2022
Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases
Zhou R, Liang H, Hu W, Ding J, Li S, Chen Y, Zhao Y, Lu C, Chen F, Hu W. Modulators of ASIC1a and its potential as a therapeutic target for age-related diseases. Ageing Research Reviews 2022, 83: 101785. PMID: 36371015, DOI: 10.1016/j.arr.2022.101785.Peer-Reviewed Original ResearchConceptsAcid-sensing ion channel 1aAge-related diseasesTherapeutic targetPotential therapeutic targetMost age-related diseasesIon channel 1aNovel drug targetsEffective drugsMultiple organsPathophysiological processesChannel 1aDiseaseChannel family membersPharmacological propertiesImproved treatmentSuch diseasesTissue degenerationCellular apoptosisTreatmentDrug targetsFamily membersPhysiological functionsUrgent needWorldwide populationIschemiaRegulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis
Lin Y, Zhao Y, Zhang H, Hao W, Zhu R, Wang Y, Hu W, Zhou R. Regulatory role of KCa3.1 in immune cell function and its emerging association with rheumatoid arthritis. Frontiers In Immunology 2022, 13: 997621. PMID: 36275686, PMCID: PMC9580404, DOI: 10.3389/fimmu.2022.997621.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisSynovial inflammationImmune cellsCollagen antibody-induced arthritis modelAntibody-induced arthritis modelCartilage/bone destructionPathogenesis of RACommon autoimmune diseaseImmune cell functionPotential therapeutic targetIntermediate-conductance CaImmune balanceRA patientsBone destructionImmune dysfunctionChronic inflammationArthritis modelAutoimmune diseasesPeripheral bloodArticular synoviumPathological progressionCartilage damageKCa3.1 channelsTherapeutic targetAbnormal activation
2021
Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases
Liang H, Chen Y, Wei X, Ma G, Ding J, Lu C, Zhou R, Hu W. Immunomodulatory functions of TRPM7 and its implications in autoimmune diseases. Immunology 2021, 165: 3-21. PMID: 34558663, DOI: 10.1111/imm.13420.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAutoimmune DiseasesAutoimmunityBiomarkersDisease SusceptibilityDrug DevelopmentGene Expression RegulationHumansImmune SystemImmunomodulationIon Channel GatingOrgan SpecificityProtein Kinase InhibitorsProtein Serine-Threonine KinasesSignal TransductionStructure-Activity RelationshipTRPM Cation ChannelsConceptsAutoimmune diseasesRole of TRPM7New treatment targetsPotential therapeutic targetReceptor ion channelsImmune toleranceRheumatoid arthritisMultiple sclerosisSystemic disordersBody of evidenceImmune cellsCytokine secretionImmunoreactive substancesFunctional damageImmunomodulatory functionsTherapeutic targetTreatment targetsDiseaseEffective interventionsPharmacological propertiesOne-tissueTRPM7Physiologic conditionsInappropriate responsesCell migration