ASIC1a-CMPK2-mediated M1 macrophage polarization exacerbates chondrocyte senescence in osteoarthritis through IL-18
Dong L, Zhao Y, Sun C, Ou Yang Z, Chen F, Hu W, Zhang H, Wang Y, Zhu R, Cheng Y, Chen Y, Li S, Wang K, Ding C, Zhou R, Hu W. ASIC1a-CMPK2-mediated M1 macrophage polarization exacerbates chondrocyte senescence in osteoarthritis through IL-18. International Immunopharmacology 2023, 124: 110878. PMID: 37660594, DOI: 10.1016/j.intimp.2023.110878.Peer-Reviewed Original ResearchAcid-sensing ion channel 1aM1 macrophage polarizationM1 macrophagesChondrocyte senescenceMacrophage polarizationIL-18OA patientsPcTX-1IL-18 stimulationOA cartilage damageArticular cartilage destructionMouse OA modelIntra-articular administrationPromising treatment targetIon channel 1aMacrophage-associated genesMacrophage-mediated diseasesMechanism of actionASIC1a expressionOA miceCartilage destructionM1 polarizationCartilage damageOA modelSynovial fluid