2023
Targeting regulated chondrocyte death in osteoarthritis therapy
Zhu R, Wang Y, Ouyang Z, Hao W, Zhou F, Lin Y, Cheng Y, Zhou R, Hu W. Targeting regulated chondrocyte death in osteoarthritis therapy. Biochemical Pharmacology 2023, 215: 115707. PMID: 37506921, DOI: 10.1016/j.bcp.2023.115707.Peer-Reviewed Original ResearchConceptsChondrocyte deathCartilage degenerationArticular cartilage degenerationBone erosionExtracellular matrix degradationOA preventionOA pathogenesisChondrocyte senescenceCartilage lossOsteoarthritis therapyOA treatmentOsteoarthritisCell death modeDeathMatrix degradationEssential hallmarkTreatment methodsDegenerationForm of deathDeath modeTreatmentPathogenesisTherapyProgressionPreventionCartilage-Related Collagens in Osteoarthritis and Rheumatoid Arthritis: From Pathogenesis to Therapeutics
Ouyang Z, Dong L, Yao F, Wang K, Chen Y, Li S, Zhou R, Zhao Y, Hu W. Cartilage-Related Collagens in Osteoarthritis and Rheumatoid Arthritis: From Pathogenesis to Therapeutics. International Journal Of Molecular Sciences 2023, 24: 9841. PMID: 37372989, PMCID: PMC10298547, DOI: 10.3390/ijms24129841.Peer-Reviewed Original ResearchMeSH KeywordsArthritis, RheumatoidCartilage, ArticularCollagenExtracellular MatrixHumansOsteoarthritisConceptsRheumatoid arthritisArticular cartilageCourse of osteoarthritisNew biochemical markersDisease progressionPathogenic factorsCartilage damageDegradation of collagenBiochemical markersProgressive destructionClinical diagnosisMechanical injuryConnective tissueDisease statesRole of collagenCollagen productionLow immunogenicityFacilitate drug developmentArthritisDrug developmentOsteoarthritisBiomechanical propertiesMechanical functionCartilageCollagen
2022
Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation
Ding J, Chen Y, Zhao Y, Chen F, Dong L, Zhang H, Hu W, Li S, Zhou R, Hu W. Acid-sensitive ion channel 1a mediates osteoarthritis chondrocyte senescence by promoting Lamin B1 degradation. Biochemical Pharmacology 2022, 202: 115107. PMID: 35643339, DOI: 10.1016/j.bcp.2022.115107.Peer-Reviewed Original ResearchConceptsAcid-sensitive ion channel 1aChondrocyte senescenceIon channel 1aChannel 1aBeclin-1Chronic joint diseaseBeclin-1 protein expressionRat OA modelProtein Beclin 1Senescence-related markersJoint diseaseOA modelAging of chondrocytesJoint cavityPsalmotoxin-1Chondrocyte autophagyOsteoarthritisB1 expressionProtein expressionCationic channelsHairpin RNALamin B1Autophagy pathwayArticular cartilageLamin B1 expression
2021
Curcumin ameliorates IL‐1β‐induced apoptosis by activating autophagy and inhibiting the NF‐κB signaling pathway in rat primary articular chondrocytes
Chen T, Zhou R, Chen Y, Fu W, Wei X, Ma G, Hu W, Lu C. Curcumin ameliorates IL‐1β‐induced apoptosis by activating autophagy and inhibiting the NF‐κB signaling pathway in rat primary articular chondrocytes. Cell Biology International 2021, 45: 976-988. PMID: 33377585, DOI: 10.1002/cbin.11541.Peer-Reviewed Original ResearchConceptsIL-1βChondrocyte apoptosisProtective effectNF-κBPrimary articular chondrocytesNF-κB inhibitor pyrrolidine dithiocarbamatePhosphorylation levelsArticular chondrocytesCurcumin-mediated protectionWnt/β-catenin inhibitorInhibitor pyrrolidine dithiocarbamateIL-1β stimulationArticular chondrocyte apoptosisArticular cartilage damageΒ-catenin inhibitorMechanism of curcuminArticular cartilage diseaseSynthase kinase-3βCurcumin pretreatmentRheumatoid arthritisΚB p65Chondrocyte injuryInterleukin-1βCartilage damageXAV-939