2023
Core Constituents of Caragana sinica Root for Rheumatoid Arthritis Treatment and the Potential Mechanism
Qu B, Wang S, Zhu H, Yin T, Zhou R, Hu W, Lu C. Core Constituents of Caragana sinica Root for Rheumatoid Arthritis Treatment and the Potential Mechanism. ACS Omega 2023, 8: 2586-2595. PMID: 36687056, PMCID: PMC9851025, DOI: 10.1021/acsomega.2c07094.Peer-Reviewed Original ResearchRheumatoid arthritis treatmentAnti-inflammatory effectsRA treatmentEthyl acetate extractArthritis treatmentHerbal constituentsPotential mechanismsNuclear factor kappa B (NF-κB) signal pathwayGood anti-inflammatory effectAnti-arthritis effectsUltra-performance liquid chromatographyNF-κB p65Herb productsB signal pathwayNF-κB pathwayArthritis ratsBioinformatics analysisBetter efficacyTherapeutic efficacyPharmacological roleOral bioavailabilityDrug-like propertiesFolk medicineSignal pathwayTreatment
2021
Systemic pharmacological investigation of the Feng Shi Gu Tong capsule in the treatment of rheumatoid arthritis
Wei X, Fu W, Zhou R, Chen Y, Lu C, Hu W. Systemic pharmacological investigation of the Feng Shi Gu Tong capsule in the treatment of rheumatoid arthritis. Naunyn-Schmiedeberg's Archives Of Pharmacology 2021, 394: 1285-1299. PMID: 33527195, DOI: 10.1007/s00210-021-02048-8.Peer-Reviewed Original ResearchConceptsRheumatoid arthritisTreatment of RAActive rheumatoid arthritisDisease target networkChinese traditional patent medicineTraditional Chinese medicineRA diseaseMolecular mechanismsImmune responsePharmacological effectsPrecise molecular mechanismsClinical practiceSystemic pharmacologyPharmacological investigationsElimination parametersChinese medicinePatent medicinePotential mechanismsDirect targetArthritisTreatmentCandidate compoundsTotalCapsuleProtein-protein interaction network