The United States Of America 2025, 122: e2422171122. PMID: 40991437, PMCID: PMC12501169, DOI: 10.1073/pnas.2422171122.

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• The mutagenic forces shaping the genomes of lung cancer in never smokers

  Díaz-Gay M, Zhang T, Hoang P, Leduc C, Baine M, Travis W, Sholl L, Joubert P, Khandekar A, Zhao W, Steele C, Otlu B, Nandi S, Vangara R, Bergstrom E, Kazachkova M, Pich O, Swanton C, Hsiung C, Chang I, Wong M, Leung K, Sang J, McElderry J, Hartman C, Colón-Matos F, Miraftab M, Saha M, Lee O, Jones K, Gallego-García P, Yang Y, Zhong X, Edell E, Santamaría J, Schabath M, Yendamuri S, Manczuk M, Lissowska J, Świątkowska B, Mukeria A, Shangina O, Zaridze D, Holcatova I, Mates D, Milosavljevic S, Kontic M, Bossé Y, Rothberg B, Christiani D, Gaborieau V, Brennan P, Liu G, Hofman P, Yang L, Nowak M, Shi J, Rothman N, Wedge D, Homer R, Yang S, Pesatori A, Consonni D, Lan Q, Zhu B, Chanock S, Choi J, Alexandrov L, Landi M. The mutagenic forces shaping the genomes of lung cancer in never smokers. Nature 2025, 644: 133-144. PMID: 40604281, PMCID: PMC12667038, DOI: 10.1038/s41586-025-09219-0.

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• Prediction of Lymph Node Metastasis in Non–Small Cell Lung Carcinoma Using Primary Tumor Somatic Mutation Data

  Lee V, Moore N, Doyle J, Hicks D, Oh P, Bodofsky S, Hossain S, Patel A, Aneja S, Homer R, Park H. Prediction of Lymph Node Metastasis in Non–Small Cell Lung Carcinoma Using Primary Tumor Somatic Mutation Data. JCO Clinical Cancer Informatics 2025, 9: e2400303. PMID: 40446175, DOI: 10.1200/cci-24-00303.

  Peer-Reviewed Original Research

  This study investigates machine learning models using tumor genetic data to predict lymph node metastasis in lung cancer, showing improved accuracy over traditional methods and more potential for personalized treatment.

  Full Summary

• APOBEC affects tumor evolution and age at onset of lung cancer in smokers

  Zhang T, Sang J, Hoang P, Zhao W, Rosenbaum J, Johnson K, Klimczak L, McElderry J, Klein A, Wirth C, Bergstrom E, Díaz-Gay M, Vangara R, Colon-Matos F, Hutchinson A, Lawrence S, Cole N, Zhu B, Przytycka T, Shi J, Caporaso N, Homer R, Pesatori A, Consonni D, Imielinski M, Chanock S, Wedge D, Gordenin D, Alexandrov L, Harris R, Landi M. APOBEC affects tumor evolution and age at onset of lung cancer in smokers. Nature Communications 2025, 16: 4711. PMID: 40394004, PMCID: PMC12092836, DOI: 10.1038/s41467-025-59923-8.

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• Secretory leukocyte protease inhibitor influences periarticular joint inflammation in Borrelia burgdorferi-infected mice

  Yu Q, Tang X, Hart T, Homer R, Belperron A, Bockenstedt L, Ring A, Nakamura A, Fikrig E. Secretory leukocyte protease inhibitor influences periarticular joint inflammation in Borrelia burgdorferi-infected mice. ELife 2025, 14: rp104913. PMID: 40392222, PMCID: PMC12092001, DOI: 10.7554/elife.104913.

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• Secretory leukocyte protease inhibitor influences periarticular joint inflammation in Borrelia burgdorferi-infected mice

  Yu Q, Tang X, Hart T, Homer R, Belperron A, Bockenstedt L, Ring A, Nakamura A, Fikrig E. Secretory leukocyte protease inhibitor influences periarticular joint inflammation in Borrelia burgdorferi-infected mice. ELife 2025, 14 DOI: 10.7554/elife.104913.4.

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• Applying Single-Cell Spatial Profiling to Assess Niches in Human Fibrotic Silica Lung

  Abu Hussein N, Adams T, Anderson S, Kramer M, Nekola F, Homer R, Najjar A, Sharma P, Rangel R, Yang L, Zhang Y, Yan X, Pertzov B, Kaminski N. Applying Single-Cell Spatial Profiling to Assess Niches in Human Fibrotic Silica Lung. American Journal Of Respiratory And Critical Care Medicine 2025, 211: a5093-a5093. DOI: 10.1164/ajrccm.2025.211.abstracts.a5093.

  Peer-Reviewed Original Research