2021
Systemic pharmacological verification of Baixianfeng decoction regulating TNF-PI3K-Akt-NF-κB pathway in treating rheumatoid arthritis
Wei X, Zhou R, Chen Y, Ma G, Yang Y, Lu C, Xu W, Hu W. Systemic pharmacological verification of Baixianfeng decoction regulating TNF-PI3K-Akt-NF-κB pathway in treating rheumatoid arthritis. Bioorganic Chemistry 2021, 119: 105519. PMID: 34864624, DOI: 10.1016/j.bioorg.2021.105519.Peer-Reviewed Original ResearchConceptsAdjuvant arthritis ratsRheumatoid arthritisArthritis ratsIL-1βIL-6Akt-NFSystemic pharmacologyAdjuvant arthritis rat modelAnimal experimentsPathological phenotypesProtein expressionArthritis rat modelP-p65 proteinP-PI3KPathway protein expressionTraditional Chinese medicinePharmacological verificationInflammatory factorsSystemic diseaseRat modelΚB pathwayDegradation of collagenP-AktTNFSerum content
2019
ROS play an important role in ATPR inducing differentiation and inhibiting proliferation of leukemia cells by regulating the PTEN/PI3K/AKT signaling pathway
Feng Y, Hua X, Niu R, Du Y, Shi C, Zhou R, Chen F. ROS play an important role in ATPR inducing differentiation and inhibiting proliferation of leukemia cells by regulating the PTEN/PI3K/AKT signaling pathway. Biological Research 2019, 52: 26. PMID: 31053167, PMCID: PMC6498685, DOI: 10.1186/s40659-019-0232-9.Peer-Reviewed Original ResearchConceptsPI3K/Akt pathwayPTEN/PI3K/AKT pathwayPTEN/PI3K/AKTPI3K/AktReactive oxygen speciesTrans retinoic acid (ATRA) derivativeAnti-AML effectAkt pathwayTreatment of AMLBackgroundAcute myeloid leukemiaCell proliferationAnti-tumor characteristicsIncurable hematological malignancyRetinoic acid derivativesG0/G1 phaseCCK-8 assayCell cycle distributionCell differentiationDifferentiation-related proteinFrequent relapsesStandard chemotherapyClinical outcomesCell line NB4Myeloid leukemiaNovel therapies