2022
Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases
Zhou R, Liang H, Hu W, Ding J, Li S, Chen Y, Zhao Y, Lu C, Chen F, Hu W. Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases. Ageing Research Reviews 2022, 83: 101785. PMID: 36371015, DOI: 10.1016/j.arr.2022.101785.Peer-Reviewed Original ResearchConceptsAcid-sensing ion channel 1aAge-related diseasesTherapeutic targetPotential therapeutic targetMost age-related diseasesIon channel 1aNovel drug targetsEffective drugsMultiple organsPathophysiological processesChannel 1aDiseaseChannel family membersPharmacological propertiesImproved treatmentSuch diseasesTissue degenerationCellular apoptosisTreatmentDrug targetsFamily membersPhysiological functionsUrgent needWorldwide populationIschemia
2019
β-Estradiol Protects Against Acidosis-Mediated and Ischemic Neuronal Injury by Promoting ASIC1a (Acid-Sensing Ion Channel 1a) Protein Degradation
Zhou R, Leng T, Yang T, Chen F, Hu W, Xiong Z. β-Estradiol Protects Against Acidosis-Mediated and Ischemic Neuronal Injury by Promoting ASIC1a (Acid-Sensing Ion Channel 1a) Protein Degradation. Stroke 2019, 50: 2902-2911. PMID: 31412757, PMCID: PMC6756944, DOI: 10.1161/strokeaha.119.025940.Peer-Reviewed Original ResearchConceptsIschemic neuronal injuryIschemic brain injuryΒ-estradiol treatmentASIC1a protein expressionNeuronal injuryASIC currentsBrain injuryProtein expressionΒ-estradiolWhole-cell patch-clamp techniqueIntracellular CaAcidosis-induced cytotoxicityAcidosis-mediated injuryActivation of ASIC1aDegree of neuroprotectionOutcome of strokeSeverity of strokeMiddle cerebral arteryTransient focal ischemiaOnline visual overviewAcid-induced elevationEstrogen receptor αReal-time polymerase chain reactionQuantitative real-time polymerase chain reactionPatch-clamp technique