2020
Impact of intra-tumoral heterogeneity detected by next-generation sequencing on acute myeloid leukemia survival
Schulz WL, Rinder HM, Durant TJS, Tormey CA, Torres R, Smith BR, Hager KM, Howe JG, Siddon AJ. Impact of intra-tumoral heterogeneity detected by next-generation sequencing on acute myeloid leukemia survival. Leukemia & Lymphoma 2020, 61: 3269-3271. PMID: 32715805, DOI: 10.1080/10428194.2020.1797016.Peer-Reviewed Original Research
2016
Evaluation of relational and NoSQL database architectures to manage genomic annotations
Schulz WL, Nelson BG, Felker DK, Durant TJ, Torres R. Evaluation of relational and NoSQL database architectures to manage genomic annotations. Journal Of Biomedical Informatics 2016, 64: 288-295. PMID: 27810480, DOI: 10.1016/j.jbi.2016.10.015.Peer-Reviewed Original ResearchMeSH KeywordsDatabase Management SystemsDatabases, GeneticGenomicsHigh-Throughput Nucleotide SequencingHumansInformation Storage and RetrievalConceptsRelational databaseNoSQL databasesQuery efficiencyData managementData storageDocument-oriented NoSQL databaseBiomedical data setsCommon relational databaseQuery retrievalDatabase technologyInformatics infrastructureRelational modelGenomic annotationsIndexingData setsArchitectureRetrievalAnnotationNew technologiesDatabaseTechnologySignificant advantagesRelative advantagesInfrastructureStorage
2015
Computational Approach to Annotating Variants of Unknown Significance in Clinical Next Generation Sequencing
Schulz WL, Tormey CA, Torres R. Computational Approach to Annotating Variants of Unknown Significance in Clinical Next Generation Sequencing. Lab Medicine 2015, 46: 285-289. PMID: 26489672, DOI: 10.1309/lmwzh57brwopr5rq.Peer-Reviewed Original ResearchMeSH KeywordsAlgorithmsComputational BiologyHigh-Throughput Nucleotide SequencingHumansMolecular Sequence AnnotationSequence Analysis, DNAConceptsNext-generation sequencingClinical significanceUnknown clinical significanceMalignant neoplasmsHematologic malignanciesClinical next-generation sequencingSoftware algorithmsGeneration sequencingUnknown significanceBenign variantsConflicting resultsClinical laboratoriesComputational toolsCommon technologyAlgorithm