2010
Significant Sirolimus and Dronedarone Interaction in a Kidney Transplant Recipient
Tichy EM, Medwid AJ, Mills EA, Formica RN, Kulkarni S. Significant Sirolimus and Dronedarone Interaction in a Kidney Transplant Recipient. Annals Of Pharmacotherapy 2010, 44: 1338-1341. PMID: 20484171, DOI: 10.1345/aph.1p114.Peer-Reviewed Original ResearchConceptsSignificant pharmacokinetic interactionsTrough concentrationsPharmacokinetic interactionsHorn Drug Interaction Probability ScaleNarrow therapeutic index medicationsDrug Interaction Probability ScaleKidney transplant recipientsPost-kidney transplantDronedarone initiationExcessive immunosuppressionImmunosuppressive regimenIndex medicationSirolimus toxicityTransplant recipientsMycophenolate mofetilStable doseConcurrent administrationAtrial fibrillationSirolimus concentrationsBloody diarrheaTherapeutic misadventureDose reductionClose monitoringDronedaroneSirolimus
2002
Evolving role of sirolimus immunosuppression after organ transplantation
Formica R, Friedman A, Lorber M. Evolving role of sirolimus immunosuppression after organ transplantation. Current Opinion In Organ Transplantation 2002, 7: 353-358. DOI: 10.1097/00075200-200212000-00009.Peer-Reviewed Original ResearchCalcineurin inhibitorsOrgan transplantationG1-S phase cell cycle arrestHigher serum creatinine valuesBiologic side effectsSirolimus-treated patientsCalcineurin inhibitor tacrolimusSerum creatinine valuesPivotal clinical trialsReduced rejection ratesPhase cell cycle arrestAllograft arteriosclerosisSirolimus immunosuppressionTriglyceride elevationLymphocele formationSirolimus useReversible thrombocytopeniaSerum cholesterolCreatinine valuesCell cycle arrestClinical trialsSide effectsSirolimusComplex woundsFull dose