2023
Core Constituents of Caragana sinica Root for Rheumatoid Arthritis Treatment and the Potential Mechanism
Qu B, Wang S, Zhu H, Yin T, Zhou R, Hu W, Lu C. Core Constituents of Caragana sinica Root for Rheumatoid Arthritis Treatment and the Potential Mechanism. ACS Omega 2023, 8: 2586-2595. PMID: 36687056, PMCID: PMC9851025, DOI: 10.1021/acsomega.2c07094.Peer-Reviewed Original ResearchRheumatoid arthritis treatmentAnti-inflammatory effectsRA treatmentEthyl acetate extractArthritis treatmentHerbal constituentsPotential mechanismsNuclear factor kappa B (NF-κB) signal pathwayGood anti-inflammatory effectAnti-arthritis effectsUltra-performance liquid chromatographyNF-κB p65Herb productsB signal pathwayNF-κB pathwayArthritis ratsBioinformatics analysisBetter efficacyTherapeutic efficacyPharmacological roleOral bioavailabilityDrug-like propertiesFolk medicineSignal pathwayTreatment
2018
Necrostatin-1 ameliorates adjuvant arthritis rat articular chondrocyte injury via inhibiting ASIC1a-mediated necroptosis
Chen Y, Zhu C, Zhu F, Dai B, Song S, Wang Z, Feng Y, Ge J, Zhou R, Chen F. Necrostatin-1 ameliorates adjuvant arthritis rat articular chondrocyte injury via inhibiting ASIC1a-mediated necroptosis. Biochemical And Biophysical Research Communications 2018, 504: 843-850. PMID: 30219231, DOI: 10.1016/j.bbrc.2018.09.031.Peer-Reviewed Original ResearchConceptsRat articular cartilageRheumatoid arthritisNec-1Necrostatin-1Potential therapeutic strategyAcid-induced increaseChannel inhibitor amilorideArticular cartilage damageReceptor interacting protein 1Articular cartilageRIP1/RIP3Chondrocyte injuryAA ratsCartilage damageTherapeutic strategiesRA treatmentCartilage injuryPathophysiological processesPsalmotoxin-1Inhibitor necrostatin-1Expression of RIP1Inhibitor amilorideRIP1 inhibitor necrostatin-1Interacting protein 1ASIC1a