2021
Systemic pharmacological verification of Baixianfeng decoction regulating TNF-PI3K-Akt-NF-κB pathway in treating rheumatoid arthritis
Wei X, Zhou R, Chen Y, Ma G, Yang Y, Lu C, Xu W, Hu W. Systemic pharmacological verification of Baixianfeng decoction regulating TNF-PI3K-Akt-NF-κB pathway in treating rheumatoid arthritis. Bioorganic Chemistry 2021, 119: 105519. PMID: 34864624, DOI: 10.1016/j.bioorg.2021.105519.Peer-Reviewed Original ResearchConceptsAdjuvant arthritis ratsRheumatoid arthritisArthritis ratsIL-1βIL-6Akt-NFSystemic pharmacologyAdjuvant arthritis rat modelAnimal experimentsPathological phenotypesProtein expressionArthritis rat modelP-p65 proteinP-PI3KPathway protein expressionTraditional Chinese medicinePharmacological verificationInflammatory factorsSystemic diseaseRat modelΚB pathwayDegradation of collagenP-AktTNFSerum contentSystemic pharmacological investigation of the Feng Shi Gu Tong capsule in the treatment of rheumatoid arthritis
Wei X, Fu W, Zhou R, Chen Y, Lu C, Hu W. Systemic pharmacological investigation of the Feng Shi Gu Tong capsule in the treatment of rheumatoid arthritis. Naunyn-Schmiedeberg's Archives Of Pharmacology 2021, 394: 1285-1299. PMID: 33527195, DOI: 10.1007/s00210-021-02048-8.Peer-Reviewed Original ResearchMeSH KeywordsAntirheumatic AgentsArthritis, RheumatoidCaco-2 CellsDrugs, Chinese HerbalHumansMedicine, Chinese TraditionalNetwork PharmacologyProtein Interaction MapsSignal TransductionConceptsRheumatoid arthritisTreatment of RAActive rheumatoid arthritisDisease target networkChinese traditional patent medicineTraditional Chinese medicineRA diseaseMolecular mechanismsImmune responsePharmacological effectsPrecise molecular mechanismsClinical practiceSystemic pharmacologyPharmacological investigationsElimination parametersChinese medicinePatent medicinePotential mechanismsDirect targetArthritisTreatmentCandidate compoundsTotalCapsuleProtein-protein interaction network
2020
Network pharmacology-based study on the mechanism of Yiganling capsule in hepatitis B treatment
Lu C, Fu W, Zhou R, Hu W. Network pharmacology-based study on the mechanism of Yiganling capsule in hepatitis B treatment. BMC Complementary Medicine And Therapies 2020, 20: 37. PMID: 32024508, PMCID: PMC7076828, DOI: 10.1186/s12906-020-2815-y.Peer-Reviewed Original ResearchMeSH KeywordsCapsulesDrugs, Chinese HerbalHepatitis BHumansMedicine, Chinese TraditionalProtein Interaction MapsConceptsHepatitis BCompound-target networkNetwork pharmacology-based studyTraditional Chinese medicinal compoundHepatitis B treatmentFavorable treatment effectChinese medicinal compoundsDisease target networkTraditional Chinese medicine preparationChinese medicine preparationEnrichment analysisPharmacological mechanismsMedicine DatabaseConclusionThis studyChinese Medicine DatabaseProtein-protein interaction networkDisease targetsDisease databaseMedicine preparationTreatment effectsActive compoundsB treatmentHB treatmentTreatmentCapsule